Josh Allen faces Zach Wilson as the New York Jets confront a major test of their defense against the soaraway Buffalo Bills, while the Los Angeles Rams will look to keep up their remarkable record against the Tampa Bay Buccaneers.
Could Derrick Henry have another monumental game in him after last week's big effort, and after he dispelled worries about a foot problem?
Stats Perform has taken a look at the numbers ahead of Sunday's games, beginning with the travails of the Brady bunch.
Los Angeles Rams (3-4) at Tampa Bay Buccaneers (3-5)
The Buccaneers are on the slide, and the Rams are just about the nightmare opponents this weekend, judging by recent games between the teams.
Including Los Angeles' win in last season's Divisional Round, the Rams are 9-1 in their last 10 games against the Bucs, and that includes a 5-0 streak in Tampa.
This game is big for both, and for the Bucs it offers a chance to halt a losing sequence of three. They were beaten 27-22 by the Baltimore last week and are on their longest single-season losing run since a dismal four-game run in the 2019 season.
It remains to be seen whether Tom Brady can get them out of this mess. Brady threw for 325 yards and zero interceptions in last week's loss to Baltimore. Across his stellar career, he is 54-7 when throwing 300 yards and no interceptions, but this season he is 1-2 in such games.
Brady might fancy the job against a Rams team who have scored 14 or fewer points and lost by double-digits four times already this season, including last time out in a 31-14 home loss to the San Francisco 49ers.
Rival quarterback Matthew Stafford threw for 187 yards last week on 33 attempts. His team are 2-9 in games where Stafford has thrown the ball at least 30 times and finished with fewer than 200 passing yards.
Buffalo Bills (6-1) at New York Jets (5-3)
The Buffalo Bills are 6-1 for the first time since 1993, the season they last made it through to the Super Bowl. This weekend they go after a fifth win in a row after getting the better of the Green Bay Packers last time out.
What's more, they have strung together a four-game winning streak in road games against the Jets, second only in franchise history to a seven-game streak from 1987 to 1993.
The Bills have outscored this season's opponents by 105 points (203-98) so far, the widest differential in the NFL.
Bills quarterback Josh Allen has urged the Jets to show patience with his struggling counterpart Zach Wilson, who has completed just 54.9 per cent of passes this season, the second-worst rate in the NFL heading into Week 9. Wilson has thrown for 1,048 yards across five games, with three touchdowns and five interceptions, compared to Allen's 2,198 yards for 19 TDs and six interceptions from seven games.
Stefon Diggs has at least 100 yards and a receiving touchdown in three straight games, the longest streak of the Bills wide receiver's career and tied for the longest streak in team history with Elbert Dubenion (1964). The last NFL player with a longer streak was Adam Thielen in 2018 (five). How Diggs fares against Jets rookie cornerback Sauce Gardner will be a factor.
The Jets have already topped last season's four wins, but they are 8-30 against divisional opponents since 2016, the worst record in the NFL.
Tennessee Titans (5-2) at Kansas City Chiefs (5-2)
What does Titans running back Henry have in store for an encore? Henry last week recorded his sixth career 200-yard rushing game, with 219 yards and two touchdowns against the Texans, tying Adrian Peterson and O.J. Simpson for the most all-time. All other active players have combined for just four such games.
The Chiefs will be wary of that threat, and will look to their own WR, JuJu Smith-Schuster, to make his own impact. After failing to reach 90 yards or find the endzone in his first five games this season, Smith-Schuster now has back-to-back games with at least 100 yards and a touchdown. He had not had such a game since Week 8, 2019 and now has eight such games in his career.
The Titans have won four straight regular season matchups with the Chiefs but lost in the 2020 AFC Championship Game in Kansas City.
Their respective 5-2 records this season disguise the fact each of those wins has been relatively close. The Titans and Vikings have only won by single digits this season. Only five teams in NFL history have seen such a streak reach six games – the 2020 Chiefs, 1997 Vikings, 1994 Giants, 1988 Saints and 1986 Giants. Of those, only the Chiefs' streak reached seven.
Elsewhere...
The Miami Dolphins (5-3) will be looking for a fourth consecutive road win against the Chicago Bears (3-5), which would make the Dolphins the first AFC team since the conference came into being in 1970 to have such a streak in Chicago. Miami's Tyreek Hill has gone 52 consecutive receptions without a receiving touchdown. That accounts for the longest streak of his career, nearly doubling his previous career-long streak (27, twice).
Memories of a record-setting 2014 game between the Carolina Panthers and the Bengals will be stoked when the teams meet in Cincinnati on Sunday. The last time these teams met at the home of the Bengals it finished in a 37-37 tie, and entering Week 9 in 2022 that remains the highest-scoring tie in an NFL game since the NFL and AFL merged in 1970.
The New England Patriots are 4-4 for the fifth time in the Bill Belichick era (since 2000) as they approach a home game against the Indianapolis Colts (3-4-1). The other four times the Patriots started 4-4 under Belichick, they made the playoffs three times (2001, 2005, 2021) and missed the playoffs once (2002). Between the regular season and playoffs, Belichick owns an 18-9 career record against the Colts, with only Don Shula (36 wins as coach of the Dolphins from 1970 to 1995) having achieved more such wins.