The hosts ended the day 300-8 off 89.4 overs after being put in to bat by Emerging Ireland.
Anderson, 23, ended the day 101* off 172 balls including 14 fours and was well supported by Captain Nyeem Young who made 80 off 115 balls including seven fours and five sixes.
Matthew Nandu and centurion from the first game, Joshua Bishop, also made solid contributions with 35 and 22, respectively.
Tom Mayes has so far grabbed 3-62 off 21 overs while Michael Frost and Matthew Foster have taken 2-71 from 25 overs and 2-90 from 23.4 overs, respectively.
Full Scores:
West Indies Academy 300-8 off 89.4 overs (Kevlon Anderson 101*, Nyeem Young 80, Tom Mayes 3-62, Michael Frost 2-71)
The Academy entered day four 148-3 off 28 overs, needing a further 93 runs to make their Irish counterparts have to chase a target.
The tourists were eventually bowled out for 268 in 73.3 overs, leaving Emerging Ireland needing just 28 to win.
Ackeem Auguste, who started the day 70*, was eventually dismissed for a 154-ball 93 including 14 fours while Carlon Bowen-Tuckett made 41 against 5-44 off 17 overs from Matthew Humphreys.
The hosts then needed only 3.5 overs to reach 30-0 with James McCollum and Andrew Balbirnie finishing 14* and 13*, respectively.
Full Scores:
West Indies Academy 200 off 56 overs (Teddy Bishop 69, Nyeem Young 29, Jewel Andrew 27, Ackeem Auguste 26, Matthew Humphreys 5-57, Curtis Campher 3-12) & 268 all out off 73.3 overs (Ackeem Auguste 93, Carlon Bowen-Tuckett 41, Kadeem Alleyne 38, Matthew Humphreys 5-44)
Emerging Ireland 441 all out off 112.5 overs (Andrew Balbirnie 88, Fionn Hand 79, Andy McBrine 64, Paul Stirling 32, Teddy Bishop 2-35, Nyeem Young 2-55, Kelvin Pittman 2-65, Joshua Bishop 2-72) & 30-0 off 3.5 overs
Chasing 344 for victory on Friday, the tourists were eventually dismissed for 271 in 56.4 overs.
Openers Kadeem Alleyne and Ackeem Auguste did the bulk of the scoring with a 151-run opening wicket partnership but their wickets in quick succession dashed the hopes of the West Indians pulling off a successful chase.
Alleyne fell narrowly short of a maiden first class hundred with an 84-ball 93 including nine fours and four sixes while Auguste hit a patient 82-ball 47.
Joshua Bishop was also a key contributor with the bat with 42 off 40 balls including six fours and a pair of sixes.
Leg spinner Gavin Hoey was the pick of the Emerging Ireland bowlers with 4-81 from 19 overs while Matthew Humphreys and Liam McCarthy took 3-44 from 8.4 overs and 3-49 from 17 overs, respectively.
Earlier in the game, Emerging Ireland batted first and posted 283 from 91.3 overs in their first innings after being put in to bat before the West Indies Academy replied with a disappointing 214 in 49.1 overs.
The Irish responded to that with 274 off 74 overs in their second innings leaving the West Indies Academy needing 344 for victory.
The second Four-Day game takes place from June 25-28 in Belfast.
Full Scores:
Emerging Ireland 283 off 91.3 overs (Christopher De Freitas 88, Morgan Topping 45*, Thomas Mayes 42, Johann Layne 4-84, Nyeem Young 3-73) & 274 off 74 overs (Cade Carmichael 92, Stephen Doheny 41, Gavin Hoey 37, Johann Layne 5-39, Onaje Amory 2-88)
West Indies Academy 214 off 49.1 overs (Nyeem Young 48*, Kadeem Alleyne 47, Jordan Johnson 33, Thomas Mayes 4-61, Liam McCarthy 3-62, Matthew Humphreys 2-44) & 271 off 56.4 overs (Kadeem Alleyne 93, Ackeem Auguste 47, Joshua Bishop 42, Gavin Hoey 4-81, Matthew Humphreys 3-44, Liam McCarthy 3-49)
At stumps on day three, the West Indies Academy were 148-3 off 28 overs, trailing their Irish counterparts by 93 runs in their second innings.
Ackeem Auguste ended the day 70* off 91 balls including 11 fours while opening partner Kadeem Alleyne contributed a run-a-ball 38 including five fours and a six.
Earlier, the hosts were dismissed for 441 in 112.5 overs after starting the day 397-7 off 103 overs.
Fionn Hand, who started day three on 61* ended up being dismissed for 79.
The bulk of the Irish run scoring came from captain Andrew Balbirnie who hit 88 off 134 balls on Wednesday. He was well supported by Andy McBrine who hit 64 and James McCollum who hit 40.
Kelvin Pittman, Nyeem Young, Joshua Bishop and captain Teddy Bishop all took two wickets, each.
The Academy were dismissed for 200 in their first innings after winning the toss and batting first on Tuesday.
Teddy Bishop was the main scorer in that batting effort with 69 while Nyeem Young (29), Jewel Andrew (27) and Ackeem Auguste (26) all got starts.
Full Scores:
West Indies Academy 200 off 56 overs (Teddy Bishop 69, Nyeem Young 29, Jewel Andrew 27, Ackeem Auguste 26, Matthew Humphreys 5-57, Curtis Campher 3-12) & 148-3 off 28 overs (Ackeem Auguste 70*, Kadeem Alleyne 38)
Emerging Ireland 441 all out off 112.5 overs (Andrew Balbirnie 88, Fionn Hand 79, Andy McBrine 64, James McCollum 40, Paul Stirling 32, Teddy Bishop 2-35, Nyeem Young 2-55, Kelvin Pittman 2-65, Joshua Bishop 2-72)
Campbell, who is hoping to retain his place in the West Indies team for the Test series against Sri Lanka later this month, scored 129 from 253 balls from which he hit 15 fours and three sixes in his more than five-hour stay at the crease.
He partnered with Captain Roston Chase to put on a fourth-wicket stand of 183 after Jayden Seales and Preston McSween had combined to reduce the side to 53-3. Seales accounted for the wickets of Shayne Moseley for three and Sunil Ambris for a duck to have Chase XI in trouble early at 12 for 2.
Campbell and Nkrumah Bonner then put on 41 for the third wicket before McSween dismissed the latter for 16.
Campbell and Chase took the score to 236 when Chase fell to Kavem Hodge for 75. He struck 10 fours in the innings that lasted for 208 minutes during which he faced 159 deliveries. Campbell eventually fell to the bowling of Rahkeem Cornwall after he and Jermaine Blackwood had put on 16 for the sixth wicket.
Blackwood, meantime, remained unbeaten on 18 at the close. Imran Khan is with him on three.
Seales, who also dismissed Raymon Reifer for 2, was the best of the bowlers taking 3-42 while McSween, who claimed the wickets of Bonner and Jahmar Hamilton returned figures of 2-40.
