Sources have informed ESPN's Adam Schefter that Parker will be traded to the Patriots along with a 2022 fifth-round draft pick in exchange for a 2023 third-round pick.
New England are set to receive a compensatory third-round pick next year after losing J.C. Jackson in free agency.
The Patriots are well stocked with wide receivers, as Parker would join Jakobi Meyers, Kendrick Bourne, Nelson Agholor, N'Keal Harry, Ty Montgomery, Kristian Wilkerson and Malcolm Perry in New England.
Parker finished last season with 40 catches for 515 yards and two touchdowns from 10 appearances.
Miami last month pulled off a blockbuster trade to acquire Tyreek Hill from the Kansas City Chiefs.
That means if you have already booked your place in the playoffs, then the pressure is off somewhat and you don't have to worry about getting the line-up balance exactly right.
However, if you are still fighting to get into the postseason, it is all or nothing and having the perfect line-up is imperative.
Here we try to offer guidance as to who should be starting in this most important of weeks, highlighting four players and one defensive unit that are worthy of being trusted in the regular-season finale.
QB Kirk Cousins - Minnesota Vikings
The Vikings' offense is rolling and Cousins has posted back-to-back 300-yard games in which he has thrown for three touchdowns, though he has lost a fumble in each.
There is a strong chance that run continues against the one-win Jacksonville Jaguars, who are allowing the third-most fantasy points per game to opposing quarterbacks. Look for Cousins to take full advantage of an extremely favourable matchup and further boost Minnesota's playoff hopes.
RB: Raheem Mostert - San Francisco 49ers
Like the Vikings, the 49ers kept their season alive with a win in Week 12, with Mostert marking his return from an ankle injury with a touchdown against the Los Angeles Rams.
It was otherwise tough sledding for Mostert, who finished with 43 yards against a stingy Rams run defense.
The Buffalo Bills should present a less daunting challenge in that regard. They are 25th in the NFL in rushing yards allowed per game and only seven teams have conceded more fantasy points to opposing running backs.
This is a matchup in which Mostert should return to top form.
WR: DeVante Parker - Miami Dolphins
Parker is coming off an eight-catch, 119-yard game against the lowly New York Jets and faces another accommodating defense in Week 13.
The Bengals are allowing 25.1 fantasy points per game to opposing receivers and, after being targeted 14 times in the win over the Jets, Parker is likely to have plenty of opportunities to exploit the Cincinnati defense.
TE: Trey Burton - Indianapolis Colts
For fantasy managers in the unfortunate position of having to consistently stream tight ends, Burton stands out as an excellent option this week.
He has a touchdown in each of his past two games and gets the chance to go against a vulnerable Houston Texans defense that is 23rd in the league in passing yards allowed per game.
D/ST: Pittsburgh Steelers
If you have the Steelers' defense in fantasy, you are starting them. However, it is worth highlighting the extent of the appeal of their Week 13 matchup with the Washington Football Team.
Washington quarterback Alex Smith has started three games and has been pressured on 29.5 per cent of his dropbacks this season, the second-highest rate in the NFL. He has also been intercepted five times in as many appearances in 2020.
Pittsburgh lead the NFL with a pressure rate of 33.3 per cent and have the most takeaways in the NFL with 23. The Steelers' defense should feast en route to another victory in a campaign many expect to end in a Super Bowl appearance.
