Charles made a 21-ball 40 opening the batting including four fours and two sixes while skipper Powell, batting at five, hit 35 off just 15 balls including one four and four sixes to help the Bulls post an intimidating 126-6 off their 10 overs after being put in to bat.
Englishman James Vince also showed good form with 37 off 14 balls. Obed McCoy and Junaid Siddique had identical figures of 2-18 from two overs.
Chennai’s chase then came up significantly short, being bowled out for just 61 in 8.5 overs.
Only Mohammad Nabi was able to crack double figures with 25 as Fazalhaq Farooqi (2-8 from two overs), Muhammad Rohid (2-14 from two overs), Naveen-ul-Haq (2-22 from two overs) and Ravi Bopara (2-4 from five balls) combined to produce an excellent display of bowling.
The win was Bulls' third in a row, and placed them comfortably at the top of the table, at least for the time being.
Tigers were going fine at 28 for 2 after three overs, and with Jordan Cox, David Miller and Dasun Shanaka, among others, to follow, looked set to put up another big total after scoring 143 for 4 in their win over Dubai Gladiators on Thursday.
But Gleeson changed the script in the space of five balls in the fourth over, getting rid of Miller, Shanaka and Cox, in that order, to leave Tigers completely off-kilter at 29 for 5.
Between Daniel Sams (20 not out in 15 balls) and Carlos Brathwaite (21 in 17), Tigers did fight back to get to 81 for 7, but it was never going to be enough against Bulls' powerful batting line-up.
Quinton de Kock and Johnson Charles fell inside two overs, but James Vince (17 in nine), Rilee Rossouw (21* in 11) and captain Rovman Powell (37* in 11) made sure Bulls got to the target quickly - in just six overs.
For Tigers, it was a second loss in three games, and at the end of it, they were placed seventh on the eight-team table.
Earlier on Saturday, explosive 30s from captain Nicholas Pooran and Tom Kohler-Cadmore, followed by Andre Fletcher's 12-ball 41, set up a crushing win for Deccan Gladiators over Team Abu Dhabi.
Pooran dashed out of the blocks taking left-arm finger-spinner Roelof van der Merwe for two fours and two sixes in the first over. Rumman Raees then dealt a double-blow, removing both Pooran and Andre Russell off successive balls in the fourth over, but Kohler-Cadmore and Fletcher proceeded to re-establish Gladiators' dominance.
Six of the 12 balls that Fletcher faced were sent to the boundary, including five sixes. Fletcher, Fabian Allen and Kohler-Cadmore all fell in quick succession, but David Wiese provided the final flourish with 15 off six balls.
Abu Dhabi started their chase shakily, losing their top three inside five overs. Leus du Plooy (25), Colin Ingram (19) and captain Dwaine Pretorius (9), fought back to lend some respectability to the scorecard. Sri Lankan slinger Nuwan Thushara, who plays for Jaffna Kings in the LPL, was the pick of the bowlers for Gladiators, coming away with 2 for 5 in his two overs.
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If you score 98 for 4 in a ten-overs-a-side tournament where three figures are breached quite often, you expect to have it tough in the second half, but it was certainly not the case on the day for Strikers at the Zayed Cricket Stadium on Monday.
Two wickets fell in the first over of the chase, to Akeal Hosein (3 for 7), one each in the second and third, and three in the fifth to Chamika Karunaratne (3 for 6). That was the end of the specialist batters bar Bopara, who was the only Bulls batter to get into double-digits with 16.
The Bulls were bowled out with three balls left in the innings after four batters fell for ducks.
In the first half, Rahmanullah Gurbaz dominated proceedings with a 24-ball 49 not out, as Strikers reached what was a just-about-par score of 98… it proved more than three times what Bulls could manage on the day.
Bulls have now lost two on the bounce after starting with three wins in a row, and are still up at No. 3 on the table, while Strikers, after starting with a loss, have now won three in a row.
Russell, who was disappointing during the ICC T20 World Cup in the UAE mere weeks ago, hit nine fours and seven sixes in a 32-ball 90 that propelled the Gladiators to 159-0, a total that proved unreachable from Dwayne Bravo’s Bulls.
By comparison, Russell’s opening partner Tom Kohler-Cadmore, faced four fewer balls and hit three fours and three sixes to his unbeaten 59.
Together, they plundered the Bulls’ bowling attack that comprised Romario Shepherd (0-29), Dominic Drakes (0-33) Ravi Rampaul (0-28) and Bravo (0-32).
Russell would complete his standout performance taking 1-25 as the Delhi Bulls, which had won the toss and chose to field, could only muster 103-7 from their 10 overs, despite a 20-ball 42 from Chandrapaul Hemraj.
It was virtually a solo effort from Hemraj, who hit two fours and five sixes in his knock as Romario Shepherd (9) was the only other Caribbean player who contributed with the bat as Sherfane Rutherford, Drakes and Bravo all failed to score.
Fittingly, Russell bowled Shepherd with the last ball of the match.
Odean Smith played his part taking 2-20, similar figures to Hasaranga da Silva. Tymal Mills was the best of the Gladiator bowlers with extraordinary figures of 2-4 from his two overs.
