Dani Carvajal impressed in El Clasico at the weekend, with the Real Madrid right-back slotting into a defence in front of Crystal Palace's Spanish goalkeeper Vicente Guaita.
Marcos Alonso is in the team after returning to form with Chelsea, the full-back scoring both goals as the Blues drew with Bournemouth.
The other Spaniard in the starting line-up is Atletico Madrid's Saul Niguez, while Ismaila Sarr takes a place on the bench after he stole the show in Watford's shock 3-0 win over Liverpool, whose 44-match unbeaten run in the Premier League ended abruptly at Vicarage Road.
Below, we have the entire squad.
TEAM OF THE WEEK
GK:Vicente Guaita (Crystal Palace) – 82
RB:Dani Carvajal (Real Madrid) – 87
CB:Kostas Manolas (Roma) – 86
LB: Ramy Bensebaini (Borussia Monchengladbach) – 84
RM:Calvin Stengs (AZ) – 84
CM:Saul Niguez (Atletico Madrid) – 87
LWB:Marcos Alonso (Chelsea) – 86
LW:Philippe Coutinho (Bayern Munich) – 89
LM:Fabian Orellana (Eibar) – 84
ST:Duvan Zapata (Atalanta) – 86
ST:Dario Benedetto (Marseille) – 84
SUBSTITUTES
GK: Predrag Rajkovic (Reims) – 79
LB:Marcal (Lyon) – 81
RM:Ismaila Sarr (Watford) – 82
CM: Teji Savanier (Montpellier) – 82
CF: Andre-Pierre Gignac (Tigres) – 83
ST:Nikola Kalinic (Roma) – 82
ST:Dieumerci Mbokani (Antwerp) – 82
RESERVES
RB:Matias Rodriguez (Deportes Nunoa) – 78
LM: Danny Blum (Bochum) – 78
ST: Klauss (LASK) – 77
GK:Daniel Akpeyi (Kaizer Chiefs) – 75
LF: Max Burgess (Western United) – 73
The Spain international rifled home the second goal in Wednesday's routine 4-0 win over Real Zaragoza as Madrid cruised into the quarter-finals of the Copa del Rey.
Many have questioned Vazquez's role in the team, but he was praised by boss Zinedine Zidane for his display against Zaragoza and the winger is glad to have proved himself.
Asked how he reacts to the criticism directed his way, the 28-year-old told reporters: "I isolate myself from it. I'm a Madrid player and I know what I stand for.
"What you can't do is doubt yourself."
Madrid have gone 20 games without defeat in all competitions since losing 2-0 to Real Mallorca on October 19 and they lead the way by three points at the top of LaLiga.
Next up is a home match with city rivals Atletico Madrid on Saturday and Vazquez said: "The game in Mallorca was a turning point. It's brought good performances and good results.
"Playing [Atletico] is always difficult. They're not going to make things easy for us."
Raphael Varane, Vinicius Junior and Karim Benzema were also on target at the Estadio La Romareda as Madrid made it seven wins in a row.
Zidane's men remain on course for three more trophies, having already won the Supercopa de Espana earlier this month, and defender Dani Carvajal has set his sights on a clean sweep.
"We have three matches left [in the Copa] to be in the final and we are going for it," he said.
"We will take it step by step. On Saturday there's an important match - we want to keep this going. It's a special match."
With the result, the Reggae Boyz finish second in the group with a 2W-1D-0L record, clinching a berth in the quarterfinals, and will face the first-place team from Group D next Sunday at TQL Stadium in Cincinnati, Ohio.
The first half hour was full of chances for Jamaica, mostly coming from a series of deep crosses but with no end product, as the Sugar Boyz defence did well to stay compact and maintain their lines.
The Reggae Boyz broke the deadlock right before the 30-minute mark, as a deep cross from Leon Bailey reached Kaheem Parris, who tried to play back across goal only for Saint Kitts and Nevis goalkeeper Julani Archibald to deflect the ball over the line for a 1-0 Jamaica lead.
Jamaica then added a second right before the break to double their advantage, as Bailey played a slick back-heel to Jonathan Russell’s whose right-footed finish beat Archibald for a 2-0 lead.
The momentum stayed with Jamaica and soon it was 3-0 on a tidy finish from DiShon Bernard after a pass from Shamar Nicholson in the 49’.
St Kitts and Nevis did get a pair of good looks at goal during the contest from Romaine Sawyers, one in each half, but the Sugar Boyz attacking player was unable to convert.
Jamaica kept their foot on the gas and quickly tacked on another two goals to make it a 5-0 lead. Daniel Johnson fired in one in the 72’ after an initial block by substitute goalkeeper Jamal Jeffers, followed by a good finish from Cory Burke in the 74’.
From there, the Jamaican defence saw things out the rest of the way to nail down the clean sheet victory and a place in the next round.