Swiatek, 21, is seeking her fourth grand slam title and her first at the Australian Open, having already won the French Open twice before claiming her first US Open crown this past season.
Against Osorio, it was Swiatek's ability to consistently return that was the difference, holding the Colombian to just a 31 per cent success rate on her service points in the opening set (eight-of-26).
It resulted in a lightning-quick start for the Polish superstar, winning the first four games of the match, and despite giving back a couple breaks of serve, Swiatek did not allow Osorio to hold serve a single time in the opening frame.
Osorio was able to finally hold serve to begin the second set, before Swiatek again rattled off four consecutive games to collect a double-break and a winning lead.
In a remarkably clean performance from the tournament favourite, Swiatek landed 80 per cent of her first serves fair while committing no double faults, and both players finished with more winners than unforced errors.
With the victory, Swiatek will now face the winner between Cristina Bucsa and Bianca Andreescu in the third round.
Data Slam: Swiatek in legendary company
Swiatek has now won 53 of her first 65 grand slam matches – the sixth-best total through 65 attempts in the Open Era.
She trails only Margaret Court (61), Monica Seles (60), Chris Evert (57), Martina Hingis (56), Billie Jean King (56) and Tracy Austin (54).
WINNERS/UNFORCED ERRORS
Swiatek – 19/16
Osorio – 16/14
ACES/DOUBLE FAULTS
Swiatek – 0/0
Osorio – 0/2
BREAK POINTS WON
Swiatek – 6/8
Osorio – 3/5
Ons Jabeur eased past Camila Osorio in straight sets to progress to the next round of the Nottingham Open.
The three-time grand slam champion returned to the East Midlands for the first team since 2014, and got her grass court season off to a winning start with a 6-2 6-3 win over the Colombian.
It was the perfect start for the world number 10, who earned a break point in the opening game before going on to win the first set, but the Tunisian was made to work to secure her triumph.
Osorio matched Jabeur early on, but the top seed at the tournament showcased her class to come through the encounter, building on her quarter-final run at the French Open as her preparations for Wimbledon continue.
Jabeur will face Linda Fruhvirtova in the next round of the competition.
Data Debrief: Top seed Jabeur through to next round
The world number 10 was at her clinical best, winning 84 per cent of her first serve points.
Jabeur's win saw her unbeaten record continue against Osorio, having last prevailed at Roland-Garros in May.
Fourth seed Martic made a good start against American opponent Alycia Parks on Wednesday, only to lose 2-6 7-6 (7-3) 6-2.
Sixth seed Sherif was more convincingly beaten as she fell to Czech teenager Linda Noskova 6-3 6-2.
Noskova will face Camila Osorio in the quarter-finals after the Colombian came out on top in a tight clash with Jule Niemeier 7-6 (7-5) 7-5
In the two remaining first-round matches, Jasmine Paolini defeated Rebeka Masarova 6-3 6-2, while Belgian Alison Van Uytvanck will face top seed Caroline Garcia in the last 16 after beating Tamara Korpatsch 6-2 6-4.
At the Thailand Open, it was not much better for seeded players as Anna Kalinskaya and Linda Fruhvirtova both exited on Wednesday.
Fourth seed Kalinskaya was overwhelmed 6-0 in the opening set against Lesia Tsurenko, only to win a tie-break in the second.
The unseeded Ukrainian ultimately won out, though, sealing a 6-0 6-7 (3-7) 6-4 victory to reach the quarter-finals.
Eighth seed Fruhvirtova also managed to level after falling a set behind, and also could not find the win as the 17-year-old was beaten by Tamara Zidansek 6-3 4-6 6-4.
The Slovenian will face Zhu Lin in the last eight after her straight-sets win over Jang Su-jeong, but there was one win for a seed as Xinyu Wang (seventh seed) beat Mirjam Bjorklund 6-3 6-3.
The American beat Maryna Zanevska 6-3 7-6 (7-4) on Saturday, hitting 35 winners and 13 aces on the way to victory.
Parks has risen through the ranks in the last year, and explained how a laid back attitude has been the secret to her success in France.
"I think the key was just staying focused, and taking my time out there," Parks said after her win. "Every time I got ahead of myself, I would kind of lose points, so I would tell myself to slow down.
"This whole week, I'm kind of relaxed this week and just kept playing my game and doing me."
The 22-year-old will face Garcia on Sunday after she eased to a 6-2 6-2 win against Camila Osorio in just an hour and 12 minutes.
At the Thailand Open, Lesia Tsurenko will take on China's Zhu Lin in the final after the Ukrainian came past top seed Bianca Andreescu.
The Canadian retired hurt in the second set, though Tsurenko already led 7-5 4-0.
"The way [Andreescu was] playing every point, like she has an idea in every point, so of course she's an amazing player," Tsurenko said. "It was a big challenge for me to handle this, and I was just saying to myself that I have to keep fighting, and this is probably the main key that worked today for me."
Zhu defeated compatriot Xinyu Wang 6-2 6-4 to advance to Sunday's final.
It was an ominous start for Cirstea, being broken to love in the opening game, but she stuck with second seed Sabalenka and broke back, before ultimately being pipped to the first set by the impressive Belarusian.
The key was on break points, with Sabalenka claiming all five that she won against the Cirstea serve, while saving six of eight on her own as she ultimately eased to victory.
Sabalenka now has 26 wins on clay in the WTA since 2021, with only Ons Jabeur (37), Iga Swiatek (34), Paula Badosa (31) and Coco Gauff (28) having more during this time.
Gauff also advanced after a routine 6-4 6-1 win over Irene Burillo Escorihuela, making the sixth seed in Madrid the first player to win 35 WTA-1000 main draw matches as a teenager since 2009.
Ninth seed Maria Sakkari defeated Arantxa Rus 6-4 6-4 and fifth seed Caroline Garcia also had few problems against Yulia Putintseva, winning 6-3 6-4.
However, it was not a good day for 10th seed Petra Kvitova, who was beaten 7-6 (11-9) 6-1 by Jule Niemeier, while 13th seed Beatriz Haddad Maia also lost, 7-6 (8-6) 6-3 to Mirra Andreeva and 20th seed Donna Vekic was eliminated in straight-sets by Rebeka Masarova.
Jelena Ostapenko took just 61 minutes to get past Linda Fruhvirtova 6-0 6-3, and will face 14th seed Liudmila Samsonova next, who did not take much longer to see off Maryna Zanevska 6-2 6-3.
There were also wins for Elise Mertens, Badosa, Camila Osorio, Shelby Rogers, Mayar Sherif, Magda Linette and Irina-Camelia Begu.
