The Academy entered day four 148-3 off 28 overs, needing a further 93 runs to make their Irish counterparts have to chase a target.
The tourists were eventually bowled out for 268 in 73.3 overs, leaving Emerging Ireland needing just 28 to win.
Ackeem Auguste, who started the day 70*, was eventually dismissed for a 154-ball 93 including 14 fours while Carlon Bowen-Tuckett made 41 against 5-44 off 17 overs from Matthew Humphreys.
The hosts then needed only 3.5 overs to reach 30-0 with James McCollum and Andrew Balbirnie finishing 14* and 13*, respectively.
Full Scores:
West Indies Academy 200 off 56 overs (Teddy Bishop 69, Nyeem Young 29, Jewel Andrew 27, Ackeem Auguste 26, Matthew Humphreys 5-57, Curtis Campher 3-12) & 268 all out off 73.3 overs (Ackeem Auguste 93, Carlon Bowen-Tuckett 41, Kadeem Alleyne 38, Matthew Humphreys 5-44)
Emerging Ireland 441 all out off 112.5 overs (Andrew Balbirnie 88, Fionn Hand 79, Andy McBrine 64, Paul Stirling 32, Teddy Bishop 2-35, Nyeem Young 2-55, Kelvin Pittman 2-65, Joshua Bishop 2-72) & 30-0 off 3.5 overs
At stumps on day three, the West Indies Academy were 148-3 off 28 overs, trailing their Irish counterparts by 93 runs in their second innings.
Ackeem Auguste ended the day 70* off 91 balls including 11 fours while opening partner Kadeem Alleyne contributed a run-a-ball 38 including five fours and a six.
Earlier, the hosts were dismissed for 441 in 112.5 overs after starting the day 397-7 off 103 overs.
Fionn Hand, who started day three on 61* ended up being dismissed for 79.
The bulk of the Irish run scoring came from captain Andrew Balbirnie who hit 88 off 134 balls on Wednesday. He was well supported by Andy McBrine who hit 64 and James McCollum who hit 40.
Kelvin Pittman, Nyeem Young, Joshua Bishop and captain Teddy Bishop all took two wickets, each.
The Academy were dismissed for 200 in their first innings after winning the toss and batting first on Tuesday.
Teddy Bishop was the main scorer in that batting effort with 69 while Nyeem Young (29), Jewel Andrew (27) and Ackeem Auguste (26) all got starts.
Full Scores:
West Indies Academy 200 off 56 overs (Teddy Bishop 69, Nyeem Young 29, Jewel Andrew 27, Ackeem Auguste 26, Matthew Humphreys 5-57, Curtis Campher 3-12) & 148-3 off 28 overs (Ackeem Auguste 70*, Kadeem Alleyne 38)
Emerging Ireland 441 all out off 112.5 overs (Andrew Balbirnie 88, Fionn Hand 79, Andy McBrine 64, James McCollum 40, Paul Stirling 32, Teddy Bishop 2-35, Nyeem Young 2-55, Kelvin Pittman 2-65, Joshua Bishop 2-72)
Balbirnie plundered 77 from 55 balls, including 10 fours and two sixes, and his partnership of 76 with Harry Tector (36) edged Ireland closer to victory.
Curtis Campher (15*) and Gareth Delany (10*) saw them over the line to secure the win with one ball to spare.
Despite an early setback, Pakistan started strong, with Babar Azam hitting 57 and Saim Ayub adding 45.
However, Craig Young’s strong performance saw him take 2-27 as Ireland took control to limit the visitors in the later stages as Azam Khan and Shadab Khan both walked without getting any runs.
The sides will meet again at the Dublin venue on Sunday and Tuesday.
Data Debrief:
Ireland achieved their target of 183 against Pakistan successfully today, making it their highest run chase against a full-member side in men's T20Is.
Ireland's first win against Pakistan came at the 2007 World Cup and 17 years later they secured a first victory over them in T20 cricket.
On the back of 94 from Paul Sterling and 48 from Kevin O’Brien, the Irish posted a competitive 208 for 7 before restricting the Windies to 204 for 7. Along the way, the Irish, who lost their first wicket with 154 runs on the board, set the highest total ever in the powerplay.
The win served as a tonic of sorts for the visitors who were defeated 3-0 by the Windies in the recent One Day International series between the teams.
“It’s great to get a win but you want to win the series and make history, so if we can do that in the next two games we’ll go home very happy,” Balbirnie said.
“We came so close in that second ODI and it may have affected us in the third ODI. So, to come out here and show the bottle and win against one of the top teams in T20 cricket was great for the team.”
The Windies and Ireland will face off in the second T20I on Saturday at Warner Park.