Arguably the best stretch of Mecole Hardman's career has been interrupted, with the Kansas City Chiefs wide receiver set to miss the next month after being placed on injured reserve on Thursday.

Hardman, 24, scored a touchdown in three consecutive games for the first time in his career, starting in Week 6 against the Buffalo Bills, before also finding the endzone against the San Francisco 49ers and Tennessee Titans.

He was listed on the injury report with an abdominal injury following the win against the Titans in Week 9, before missing the Chiefs' Week 10 win against the Jacksonville Jaguars.

Unfortunately, his prospect of a quick return evaporated during the week off, with the team deciding he is far enough away from full health to warrant the use of the injured reserve.

He will be ineligible to play for at least the next four weeks, and it comes at a time when the Chiefs' top receiver JuJu Smith-Schuster is under the league's concussion protocol.

Smith-Schuster is also unlikely to play in Week 11 against the Los Angeles Chargers, which means there will be an increased responsibility for star tight end Travis Kelce, as well as an opportunity for recently acquired Kadarius Toney.

Toney, a first-round draft pick in 2021, arrived in Kansas City less than a month ago from the New York Giants in exchange for a third-round pick and a sixth-round pick.

In his second game for the Chiefs, Toney caught four passes for 57 yards and his first touchdown from quarterback Patrick Mahomes, also receiving two carries for 33 yards.

We are somehow already at Week 10 in the NFL season, all wondering where the time actually does go.

Two of the shining lights of the campaign face off in Buffalo as the Bills host the Minnesota Vikings.

History will be made in Munich as the Tampa Bay Buccaneers face the Seattle Seahawks in the first-ever regular season NFL game played in Germany, while the San Francisco 49ers will look to continue their return to winning ways against the Los Angeles Chargers.

Stats Perform takes a closer look at the numbers behind some of Sunday's NFL clashes.

Minnesota Vikings (7-1) @ Buffalo Bills (6-2)

The Vikings have played eight games at Highmark Stadium and have held the Bills to 23 points or fewer in each one, which is the longest streak of allowing 23 points or fewer by a visiting team in the stadium's history.

Minnesota have won six straight games, all by eight points or fewer, tied for the second-longest streak of one-possession wins in NFL history, behind a seven-game streak by the Kansas City Chiefs in 2020.

T.J. Hockenson boasted nine catches on his Vikings debut last week, tying the Bills' Keith McKeller (October 18, 1987) for the most receptions by a tight end on debut with a team in the Super Bowl era.

The Bills have allowed 21 points or fewer in 12 straight regular-season games, the longest streak in franchise history and the second longest by any NFL team over the last 15 seasons (Baltimore Ravens, 13 straight from 2019-20).

Buffalo are allowing just 4.6 points per game in the second half this year. No NFL team has allowed fewer than 5.0 points per game in the second half over a full season since the Carolina Panthers in 1996 (3.5).

Seattle Seahawks (6-3) @ Tampa Bay Buccaneers (4-5)

It should be a great experience in Bavaria, but the Bucs are 0-3 in games played outside the United States (all in London), having been outscored 96-51 in those games. The Seahawks, meanwhile, are 2-0 outside the U.S. (one in Toronto, one in London), outscoring their opponents, 77-20.

Pete Carroll is in his 17th season as an NFL head coach and has had at least six wins in each campaign. The only other coach to have six or more wins in each of his first 17 seasons was Don Shula, who did so in all 33 seasons of his career.

Kenneth Walker III is the first NFL rookie to rush for a touchdown and have his team win in each of his first four career starts since Robert Edwards for the New England Patriots in 1998.

Tom Brady has thrown at least 40 passes with no interceptions in seven consecutive starts. No other QB in NFL history has done that in more than four straight starts.

The Bucs have rushed for 75 or fewer yards in eight straight games, the second-longest streak in the Super Bowl wera behind a nine-game streak by the Cardinals from 1991-92.

Los Angeles Chargers (5-3) @ San Francisco 49ers (4-4)

The Chargers are looking to win their sixth-straight game against the 49ers, which would make them the first team to do so since the Seahawks (nine games from 2014 to 2018).

Justin Herbert was not sacked in the Chargers' recent win against the Atlanta Falcons. The Chargers have allowed the fewest sacks in the league this season (10), and have not allowed 10 or fewer sacks through eight games since the 2008 season (also 10).

Through 40 career starts, Herbert has played a part in 90 touchdowns (82 passing, eight rushing). Only Patrick Mahomes (107), Dan Marino (95) and Kurt Warner (91) accounted for more scores in their first 40 starts.

San Francisco's last five games have all been decided by at least 14 points (3-2 record). They have not had six consecutive such games since an eight-game streak in 1999.

Christian McCaffrey threw for, rushed for and caught a touchdown in San Francisco's win over the Rams. He was the first player to do so since the Chargers' LaDainian Tomlinson completed the feat in Week 6 of the 2005 season.

Elsewhere...

The Jacksonville Jaguars (3-6) will need a plan to deal with Chiefs (6-2) QB Mahomes, who attempted 68 passes (completing 43) in last week's win over the Tennessee Titans, both of which set single-game team records. The only player to attempt more passes in a win in the NFL since 1950 was Drew Bledsoe with 70 in Week 11 of the 1994 season.

Former Chief Tyreek Hill has 1104 receiving yards this season for the Miami Dolphins (6-3), the most by any player through his team's first nine games in the Super Bowl era. Prior to this year, there had only been 11 times a Dolphins receiver recorded 1100 yards in an entire season, and Hill will look to add to those against the Cleveland Browns (3-5).

Last week was Cooper Kupp's 20th career game with at least 100 receiving yards and a touchdown, the most in the NFL since he entered the league in 2017. The only other players with more than 15 such games in that span are Davante Adams (19) and Hill (18), and the Los Angeles Rams (3-5) will need their star to step up again against the Arizona Cardinals (3-6).

Aaron Rodgers' passer rating is at 89.0 this season after posting 111.9 in 2021. The decrease of 22.9 is the largest by a Green Bay Packers quarterback (min. five games played) since Bart Starr from 1966 to 1967 (105.0 to 64.4). With a record of 3-6, the Packers will hope he can improve that against the Dallas Cowboys (6-2).

Patrick Mahomes' extraordinary success with the Kansas City Chiefs has largely been built on his incredible rapport with tight end Travis Kelce.

On Sunday against the Tennessee Titans, it was his connection with an unheralded tight end that proved to critical for Mahomes and Kansas City.

The Chiefs fought back from a 17-9 deficit to see off the Titans 20-17 in overtime and move to 6-2.

Mahomes produced magic with his legs to help the Chiefs tie the game, a 20-yard rush on third-and-17 keeping alive a scoring drive he capped with a 14-yard touchdown run. He then added the two-point conversion on another scramble.

His 68 passes were just two shy of the all-time single-game record. Mahomes completed 43 passes, again two short of the league record, with the gap between his tally and that of Titans rookie Malik Willis (five) representing the largest between two starting quarterbacks in a game.

No completion was more important than Mahomes' 27-yard connection with tight end Noah Gray on third-and-1 from the Tennessee 49-yard line.

Under pressure from Demarcus Walker, Mahomes rolled to his right before deftly evading the defensive lineman and stepping up to fire downfield to Gray, who had uncovered from the coverage of Roger McCreary. Gray leapt to make a juggling catch over the head of McCreary, putting Kansas City on the edge of the red zone.

Though the Chiefs could not clinch the game with a touchdown, Harrison Butker converted a 28-yard field goal and the defense stopped Willis and the Titans in four plays on the subsequent series to wrap it up.

"It's funny," Mahomes said. "I think I said it in training camp: I feel like I don't target Noah enough because a lot of times plays are called either to him or he's one of the options I can give him a chance on. And it seems like I don't throw it to him.

"He's always open — and so as the season's going on and as our careers go on I want to give him more and more chances, because I think he can be a big part of this offense. 

"That whole tight end room has been great for us this season. But for [Gray] to make that catch in that moment? I mean, that was a tough catch that he made; that was a big one for us. That was probably the reason that we were able to get down there and win."

Asked about his third-down run that set the comeback in motion, Mahomes replied: "I definitely saw a lane to get it close enough that I thought we'd be able to go for it [on fourth down].

"When you're in that situation, you know that if you can get it to a fourth-and-5, fourth-and-4, coach Reid's probably going to give you a chance there.

"And then as I was running, I felt the – I think it was the safety — kind of overpursuing so I kind of shot my shot and went out there. I actually tried to get outside again which didn’t work out for me; I’m not fast enough.

"But it was a good play and like I said we just battled at the end of the day. It wasn't like we were designing it up we were just going out there and trying to make some stuff happen."

Mahomes is the NFL king of making stuff happen, and his primetime heroics in Week 9 moved the Chiefs level with the 6-2 Buffalo Bills at the top of the AFC. The Chiefs are in prime position to make another run at a Super Bowl title.

Patrick Mahomes' extraordinary success with the Kansas City Chiefs has largely been built on his incredible rapport with tight end Travis Kelce.

On Sunday against the Tennessee Titans, it was his connection with an unheralded tight end that proved to critical for Mahomes and Kansas City.

The Chiefs fought back from a 17-9 deficit to see off the Titans 20-17 in overtime and move to 6-2.

Mahomes produced magic with his legs to help the Chiefs tie the game, a 20-yard rush on third-and-17 keeping alive a scoring drive he capped with a 14-yard touchdown run. He then added the two-point conversion on another scramble.

His 68 passes were just two shy of the all-time single-game record. Mahomes completed 43 passes, again two short of the league record, with the gap between his tally and that of Titans rookie Malik Willis (five) representing the largest between two starting quarterbacks in a game.

No completion was more important than Mahomes' 27-yard connection with tight end Noah Gray on third-and-1 from the Tennessee 49-yard line.

Under pressure from Demarcus Walker, Mahomes rolled to his right before deftly evading the defensive lineman and stepping up to fire downfield to Gray, who had uncovered from the coverage of Roger McCreary. Gray leapt to make a juggling catch over the head of McCreary, putting Kansas City on the edge of the red zone.

Though the Chiefs could not clinch the game with a touchdown, Harrison Butker converted a 28-yard field goal and the defense stopped Willis and the Titans in four plays on the subsequent series to wrap it up.

"It's funny," Mahomes said. "I think I said it in training camp: I feel like I don't target Noah enough because a lot of times plays are called either to him or he's one of the options I can give him a chance on. And it seems like I don't throw it to him.

"He's always open — and so as the season's going on and as our careers go on I want to give him more and more chances, because I think he can be a big part of this offense. 

"That whole tight end room has been great for us this season. But for [Gray] to make that catch in that moment? I mean, that was a tough catch that he made; that was a big one for us. That was probably the reason that we were able to get down there and win."

Asked about his third-down run that set the comeback in motion, Mahomes replied: "I definitely saw a lane to get it close enough that I thought we'd be able to go for it [on fourth down].

"When you're in that situation, you know that if you can get it to a fourth-and-5, fourth-and-4, coach Reid's probably going to give you a chance there.

"And then as I was running, I felt the – I think it was the safety — kind of overpursuing so I kind of shot my shot and went out there. I actually tried to get outside again which didn’t work out for me; I’m not fast enough.

"But it was a good play and like I said we just battled at the end of the day. It wasn't like we were designing it up we were just going out there and trying to make some stuff happen."

Mahomes is the NFL king of making stuff happen, and his primetime heroics in Week 9 moved the Chiefs level with the 6-2 Buffalo Bills at the top of the AFC. The Chiefs are in prime position to make another run at a Super Bowl title.

The Kansas City Chiefs came from behind to defeat the Tennessee Titans 20-17 in overtime on Sunday thanks to more Patrick Mahomes' heroics.

Despite Mahomes proving to be the difference late, he was bottled up early by a sharp Titans defense, holding the Chiefs to just nine points in the first three quarters.

On the back of their strong defense, the Titans built a 14-9 lead at half-time as superstar running back Derrick Henry bulled his way into the endzone for two touchdowns.

Mahomes completed a first-half touchdown pass to Mecole Hardman, but a third-quarter field goal from the Titans had them trailing 17-9 heading into the fourth period.

With the game on the line, needing a touchdown and a two-point conversion to tie, Mahomes manufactured a 13-play, 93-yard drive, culminating in a 14-yard rushing touchdown from the Chiefs quarterback to convert on third-and-nine. He then also ran in the two-point conversion.

Mahomes completed passes to four different players in his one overtime drive, highlighted by a 27-yard jump-ball to Noah Gray to convert a third-and-inches and move into the redzone, before also converting a fourth-and-one to JuJu Smith-Schuster.

Ultimately they settled for a field goal, forcing Titans rookie quarterback Malik Willis to at least mount his own field-goal drive to keep the game alive, but the Chiefs defense rose to the occasion for the game-winning stop.

Mahomes ended up completing 43 of his 68 pass attempts for 446 yards, one touchdown and one interception, while also leading the Chiefs in rushing with six carries for 63 yards and a score to tie the game at 17-17.

That was in stark contrast to what the Titans asked Willis to do, as he finished five-of-16 for 80 yards. Henry was the star for Tennessee, rushing 17 times for 115 yards and two touchdowns, giving him nine touchdowns from eight games this season.

After a busy NFL trade deadline, the focus is back on the field this weekend.

Josh Allen faces Zach Wilson as the New York Jets confront a major test of their defense against the soaraway Buffalo Bills, while the Los Angeles Rams will look to keep up their remarkable record against the Tampa Bay Buccaneers.

Could Derrick Henry have another monumental game in him after last week's big effort, and after he dispelled worries about a foot problem?

Stats Perform has taken a look at the numbers ahead of Sunday's games, beginning with the travails of the Brady bunch.

Los Angeles Rams (3-4) at Tampa Bay Buccaneers (3-5)

The Buccaneers are on the slide, and the Rams are just about the nightmare opponents this weekend, judging by recent games between the teams.

Including Los Angeles' win in last season's Divisional Round, the Rams are 9-1 in their last 10 games against the Bucs, and that includes a 5-0 streak in Tampa.

This game is big for both, and for the Bucs it offers a chance to halt a losing sequence of three. They were beaten 27-22 by the Baltimore last week and are on their longest single-season losing run since a dismal four-game run in the 2019 season.

It remains to be seen whether Tom Brady can get them out of this mess. Brady threw for 325 yards and zero interceptions in last week's loss to Baltimore. Across his stellar career, he is 54-7 when throwing 300 yards and no interceptions, but this season he is 1-2 in such games.

Brady might fancy the job against a Rams team who have scored 14 or fewer points and lost by double-digits four times already this season, including last time out in a 31-14 home loss to the San Francisco 49ers.

Rival quarterback Matthew Stafford threw for 187 yards last week on 33 attempts. His team are 2-9 in games where Stafford has thrown the ball at least 30 times and finished with fewer than 200 passing yards.

Buffalo Bills (6-1) at New York Jets (5-3)

The Buffalo Bills are 6-1 for the first time since 1993, the season they last made it through to the Super Bowl. This weekend they go after a fifth win in a row after getting the better of the Green Bay Packers last time out.

What's more, they have strung together a four-game winning streak in road games against the Jets, second only in franchise history to a seven-game streak from 1987 to 1993.

The Bills have outscored this season's opponents by 105 points (203-98) so far, the widest differential in the NFL.

Bills quarterback Josh Allen has urged the Jets to show patience with his struggling counterpart Zach Wilson, who has completed just 54.9 per cent of passes this season, the second-worst rate in the NFL heading into Week 9. Wilson has thrown for 1,048 yards across five games, with three touchdowns and five interceptions, compared to Allen's 2,198 yards for 19 TDs and six interceptions from seven games.

Stefon Diggs has at least 100 yards and a receiving touchdown in three straight games, the longest streak of the Bills wide receiver's career and tied for the longest streak in team history with Elbert Dubenion (1964). The last NFL player with a longer streak was Adam Thielen in 2018 (five). How Diggs fares against Jets rookie cornerback Sauce Gardner will be a factor.

The Jets have already topped last season's four wins, but they are 8-30 against divisional opponents since 2016, the worst record in the NFL.

Tennessee Titans (5-2) at Kansas City Chiefs (5-2)

What does Titans running back Henry have in store for an encore? Henry last week recorded his sixth career 200-yard rushing game, with 219 yards and two touchdowns against the Texans, tying Adrian Peterson and O.J. Simpson for the most all-time. All other active players have combined for just four such games.

The Chiefs will be wary of that threat, and will look to their own WR, JuJu Smith-Schuster, to make his own impact. After failing to reach 90 yards or find the endzone in his first five games this season, Smith-Schuster now has back-to-back games with at least 100 yards and a touchdown. He had not had such a game since Week 8, 2019 and now has eight such games in his career.

The Titans have won four straight regular season matchups with the Chiefs but lost in the 2020 AFC Championship Game in Kansas City.

Their respective 5-2 records this season disguise the fact each of those wins has been relatively close. The Titans and Vikings have only won by single digits this season. Only five teams in NFL history have seen such a streak reach six games – the 2020 Chiefs, 1997 Vikings, 1994 Giants, 1988 Saints and 1986 Giants. Of those, only the Chiefs' streak reached seven.

Elsewhere...

The Miami Dolphins (5-3) will be looking for a fourth consecutive road win against the Chicago Bears (3-5), which would make the Dolphins the first AFC team since the conference came into being in 1970 to have such a streak in Chicago. Miami's Tyreek Hill has gone 52 consecutive receptions without a receiving touchdown. That accounts for the longest streak of his career, nearly doubling his previous career-long streak (27, twice).

Memories of a record-setting 2014 game between the Carolina Panthers and the Bengals will be stoked when the teams meet in Cincinnati on Sunday. The last time these teams met at the home of the Bengals it finished in a 37-37 tie, and entering Week 9 in 2022 that remains the highest-scoring tie in an NFL game since the NFL and AFL merged in 1970.

The New England Patriots are 4-4 for the fifth time in the Bill Belichick era (since 2000) as they approach a home game against the Indianapolis Colts (3-4-1). The other four times the Patriots started 4-4 under Belichick, they made the playoffs three times (2001, 2005, 2021) and missed the playoffs once (2002). Between the regular season and playoffs, Belichick owns an 18-9 career record against the Colts, with only Don Shula (36 wins as coach of the Dolphins from 1970 to 1995) having achieved more such wins.

The Kansas City Chiefs have a bye this week but the team is staying busy, acquiring wide receiver Kadarius Toney from the New York Giants.

The Chiefs sent a 2023 third-round pick and a sixth-round pick in next year's draft to the Giants to complete the trade.

Toney was the 20th overall pick in the 2021 draft by New York, but his career has been marred by injuries so far.

A hamstring issue has sidelined him since Week 2 this season, while oblique and shoulder injuries limited him to just 10 games as a rookie last year.

When healthy, however, the 23-year-old has proven to be a dangerous receiver and should provide Patrick Mahomes with another weapon at his disposal.

In 2021, he hauled in 39 receptions for 420 yards, averaging 6.1 yards after the catch. He has just two catches for zero yards this season.

The Chiefs next play on November 6 against the Tennessee Titans and it is still uncertain when Toney will be able to make his Kansas City debut due to his ailing hamstring.

When Toney does suit up, he will be joining a talented pass-catching corps with receivers JuJu Smith-Schuster, Marquez Valdes-Scantling, Mecole Hardman and tight end Travis Kelce.

By stunningly trading Tyreek Hill in the offseason, the Kansas City Chiefs parted with a player whose unparalleled speed consistently served as their easiest avenue to explosive plays.

Juju Smith-Schuster may have initially seemed a curious fit as his replacement but, after back-to-back 100-yard receiving performances, he is proving to be the ideal number one wideout for the Chiefs to attack how defenses are attempting to defend them in 2022.

While tight end Travis Kelce is Patrick Mahomes' unquestioned top target in the post-Hill era, Smith-Schuster is rapidly developing an increasingly potent rapport with a quarterback who is in a seemingly ceaseless battle with Josh Allen for the title of the league's most frightening signal-caller.

The San Francisco 49ers will spend the early part of the week before Halloween trying to learn the lessons from their previously top-ranked defense's nightmare showing against the Chiefs, one in which Smith-Schuster produced another demonstration of his increasing comfort level in an offense that has designs on overcoming the loss of Hill to right the wrongs of their playoff disappointments in the previous two seasons.

A serial separator

Having caught all five of his targets for 113 yards and a touchdown in the Chiefs' narrow defeat to the Buffalo Bills last week, Smith-Schuster enjoyed another sensational display at Levi's Stadium.

He finished with seven catches on eight targets for 124 yards and a touchdown that was the knockout blow in the Chiefs' 44-23 win over the 49ers.

Smith-Schuster produced a burn, which is when a receiver wins his matchup on a play where he is targeted, on seven of his eight targets against San Francisco and averaged 15.5 burn yards per target. Among receivers targeted at least five times in Week 7, only Jaylen Waddle and Tyler Boyd averaged more as of Sunday.

Those numbers are a continuation of a theme from the Week 6 meeting with the Bills, in which Smith-Schuster registered a burn on each of his targets and averaged 22.6 burn yards per target.

For the season, Smith-Schuster now has a burn rate of 72.3 per cent, which is third among wide receivers with at least 25 targets.

In other words, he is creating separation at an elite level and, as he displayed versus the 49ers, he is doing so regardless of the coverage he is facing.

Smith-Schuster was outstanding in Week 7 when attacking both man and zone coverage.

Against man, he used his physicality and his 215-pound frame to win his matchups with the 49ers' cornerbacks.

He ran a pivot route on third down and relied on his superior bulk to get free of Deommodore Lenoir and convert with a five-yard gain to set up the Chiefs' first touchdown to Mecole Hardman.

Smith-Schuster then converted on second down on a six-yard slant, getting physical with former Chief Charvarius Ward to keep Kansas City out of a third down situation on a drive that ended with another touchdown for Hardman.

The former Pittsburgh Steeler ended the first half with a 19-yard reception on a back shoulder throw, which he brought in by easily beating backup corner Ambry Thomas at the catch point.

In the second half, though, Smith-Schuster thrived through his ability to exploit zone coverage.

The Chiefs proved near-unstoppable on third down, and Smith-Schuster came up with a key conversion on 3rd-and-2 that eventually culminated with a Mahomes strike to Justin Watson to put them up 28-16.

San Francisco rotated to a two-deep safety zone coverage at the snap, but it was they who were fooled by Mahomes, who never turned his eyes to Smith-Schuster until the last second, the Chiefs quarterback and a route by tight end Travis Kelce holding nickel defender Jimmie Ward and creating a big hole in the zone into which Smith-Schuster ran an out-breaking route.

Smith-Schuster broke his route to the outside at the perfect depth to ensure safety Tashaun Gipson had too much ground to make up, with Mahomes putting the ball high where only his receiver could get it as they connected for a 15-yard gain.

Mahomes was able to hold the defense with his eyes because of obvious faith Smith-Schuster would be in the right spot to make the play, and that confidence in the Chiefs' new top wideout will keep blossoming if he continues to make plays after the catch, on which he has racked up 210 yards so far this season -- 13th most in the NFL.

He did so on the drive that set up Hardman's third and final touchdown, Mahomes settling for a short throw to Smith-Schuster on an underneath crosser against the 49ers' Cover 6 look protecting the endzone. Smith-Schuster broke one-tackle and gained 20 yards to put the Chiefs on the three-yard line.

The final scoring drive was dominated by Smith-Schuster, who on a second-and-20 got the Chiefs in position to convert on third down, gaining more yards after the catch on a 14-yard completion from Mahomes on a stop route. Corner Charvarius Ward was again playing zone, but dropped deep to guard against a corner route from Hardman, giving Smith-Schuster an easy reception.

His defining contribution came on the next play on another routine catch that Smith-Schuster turned into a long touchdown, capitalising on a zone coverage bust to surge 47 yards into the endzone. Smith-Schuster was left alone to settle into a huge void in the middle of the field. That space should have been occupied by All-Pro linebacker Fred Warner, but he had vacated the area to cover Kelce, leaving Smith-Schuster free to cap a dominant day for the Chiefs' offense in style.

Hardman's three touchdowns and Mahomes' 423-yard day may have attracted more attention, but it is the astute acquisition of Smith-Schuster that is unlocking this latest version of Andy Reid's offense.

Smith-Schuster offers Mahomes a receiver who excels attacking zone coverage and who can consistently turn short throws into plays that wear down a defense even when it has succeeded in forcing him to take the underneath option through the use of the two-high zones that have become the default reply to the Chiefs' attack.

Despite not having top-end speed, Smith-Schuster can critically also win against man when defenses take a more aggressive approach to the persistently infuriating challenge of trying to stop Mahomes. He could scarcely be a more different receiver to what Mahomes had when Hill was his number one wideout, but Smith-Schuster's skill set is one that gives the Chiefs answers to the variety of tests defenses are throwing at them.

And, as the burgeoning chemistry between Mahomes and Smith-Schuster grows, it will once again be defenses who are left desperately searching for a solution.

The Kansas City Chiefs' offense fired on all cylinders against a vaunted San Francisco 49ers defense on Sunday, and Juju Smith-Schuster had an interesting explanation for their success.

Kansas City recovered from an early 10-0 hole to prevail in Week 7, the Chiefs exploding and pulling away in the fourth quarter in a 44-23 triumph.

Quarterback Patrick Mahomes shredded the Niners for 423 yards and three touchdowns, bouncing back in emphatic fashion after his interception on the Chiefs' first drive set up San Francisco's opening touchdown.

Smith-Schuster and Marquez Valdes-Scantling both went over 100 yards receiving and tight end Travis Kelce had 98, while Mecole Hardman found the endzone three times, twice as a rusher and once as a receiver.

San Francisco entered the game as the NFL's top defense, allowing only 255.8 yards per game, and the Chiefs were coming off a Week 6 game in which they were frustrated and held to 20 points in a loss to the Buffalo Bills.

But instead of those point-scoring issues carrying into another tough matchup, the Chiefs found the explosiveness they needed, with Smith-Schuster crediting an online gaming session between Mahomes and his pass-catchers for their devastating display.

"I'm gonna tell you what got us the chemistry when we needed this game," Smith-Schuster told a press conference. 

"So, I think it was Friday night. It was me, Pat, Travis and MVS. We were playing Call of Duty together, we were playing Warzone, and we played three games, and we won three games, back-to-back.

"We got off, and we were like, 'damn'. It's really hard to win a game in Warzone. 

"You could just... the communication between all of us, and then the chemistry? It was like we were in the game. It kind of just led into this game, and it kind of just showed on the field."

Christian McCaffrey was disappointed to suffer defeat on his San Francisco 49ers debut after a "weird week", but wants to focus on what he can control.

McCaffrey only joined the 49ers at the end of last week in a trade from the Carolina Panthers, and was thrown straight into the action against the Kansas City Chiefs on Sunday.

The Chiefs ran out 44-23 winners at Levi's Stadium, with McCaffrey only involved in 21 snaps, making 38 yards from eight carries.

The 26-year-old All-Pro was clearly still getting used to the idea of swapping Carolina for San Francisco, but said after the game he wants to get up to speed quickly.

"This was a weird week for me and for [the team]," he told reporters. "I didn't know what to expect. I know I had a certain list of plays that were up.

"For me, mentally, this was just 'focus on everything I can control and get rolling'. Obviously losing's frustrating, but I'm still getting to know these guys, I gotta do my job, I gotta make a few more plays here and just learn the offense as quick as possible.

"I'm just trying to control what I can control right now and get going."

The Niners are 3-4, having lost their last two games, and tight end George Kittle warned that McCaffrey cannot be expected to "be the saviour".

"He's not going to be the saviour, but he's definitely going to help us out," Kittle said. "I think these next two weeks are going to be huge for Christian to understand our offense and be comfortable out there not to think at all, just go out and run because that's what he's really good at.

"Like I said, penalties, turnovers, giving up big plays on defense, we've got to be better than that. We weren't today. That's how you lose football games."

The Kansas City Chiefs are the highest scoring team in the NFL through Week 7 after a convincing 44-23 road win against the San Francisco 49ers on Sunday.

San Francisco were in the headlines this week after pulling the trigger on a big trade for superstar running back Christian McCaffrey, but it was Chiefs quarterback Patrick Mahomes controlling the contest.

Mahomes threw an interception on the Chiefs' first drive, but turned things around quickly and ended up completing 25 of his 34 passes for 423 yards and three touchdowns.

He tossed second-half touchdown passes to Justin Watson and JuJu Smith-Schuster, and his first touchdown pass to Mecole Hardman was the beginning of a memorable day for the speedy receiver.

After getting on the end of an eight-yard score from Mahomes in the first quarter, Hardman then took a jet-sweep 25 yards down the sideline in the second quarter for the first rushing touchdown of his career. 

Not done yet, Hardman added his second rushing touchdown and third overall score for the game with a three-yard run in the fourth period. He finished with two carries for 28 yards and two rushing TDs, with four catches for 32 yards and a receiving TD.

For the 49ers, Jimmy Garropolo was not to blame for the loss as he finished 25-of-37 for 303 yards, two touchdowns and an interception – with touchdown passes to George Kittle and Ray-Ray McCloud III.

McCaffrey carried the ball eight times for 38 yards, and caught both of his targets for 24 yards through the air.

Seahawks move above .500 with upset in Los Angeles

The Seattle Seahawks rode a spectacular performance from rookie running back Kenneth Walker III to a 37-23 upset win on the road against the Los Angeles Chargers.

Walker rushed 23 times for 168 yards and two touchdowns, capped by a 74-yard rushing touchdown in the fourth quarter to put the game to bed.

Seahawks quarterback Geno Smith was solid, completing 20-of-27 passes for 210 yards and a pair of touchdown passes to Marquise Goodwin as he assumed a major role following a knee injury to key wide receiver D.K. Metcalf.

Chargers star Austin Ekeler remains the top running back in fantasy football, rushing for 31 yards and a touchdown, as well as catching all 12 of his targets for 96 yards and a second score.

Christian McCaffrey is expected to make his debut for the San Francisco 49ers against the Kansas City Chiefs.

Former All-Pro running back McCaffrey was traded to the 49ers from the Carolina Panthers on Thursday for second, third and fourth-round picks in 2023 and a fifth-rounder in 2024.

The tight turnaround initially made it look unlikely McCaffrey would be overly involved in a rematch of Super Bowl LIV from the 2019 season.

However, according to ESPN's Adam Schefter, McCaffrey will play and the 49ers will have a package of plays ready for him.

The Chiefs will have a new lead runner in their backfield, with rookie Isaiah Pacheco set to get the bulk of the carries over 2020 first-round pick Clyde Edwards-Helaire.

Kansas City's closest rivals in the AFC West, the 4-2 Los Angeles Chargers, face NFC West opponents themselves in the form of the Seattle Seahawks.

They had hoped to have wide receiver Keenan Allen back from a hamstring injury that has kept him out since Week 1, but his status was still up in the air heading into Sunday.

Star Seahawks wideout Tyler Lockett is set to play having been listed as questionable with a hamstring injury of his own.

The Baltimore Ravens, another prospective AFC contender, have been boosted with tight end Mark Andrews (ankle) and Rashod Bateman (knee) both active for their meeting with the Cleveland Browns. 

The Dallas Cowboys will not have to defend D'Andre Swift in Dak Prescott's return to action. Detroit Lions running back Swift is once again inactive because of ankle and shoulder injuries.

Detroit's division rivals the Green Bay Packers are looking to end a two-game losing run and get their offense back on track against the Washington Commanders.

Yet they will be without oft-injured left tackle David Bakhtiari because of a flare-up in his knee. The Packers have remodelled a struggling offensive line, shifting Elgton Jenkins from right tackle to left guard. Yosh Nijman takes over at right tackle, with rookie Zac Tom filling in for Bakhtiari.

Wide receiver Sammy Watkins will return from a knee injury as Aaron Rodgers desperately searches for targets he can trust.

Not every NFL week is going to be filled with great games. The law of averages says there will be some clunkers.

But it only takes one game to spice up a Sunday, and Week 7 has such a contest in the form of a Super Bowl rematch.

The Kansas City Chiefs beat the San Francisco 49ers in Super Bowl LIV three seasons ago, the Niners failing to finish the job in Miami having led 20-10 with seven minutes remaining.

San Francisco's first chance for a measure of revenge comes on Sunday, when the 49ers host the Chiefs in a game SmartRatings sees as the best of the week.

SmartRatings is a Stats Perform AI-based platform that provides excitement ratings for sporting events, teams and players. The excitement scale, ranging from 0-100, is powered by complex algorithms that are predicated upon six primary variables: pace, parity, novelty, momentum, context and social buzz.

The weight of each variable is dynamic and adapts as a season progresses. The excitement scale translates to the following general sub-ranges: 0-39 (Dull Game), 40-64 (OK Game), 65-84 (Good Game), 85-100 (Great Game).

Here, we take a look at Chiefs-49ers clash in the Bay Area and two other games viewed as the most exciting of Week 7 and the key matchups that could decide them.

Green Bay Packers @ Washington Commanders

SmartRating: 54

Win Probability: Packers 74.2%

Key Matchup: Allen Lazard vs. Washington cornerbacks

Randall Cobb's injury means Aaron Rodgers has even fewer receivers he can trust, so Lazard can expect plenty of targets to come his way as the Packers look to end a two-game losing run.

The numbers suggest Lazard will be able to find joy against a vulnerable Washington secondary.

Lazard has won his matchup with a defender, which Stats Perform labels as a 'burn', on 21 of his 32 targets. His burn rate of 65.6 per cent is above the league average of 60.6 for receivers with a minimum of 20 targets.

He has produced a big play on 12 of those targets, good for a big play rate of 37.2 that is 10th among wideouts (min. 20 targets).

Washington's starting corners, Benjamin St. Juste and Kendall Fuller, have allowed 12.27 and 13.15 burn yards per target respectively -- the average for corners with at least 20 targets is 10.05.

Both have given up a big play on over 30 per cent of their targets -- St. Juste (31.3%), Fuller (36%) -- at a position where the average is 25.5. In other words, Rodgers and Lazard should theoretically be able to thrive against both starting corners. If they do, the Packers' passing game might finally get on track and boost Green Bay's hopes of a deep playoff push many anticipated before their underwhelming start.

Indianapolis Colts @ Tennessee Titans

SmartRating: 60

Win Probability: Colts 54.4%

Key Matchup: Jeffery Simmons vs. Quenton Nelson

The AFC South is turning into a dogfight, with the 3-2 Titans leading the 3-2-1 Colts by half a game going into this divisional clash.

For the Colts to make sure the tie with the Houston Texans that separates them and the Titans does not prove costly down the stretch, they need to knock off Tennessee.

Doing that will involve stopping Jeffery Simmons, who has been a force on the interior of the Tennessee defense.

Simmons has beaten a pass protector on 18 of his 23 pressures this season. Only four interior defensive linemen have defeated a blocker on a pressure more often.

However, the Colts have a left guard in Quenton Nelson who has once again been one of the NFL's elite at his position in 2022.

Nelson has allowed a pressure on just 3.1 per cent of his pass protection snaps, giving him the sixth-best pressure rate among guards with at least 100 snaps this season.

The Colts will at least need to slow down Simmons for their passing game to prosper as it did against the Jacksonville Jaguars, and the heavyweight battle between two former first-round picks in the heart of the trenches could well decide who takes command of the division.

Kansas City Chiefs @ San Francisco 49ers

SmartRating: 71

Win Probability: Chiefs 50.7

Key Matchup: Fred Warner vs. Chiefs offense

A Super Bowl rematch between two teams coming off losses was made spicier with the news of San Francisco's blockbuster trade for running back Christian McCaffrey on Thursday.

But McCaffrey is unlikely to have much of an impact if he does play on Sunday given the limited time he has had to absorb the 49er playbook.

More key to the 49ers' hopes of at least partially avenging their Super Bowl collapse is the performance of a player who intercepted Mahomes in that game, Fred Warner.

The 2020 first-team All-Pro is the organisational heartbeat of the 49er defense, the man who plays a pivotal role in ensuring DeMeco Ryans' group is ultra-disciplined and consistently in the right position to make plays.

That discipline fell down in Week 6 defeat to the Atlanta Falcons, in which an extremely banged-up defense struggled to handle the Falcons' array of motions and zone-read runs involving quarterback Marcus Mariota.

San Francisco will get back a host of players from injury this weekend and the defense must do a better job of handling motion against an offense that heavily relies on it and will have to be alert to Mahomes' running threat, which for defenses is a frustrating complement to the wondrous things he can do throwing the ball.

Still, with no Tyreek Hill, the Chiefs' avenues to explosive plays are not as plentiful as they once were, and the 49ers will likely approach Kansas City in a similar way to the Buffalo Bills defense last week, leaning on two-high safety zone coverages in an attempt to force Mahomes to attack underneath.

Warner has allowed receivers to get open in zone coverage on just 10.87 per cent of his zone plays, his zone open rate the best in the NFL among linebackers. With his acumen in that area of the game and the athleticism he possesses to run downfield with Mahomes' primary target Travis Kelce, a bounce-back effort from Warner will be crucial to San Francisco's hopes of overturning odds that are slightly in Kansas City's favour.

Heading into Week 7 of the NFL season, the picture is still delicately poised as the race for the playoffs begins to heat up.

The Philadelphia Eagles (6-0), Buffalo Bills (5-1) and Minnesota Vikings (5-1) are all on a bye this week, along with the Los Angeles Rams (3-3), which provides an opportunity for the chasing pack to close the gap.

Both New York franchises are on the road as they look to extend their winning records, the Giants in Jacksonville to face the Jaguars while the Jets tussle with the Denver Broncos, and elsewhere, the Kansas City Chiefs have a stern test in San Francisco against the 49ers.

With all that and more on the cards, Stats Perform has delved into the numbers to preview this weekend's action.

New York Giants (5-1) @ Jacksonville Jaguars (2-4)

The Giants may have season form on their side against the Jaguars but they are the only team to never win a road game in Jacksonville (0-3), who are one of two franchises the Giants have not won against away from home alongside the Baltimore Ravens.

Victory against the Ravens in Week 6, coming on home soil, saw the Giants secure a fifth win of the season and become the first NFL team this term to surpass their win total from last year (four). Their largest wins increase in the Super Bowl era was from one in 1966 to seven in 1967.

Daniel Jones' form has been key to that improvement, completing at least 70 per cent of his passes in back-to-back games for the first time in his career. He has the opportunity to become only the second Giants QB in the Super Bowl era to do so in three straight games, alongside Eli Manning in September 2018 (minimum 20 attempts each game).

The Jaguars' 2-4 record does not paint the full picture of their season, though, with a +24 point differential standing as the sixth best in the NFL and the best for a team with a losing record through six games since the 2010 Los Angelese Chargers (+31, 2-4).

In last week's defeat to the Indianapolis Colts, Trevor Lawrence completed 20 of 22 passes (90.9 per cent) to become the youngest player (23 years, 10 days) to ever record 90 per cent accuracy from at least 20 passing attempts in a game.

Kansas City Chiefs (4-2) @ San Francisco 49ers (3-3)

Kansas City face the 49ers boasting victories in four of the last five matchups, including a 31-20 triumph in Super Bowl LIV, but are 1-5 in San Francisco – with their only win there coming in the teams' first-ever clash in 1971.

The Chiefs have not been strong defensively, allowing at least 20 points in all six games to begin the season and stand as one of four teams who are yet to allow fewer than 20 in any game this season.

That bodes well for the 49ers, who are 2-0 at home this season and have allowed fewer than 10 points in both of those games, though they have never held their opponent to fewer than 10 points in the team's first three home games of any season.

The potential return of Nick Bosa will be of concern for Patrick Mahomes, after he missed last week due to a groin injury, as the 49ers are pressuring quarterbacks in 48.4 per cent of passing plays with Bosa on the field (122 plays) compared to 34.9 per cent without him (86 plays).

New York Jets (4-2) @ Denver Broncos (2-4)

The Denver Broncos are in need of a major improvement in performance and hosting the Jets will provide encouragement, having shut them out in two straight home games, including 26-0 last year.

The Jets have reason to be optimistic themselves, however, with last week's 27-10 victory against the Green Bay Packers securing their first three-game winning streak since 2019 and their first three-game road winning streak in a single season since 2010.

Meanwhile, the Broncos fell to a 19-16 overtime defeat to the Chargers in Week 6 and suffered their second straight overtime loss, with no team ever having played three straight overtime games in NFL history.

Russell Wilson found himself under scrutiny again last week, completing only 15 of his 28 pass attempts for a completion percentage of 53.6. In total this season, he has a 58.6 completion percentage, having entered the year with a lowest single-season completion percentage of 61.3 in 2017.

Elsewhere…

The Pittsburgh Steelers lost their first six road games as a franchise against the Miami Dolphins but head to Florida in Week 7 with a 6-3 record in the past nine meetings. However, they have not had a quarterback start at the Dolphins other than Ben Roethlisberger since Kordell Stewart in 1998.

Each of the last 11 games between the Seattle Seahawks and the Chargers have been decided by a single-digit margin, with the only longer streak in NFL history being a 14-game stretch between the Colts and Houston Texans from 2014 to 2020.

Aaron Rodgers stands 0-3 in road games against the Washington Commanders, with the Green Bay Packers 2-8 in their last 10 games in Washington – their victories coming in 1968 and 2004.

Tom Brady faces the Carolina Panthers with 15 completions in each of his last 39 games for the Tampa Bay Buccaneers, tying Brady's career-best streak with 39 straight games for the New England Patriots from 2011 to 2013.

Last season, the Buffalo Bills looked to have cracked the code of how to topple the Kansas City Chiefs.

The Bills beat the Chiefs 38-20 in Arrowhead Stadium in Week 5 of 2021, averaging 8.1 yards per play to Kansas City's 5.0, frustrating Patrick Mahomes and intercepting him twice in a display that suggested the balance of power in the AFC was about to shift.

Yet it proved a false dawn, with the Bills unable to contain Mahomes in the Divisional Round of the playoffs and famously failing to prevent him leading the Chiefs down the field in 13 seconds for a game-tying field goal that forced overtime in arguably the finest playoff game in NFL history.

While that game confirmed Josh Allen as existing on Mahomes' level among the NFL elite at quarterback, throwing for 329 yards and four touchdowns, it also was an irritating illustration of the Bills' lack of closers on defense.

The Bills pressured Mahomes 23 times but managed to sack him just twice, a dreadful conversion rate that prompted Buffalo to hand a six-year, $133million contract to 33-year-old edge rusher Von Miller.

Though Buffalo can get out of the contract much earlier, the length of the deal handed to Miller raised eyebrows, with the Bills making a substantial bet on the veteran who played a critical role in the Los Angeles Rams' Super Bowl run following his mid-season trade from the Denver Broncos maintaining the level that helped him claim a second ring.

Few are likely to be questioning his deal in the wake of his performance on Sunday, however, as 371 days on from their win at Arrowhead last season, Miller helped the Bills repeat the feat, recording two sacks in a Buffalo performance that will substantially boost hope they have a formula to defeat Kansas City in the postseason.

On offense, the Bills leaned on one of the most devastating quarterback-wide receiver connections in the NFL. 

Allen targeted Stefon Diggs 13 times in the Bills' 24-20 win, hooking up with the former Minnesota Viking on 10 occasions as Diggs finished with 148 receiving yards and a touchdown.

Though not all of his targets resulted in a completion, Diggs delivered reinforcement, not that it was needed, of his status as one the game's top separation artists. He registered a burn, which is when a receiver wins his matchup on a play where he is targeted, on 12 of those 13 targets. Only the two receivers who posted 100 per cent burn rates, Tyler Boyd (six targets) and Juju Smith-Schuster (five) fared better than Diggs in that sense in Week 6 (min. five targets).

The volume Diggs receives as Allen's top target and the consistency he shows in creating separation makes for a frightening combination for defenses, and he proved too much for the Chiefs on the Bills' go-ahead drive, Allen finding Diggs for two first-down receptions, including one that set Buffalo up at the Kansas City 28-yard line.

With the Chiefs running a two-high safety zone coverage, Diggs displayed his route-running acumen by attacking the leverage of cornerback Jaylen Watson at the top of his downfield route to buy himself critical extra cushion as he settled in the soft spot in the zone before making a superb adjustment at the catch point.

Allen created extra time for himself by subtly shuffling to his left as Carlos Dunlap pushed the pocket, hanging in there and delivering a high-velocity ball that was further in front of Diggs than intended due to the interior rush from Chris Jones reducing his throwing platform. Diggs put his body on the line by laying out for the ball and survived the contact from Watson and safety Juan Thornhill.

Three plays later, after Allen had remarkably hurdled a defender on a 16-yard rush, he found Dawson Knox on a superbly accurate throw to the endzone to put the Bills ahead for good, the tight end deserving of great credit for the manner in which he worked his way back to the ball at the end of his corner route.

That drive came after Miller had forced the Chiefs off the field with a third-down sack of Mahomes, showcasing his still impressive physical flexibility and his motor to work his way around the corner and past right tackle Andrew Wylie to bring down the quarterback.

And Miller played a critical role in the game-clinching interception that followed on the subsequent drive.

Given Mahomes' exploits in last year's playoff matchup, 64 seconds appeared to be plenty of time for him to drive the Chiefs down the field for a game-winning touchdown following Knox's score. 

Miller, though, provided the finishing touch the Bills lacked in the postseason, winning inside with his lateral quickness to get pressure through the B gap, forcing Mahomes into a late throw to Skyy Moore on a crossing route that corner Taron Johnson read all the way, breaking down from his position in the Bills' zone coverage to intercept the pass and end the game.

While the Bills only improved their sack total from the Divisional Round shoot-out by one, Miller's ability to frequently dominate his pass rush matchups at this point in his career had a direct influence on Buffalo knocking off their biggest challenger for the one seed in the AFC and the team most expect them to meet again in the conference title game.

The rapport between Allen and Diggs and the big-play production of Gabe Davis – who followed up his stunning two touchdown-effort against the Pittsburgh Steelers with a 34-yard touchdown reception and leads the league in burn yards per target among receivers with at least 20 targets (16.98) – should ensure the Bills will continue to boast an explosive passing game few in the NFL can rival.

If Miller can supplement that by serving as the closer on a defense that has Pro Bowl talent at every level, the Bills may finally have the recipe to land the knockout blow against the Chiefs when it matters most.