A host of teams can start 2023 on a high note by clinching an NFL playoff place in an eagerly awaited Week 17.
There are also divisional titles to be won on New Year's Day, with Tom Brady's Tampa Bay Buccaneers within touching distance of winning the NFC South ahead of a clash against the Carolina Panthers.
The Seattle Seahawks and the New York Jets lock horns scenting a spot in the postseason, while the Miami Dolphins could seal a playoff berth when they do battle with the New England Patriots.
Here Stats Perform used its data to preview the biggest games with plenty at stake at the beginning of a new year.
SUNDAY (all times EST)
Panthers (6-9) at Buccaneers (7-8) 1pm
The Buccaneers can clinch the NFC South title for a second straight season if they beat the Panthers, a feat they have never previously achieved.
After a 21-3 win in Week 7, the Panthers are going for the season sweep of the Buccaneers for the first time since 2017. That was also the last season they made the playoffs.
Tampa Bay beat the Arizona Cardinals 19-16 in their final game of 2022. The Buccaneers have scored 21 or fewer points in all seven of their wins this season.
Carolina overcame the Detroit Lions 37-23 in Week 16 behind 320 yards rushing and 250 yards passing. They were the first NFL team with 300 rush yards and 250 pass yards in a game since the San Francisco 49ers in Week 12, 2012.
Jets (7-8) at Seahawks (7-8) 4.05pm
The Seahawks have dominated the Jets in recent years, winning all four games against them since 2005 and conceding only 30 points in the process. That is just 7.5 points per game, which is the fewest allowed by any NFL team against a single opponent over that time.
Pete Carroll is in his 17th season as an NFL head coach and has never missed the playoffs in consecutive seasons. The Seattle boss is the only head coach in NFL history to coach at least 15 seasons in the league and never have consecutive seasons in which he did not lead his team to the playoffs.
DK Metcalf has had at least five receptions in eight straight games, tied with John L. Williams (1989-90) and Brian Blades (1995) for the longest streak in Seahawks franchise history.
The Jets are allowing 10.8 fewer points per game than they did last season (29.6 to 18.8), on pace to be the second-largest season-to-season improvement in the NFL in the past 40 years behind the 2000-01 Rams (29.4 to 17.1, -12.3).
Dolphins (8-7) @ Patriots (7-8) - 1pm
New England are due a win over the Dolphins, who have beaten them in four consecutive games - the last of which was a 20-7 success in Week 1.
Miami are the only team to beat the Patriots four times in a row since Bill Belichick took over as head coach of the Patriots in 2000. With a loss this week, Miami would join Tennessee as the only teams this season with a winning streak of at least five games and a losing streak of at least five games.
Tua Tagovailoa posted a career-high 12.4 yards per pass attempt in last week's loss to the Green Bay Packers. It was the highest yards-per-attempt in a loss by a starting Dolphins quarterback in team history. He misses out this week due to concussion, though, so Teddy Bridgewater steps in.
New England’s comeback bid fell short in a 22-18 loss to the Bengals last week. The Patriots have lost nine straight games when trailing after three quarters, with only the Panthers (41 straight losses) and Seahawks (13 straight) having longer active streaks.
MONDAY
Bills (12-3) @ Bengals (11-4) - 8.30pm
The Bills know they will get a first-round bye in the playoffs if they see off the Bengals and the Kansas City Chiefs lose to the Denver Broncos. Following Cincinnati's win over the Bills in the 1988 AFC Championship Game, the Bills won 10 straight in this series. Since then, Cincinnati are 4-2 against Buffalo, with the most recent meeting resulting in a 21-17 Buffalo win in Week 3, 2019.
The Bills beat the Bears 35-13 in Chicago last week, extending their winning run to six games. Buffalo have scored at least 20 points in each of those wins – they have just two longer streaks of wins with 20+ points – a nine-game streak in 1964 and a seven-game streak in 1990.
The Bengals' road win over the Patriots extended their winning streak to seven games, one shy of tying the franchise record of eight – achieved in the first eight games of the 2015 season (also an eight-game streak spanning the 1970 and 1971 seasons).
Joe Burrow had 375 passing yards last week, his second-highest total of the season. It was his seventh career game with at least 350 passing yards, fourth most in the NFL since 2020 behind Tom Brady (13), Patrick Mahomes (12) and Josh Allen (9).
Elsewhere...
The Denver Broncos start life after Nathaniel Hackett with a tough trip to take on the Kansas City Chiefs in their first game since the head coach's firing. The Chiefs have won 14 straight games against the Broncos dating back to the 2015 season. Just five teams in NFL history have beaten another team 15 times in a row, with the last team to do so being the Patriots against the Bills from 2003 to 2010.
The Philadelphia Eagles host the New Orleans Saints knowing they can clinch the NFC East and the number one seed in their conference with a win.
The Eagles are 11-3 (.786) all-time at home against the Saints, which includes an active three-game winning streak. That is the Eagles' third-best home record against any opponent all-time (3-0 versus the Texans and 6-1 versus the Broncos).
A playoff place is in the New York Giants' sights as they prepare to take on the Indianapolis Colts.
The Colts have won four straight games against the Giants, with the most recent win coming in Week 16 of 2018 with a 28-27 home victory.
There appears to be no stopping the San Francisco 49ers, who can win a ninth game in a row when they take on the Las Vegas Raiders. The 49ers are the only NFL team in the Super Bowl era to win eight straight games in a single season while holding their opponents to fewer than 80 rushing yards in each victory.