Patrick Mahomes threw two touchdown passes but Missouri rookie Nick Bolton came up with the key play as the Kansas City Chiefs kept their AFC top seeding hopes alive with a seesawing 28-24 win over the Denver Broncos.

Bolton delivered a 86-yard scoop and score to give the Chiefs a lead they would not relinquish in the fourth quarter after Melvin Ingram's tackle forced a fumble from Broncos running back Melvin Gordon.

The result means the Chiefs (12-5) will claim the AFC top seed if the Tennessee Titans (11-5) fail to beat the Houston Texans on Sunday.

The victory was also the Chiefs's 13th straight road win against AFC West opponents.

Mahomes completed 27 of 44 passes for 270 yards with two TD passes for Travis Kelce in the first quarter and Jerick McKinnon in the third. The Kansas City QB also rushed 54 yards from nine carries.

The Broncos, who will finish last in the AFC West with a 7-10 record, were difficult to shake all game, with QB Drew Lock rushing two touchdowns, while running back Gordon scored a 47-yard TD to put them up 20-17 in the third.

The Chiefs found the match-winning play in the fourth quarter as the Broncos closed the nine-yard line after a 10-play drive with Ingram forcing the error and Lock unable to tackle Bolton.

The 18th and final round of the NFL regular season is upon us and there remains plenty of intrigue in a frantic scramble to make it to the playoffs.

Five teams from the AFC are competing for two postseason berths, while one spot is up for grabs in the NFC. 

Away from the Super Bowl picture, there are a number of other intriguing subplots ahead of an action-packed weekend.

Stats Perform previews some of the standout games and the best of the rest.

Los Angeles Chargers (9-7) @ Las Vegas Raiders (9-7)

The winner of this contest is guaranteed a playoff spot, while there is also a scenario whereby a tie could see both advance. Interestingly, six of the previous seven games in Oakland/Las Vegas have been decided by three points or fewer.

The Raiders beat the Colts on a last-second field goal last week to prevail 23-20 – their fifth win of the season by four points or fewer, tied with the Packers and the Titans for the most in the NFL.

Justin Herbert set the single-season passing touchdowns record for the Chargers last week with his 35th of the campaign. He now requires 172 yards this week to also take the passing-yards record.

The Chargers' 34-13 win against the Broncos was their fourth victory in a win while scoring 30 points or more. They have averaged 33.9 points per game in wins this season, second most in the NFL behind the Bills (35.1).

Pittsburgh Steelers (8-7-1) @ Baltimore Ravens (8-8)

The Steelers have won three in a row against the Ravens, with all three of those victories being decided by less than a touchdown, the most recent coming by a 20-19 scoreline last month.

Last week's 12-point win over the Browns was the Steelers' largest of the season, though not since 1969 have they gone a full campaign without winning by at least 13 points.

The Ravens are coming off the back of a 20-19 loss to the Rams, their league-leading eighth game decided by three or fewer points this season – no team in NFL history has had more than nine games decided by three or fewer points.

Najee Harris rushed for 188 of the Steelers' 190 rushing yards against the Browns and accounts for 77.9 per cent of his side's rush yards this season, the highest share of any player in the NFL.

Kansas City Chiefs (11-5) @ Denver Broncos (7-9)

The Chiefs will be looking to respond to their defeat against the Cincinnati Bengals in week 17 when they take on the Broncos, whom they have defeated in 12 successive meetings – the league's joint-longest active winning streak along with the New England Patriots against the New York Jets.

Despite last week's defeat, the Chiefs have scored at least 30 points in four successive games, which is the longest-running streak in the NFL and one short of their all-time record of five set in 2004 and 2018.

Kansas lead the way in the NFL with 391 first downs this season and, with nine more this weekend, will become the fifth team in the last 70 years with 400 or more first downs in a season.

The Broncos were defeated by the Chargers last time out to ensure a losing season for the fifth straight year, an unwanted run they last went on from 1963 to 1972 with 10 straight losing seasons.

The Jaguars require a victory against the Colts to avoid becoming the fourth team in the last 30 years to have consecutive seasons with two or fewer wins. The Colts have lost three games this season by exactly three points – the Seahawks are the only team this season that has failed to win a single game by three or fewer points with more losses in such games (0-5).

The Rams can clinch their third NFC West title in six seasons season since moving back to Los Angeles with victory over the 49ers. However, the Niners have won each of their last five meetings with the Rams.

The Falcons have three successive wins against the Saints in Atlanta and are seeking a fourth in a row for the first time since between 1991 and 1994. Following defeat to the Bills last week, the Falcons have alternated between wins and losses over their last seven games.

The Bills can clinch their second consecutive division title with victory against the Jets, following on from a previous run of 24 straight seasons without finishing top. All 10 of Buffalo's wins this season have come by 12 points or more.

The Arizona Cardinals continued their excellent road form as they edged the Dallas Cowboys 25-22 in a potential-playoff preview with Kyler Murray leading the way on Sunday.

The Cardinals improved their season record to 11-5 and their road record to 8-1, snapping a three-game skid, with Texas-born Murray throwing two touchdowns as he completed 26 of 38 attempts for 263 yards.

The Cowboys had trailed 22-7 at the final charge but stormed back into contention as Dak Prescott threw three TD passes for the game but Murray expertly managed the clock late.

Murray found Antoine Wesley for two TDs including a spectacular catch in the third quarter, while Jonathan Ward made a remarkable helmet catch on a fake punt.

The Cowboys lost Michael Gallup to injury upon his second-quarter receiving touchdown and did not return, not helping their cause.

Prescott, who completed 24 of 38 passes for 226 yards along with 20 rushing yards, found Cedrick Wilson and Amari Cooper for final-quarter TDs to tighten the game but he also had a costly fumble at 22-14.

Chargers snap skid as Williams scores 101-yard return

The Los Angeles Chargers snapped a two-game skid with a 34-13 victory over the Denver Broncos to boost their Wild Card hopes as they improve to a 9-7 record.

Chargers quarterback Justin Herbert threw 22 of 31 passes for 237 yards with two touchdowns, breaking the franchise record for single-season touchdown passes at 35.

Andre Williams scored a 101-yard kickoff return touchdown in the fourth quarter, while Austin Ekeler returned to LA's line-up and was important, with 17 carries for 58 yards and a touchdown, along with three receptions for 54 yards.

Lance leads 49ers to key win in Wild Card race

Trey Lance stepped in for the injured Jimmy Garoppolo and provided two touchdown passes as the San Francisco 49ers won 23-7 over the Houston Texans.

Lance completed 16 of 23 passes for 249 yards with the two TDs and an interception to help the 49ers improve to 9-7 in the NFC Wild Card pursuit.

Deebo Samuel and Elijah Mitchell scored the touchdowns as the 49ers scored 20 second-half points to secure the win.

The Los Angeles Chargers' ability to challenge for the NFC West will be put to the test when they take on the Cincinnati Bengals in Week 13. 

Los Angeles have won three straight games since a defeat to the NFC-leading Arizona Cardinals and can ill afford a slip-up against a Bengals side that are challenging in the AFC North. 

The Kansas City Chiefs have finally hit their stride but face a tough test when the Denver Broncos visit Arrowhead Stadium, while Monday sees a battle for supremacy in the AFC East between the New England Patriots and the Buffalo Bills. 

We've run down some of the standout stats from the biggest games in Week 13. 

Los Angeles Chargers (6-5) @ Cincinnati Bengals (7-4) 

The Bengals will be hopeful of avenging their 16-13 loss to the Chargers in Week 1 – their second straight defeat to Los Angeles. However, Cincinnati won their four other meetings since the 2010 season and are riding high after a resounding 41-10 victory over the Pittsburgh Steelers last time out. 

It was only the third time the Bengals beat the Steelers by 30 points or more, with the last occurrence being all the way back in September 1989. 

An early kick-off on the east coast will be tough for the Chargers to navigate, particularly after a 28-13 loss to the Denver Broncos in Week 12. They had three rushing first downs against the Broncos, making it the fourth game in which they have had that many or fewer this season – the third most in the NFL. 

They may continue to rely on quarterback Justin Herbert to help them get points on the board. His 438 passing attempts this season places him third in the NFL, behind only Tom Brady (457) and Patrick Mahomes (449). 

The Chargers defense will need to keep a close watch on Joe Mixon, though. The running back had a career-high 165 rushing yards and 11 first downs in Week 12. 

Denver Broncos (6-5) at Kansas City Chiefs (7-4)  

Not only have the Chiefs won four straight after a 3-4 start, but they've also come out on top in 11 straight meetings with the Broncos – a run that stretches back to Week 10 of 2015. One more victory will make it the longest winning streak against a single opponent in the team's history. 

The game will have big implications on the playoff hopes of both sides, while the Broncos could move off the bottom of the AFC West and replace the Chiefs at the summit with a victory. 

Kansas City will hope Mahomes can restore the levels of production seen previously. He did not have a rushing or throwing touchdown in the 19-9 win over the Dallas Cowboys last time out, his second such game in his past five outings. In the 51 games before this run, he had a TD in 50 of them. 

He has still led an offense that has had 30 drives with 10 or more plays this season – the most in the NFL. Though the Chiefs' ability to get the ball out of their opponents' hands (they have allowed the fifth fewest drives with 10 or more plays this season) could be counteracted by Teddy Bridgewater's excellence under pressure. 

Bridgewater has a league-best completion percentage (77.6) to go with seven TD passes and no interceptions when facing the blitz this season. 

New England Patriots (8-4) at Buffalo Bills (7-4) 

The Bills dethroned the Pats in the AFC East in 2020 and could do with a home win to boost their chances of retaining the crown this year. 

New England fell to a 24-21 loss to the Bills on their last trip to Buffalo but are 15-2 across their previous 17 visits. They are also head into Monday's matchup on the back of a six-game winning streak. 

The game appears set to be played in frigid conditions and some stingy defenses may make for tepid action too – the Bills (182) and Patriots (190) are ranked first and second respectively for fewest points allowed this season. The Bills have allowed just 182 points while the Patriots have given up 190. 

Mac Jones threw for a career-high 310 yards in last week's win against the Tennessee Titans, but Buffalo made it 21 straight games in which they have had at least 300 yards of offense when the defeated the New Orleans Saints 31-6 on Thanksgiving. 

Stefon Diggs has been key for the Bills. He had 74 receiving yards against the Saints – his ninth game with at least 60 this season, behind only Cooper Kupp (11) and Justin Jefferson (10). 

Elsewhere... 

The Cardinals (9-2) are up against the Chicago Bears (4-7) at Soldier Field on their return from their bye week. The road team has won each of the last five meetings between these teams dating back to Chicago’s 20-point comeback on Monday Night Football in Arizona in Week 6, 2006. 

The New York Giants (4-7) will be hoping to stop the Miami Dolphins (5-7) make it five wins on the bounce. The Dolphins are the only team in the NFL this season to have had both a four-game winning streak and a four-game losing streak. 

Tom Brady leads the league in passing attempts (457), completions (309) and touchdowns (30) this season and will be hoping to steer the Tampa Bay Buccaneers (8-3) to victory at the Atlanta Falcons (5-6) 

The Seahawks (3-8) have lost eight games in a season for the first time since 2011, ending a franchise-record run of nine years with seven or fewer losses. However, they will no doubt be up for a grudge match against the San Francisco 49ers (6-5). 

The Baltimore Ravens tied the NFL record for most consecutive 100-yard rushing games after head coach John Harbaugh made a conscious decision to keep a "meaningful" streak alive.

With a 23-7 win over the Denver Broncos already in hand, the Ravens could have taken a knee in the final seconds but, three yards shy of tying the Pittsburgh Steelers' record of 43 successive games with at least 100 rushing yards, Baltimore elected to call a designed run for quarterback Lamar Jackson, who duly picked up five to keep their run intact.

Though moving to 3-1 on the season was of chief importance, Harbaugh felt the achievement of equaling the rushing record had a significance that influenced his decision.

"One hundred per cent my call," Harbaugh said. "That's one of those things that's meaningful.

"It's one of those things that, as a head coach, you've got to be mindful of your team and your players and your coaches and what it means to them.

"It's a very, very tough record to accomplish and it's a long-term record. I'm not going to say it's more important than winning the game, for sure. It's certainly not.

"But as a head coach, I think you do that for your players and you do that for your coaches and that's something they'll have for the rest of their lives."

Jackson, who threw for 316 yards and a touchdown, had a relatively quiet day on the ground, finishing with just 28 yards rushing.

Despite his coach's words, statistics and records clearly mean little to the 2019 MVP.

"I'm happy we got the [win]," Jackson said. "I'm not going to lie. I didn't even care about the record."

The Ravens can break the record next Monday when they host the 1-3 Indianapolis Colts in Week 5.