Madrid put its Formula One ambitions in writing on Thursday as Spanish capital chiefs declared the city is ready to host future races.
Enrique Lopez, minister of the presidency, justice and interior in Madrid, sent a letter to Formula One chief executive Stefano Domenicali in which he outlined the vision.
The Circuit de Barcelona-Catalunya has staged the Spanish Grand Prix since 1991, and the letter from Lopez did not explicitly state Madrid would seek to take over the hosting of that race.
The Barcelona circuit has a contract that runs until 2026.
In recent times, Valencia also staged the European Grand Prix from 2008 to 2012, while the Madrid region has not held a Formula One race since Gilles Villeneuve won in 1981 at the Circuito del Jarama.
Lopez pointed to Madrid's strengths in his approach to Domenicali, mentioning "an outstanding economic and social development in the Spanish and European contexts".
"I believe that holding in Madrid a motor racing event, which is one of the most exciting sporting phenomena of our time, would be a success for all the professionals, institutions and companies involved in the development of Formula 1. Of course, it would also be a satisfaction for the whole region and its citizens," Lopez wrote.
"That is why the government of the community of Madrid has the greatest interest in making it possible.
"In short, I would like to confirm our commitment to you and to this project, as well as our willingness to sign the appropriate agreements to promote the race and offer a great sporting and entertainment spectacle. We are ready to work with you and your team to bring Formula 1 to Madrid."
Serena Williams and Ons Jabeur have pulled out of their Eastbourne International doubles semi-final due to an injury concern just days before Wimbledon begins.
Organisers said Tunisian world number three singles star Jabeur was troubled by a right knee injury, forcing her brief alliance with Williams to come to an end.
They had won through two rounds in increasingly impressive style, with Williams making her return to the WTA Tour, having not played competitive tennis since injuring an ankle at Wimbledon last year.
The 40-year-old Williams was clearly enjoying the partnership with Jabeur, who in May became the first African or Arab woman to win a WTA 1000 singles title when she triumphed at the Madrid Open.
They had named themselves 'Onsrena' and were due to face Aleksandra Krunic and Magda Linette in the semi-finals, before news emerged on Thursday of their withdrawal.
No details of the seriousness of Jabeur's injury were disclosed, and it may prove a precautionary withdrawal given Wimbledon is so close, with the latter starting on Monday.
Jabeur won a title on grass in Berlin last week, showing she could pose a threat to top seed Iga Swiatek, providing she is not hampered by injury.
Williams, a 23-time grand slam singles champion, will also be competing at Wimbledon after being handed a wildcard entry into the tournament where she has won seven singles titles.
With the top three picks of the NBA Draft appearing to be Jabari Smith, Chet Holmgren and Paolo Banchero – likely in that order – the real fun begins with the Sacramento Kings at pick four.
The heavy favourite to be selected fourth overall is Purdue's Jaden Ivey, who projects as the top guard prospect in this year's class.
At 6ft 4in with tremendous athleticism, Ivey is a point guard that plays in a similar fashion to John Wall, although he is not the natural facilitator Wall is, leaning on his scoring and driving ability for his primary value.
Ivey was considered part of the top tier through early portions of the college basketball season until the three bigs elevated themselves further into their own conversation, but Ivey has been gaining so much steam throughout the pre-draft process that teams including the New York Knicks have reportedly been enquiring about trading up to the Kings' pick to select him.
Keegan Murray
After Ivey, the draft really opens up, although Iowa wing Keegan Murray will likely not fall outside of the top seven.
Murray is a 6ft 8in, highly skilled scorer who will be able to fill both forward spots in the NBA, and figures to be a player who will be able to create his own baskets in isolation situations.
He averaged 23.5 points and 8.7 rebounds per game during his sophomore season, and shot a terrific 55 per cent from the field and 39.8 per cent from three-point range on 4.7 attempts per game.
Defense is the question with Murray, but he has the size and athleticism to contribute on that end, while the team that drafts him will hope he can fill a similar role to Milwaukee Bucks All-Star Khris Middleton as a low-maintenance scorer who does not need to be the centrepiece of every play to stack up points, but can also take over if needed.
Shaedon Sharpe
The mystery man of this year's class is 6ft 5in wing Shaedon Sharpe, who did not play a single game this past season at the college level.
Sharpe was viewed as a potential top-five pick in next year's draft, but opted to expedite his process to turn professional as soon as possible, and he will be rewarded with a top-10 pick barring any unforeseen red flags.
Strongly built, athletic, long-armed wings with the ability to aggressively hit pull-up three-pointers and defend multiple positions are probably the most valuable archetype in the game right now, and Sharpe fits the billing.
With a game that resembles Paul George, Sharpe arguably has a ceiling as high as anybody in the class, but a lot of future NBA wings look like Paul George when their only footage is against high school kids.
Bennedict Mathurin
Arizona wing Bennedict Mathurin also appears to be a lock for the top 10 after a dominant March Madness run that included a 30-point outburst in an overtime win in the Sweet 16, profiling as a high-level traditional shooting guard.
Clearly a score-first player, Mathurin – 6ft 6in with a 6ft 9in wingspan – will be able to defend opposing ones, twos and threes while his well-rounded offensive game should comfortably translate to an off-ball role at the next level.
Through his two seasons at Arizona, Mathurin shot 38 per cent from three on five attempts per game, including difficult, contested looks, while he also showed he can score at all three levels, and even dished seven assists with his 27 points in a key tournament win.
Maybe the safest pick outside of the top three, Mathurin will comfortably score in the teens as a rookie if he lands in a situation with minutes available. Think of him as a more athletic C.J. McCollum.
Dyson Daniels
Arguably the most unique guard in the class is Australian Dyson Daniels, who played with the G-League Ignite, and he also seems unlikely to fall out of the top 10.
Daniels was viewed as a decent prospect as a 6ft 5in combo guard who specialised in defense and lacked a jump shot – then he grew another three inches, cleaned up his jump shot and began assuming point guard responsibilities.
At 6ft 8in now with guard skills and elite defensive upside, Daniels is perhaps the hardest player in the class to find an NBA comparison for. He is so unselfish and pass-first that his play style resembles pure point guards like Tyus Jones or Monte Morris, but he is at least six inches taller and can realistically guard four positions.
Unlikely to ever become a true first option, Daniels is best served playing next to a primary scorer, making him an ideal fit with Damian Lillard and the Portland Trail Blazers if they decide to use pick seven instead of trade it.
Ousmane Dieng
Speaking of late risers in the draft process, teams seem to be deciding that someone with the tools of France's Ousmane Dieng may have no business falling outside of the top 10.
Dieng, a massive wing measuring at 6ft 10in, showed some extremely interesting flashes of skill this past season as an 18-year-old playing with the New Zealand Breakers in the NBL.
Playing for a professional team, he was not given nearly the kind of leash as college prospects to show what they can do, averaging 15 minutes and three points through his first nine games.
But once he found his footing, it was clear he was a serious prospect, showing off sharp ball-handling and the ability to attack off the bounce in an 11-game stretch where he averaged 24 minutes and 14 points per game, scoring at least 17 points in five contests and shooting 20-of-56 from long range (35 per cent).
A.J. Griffin
The son of former NBA player and current Toronto Raptors assistant coach Adrian Griffin, the only thing that can force A.J. Griffin to slide down draft boards is his injury history.
With essentially the perfect body for an NBA wing at 6ft 6in and 220 pounds with a seven-foot wingspan, Griffin is yet to turn 19 years old, and shot a blistering 44 per cent from long range on 4.4 attempts per game in his sole collegiate season.
If he can stay healthy, Griffin will be a solid starting wing at the bare minimum, with similar offensive upside to Raptors forward O.G. Anunoby and the defensive tools to guard at least three positions.
Teams will take a look at his medicals and decide if he is worth the risk, with multiple serious injuries during his high school career and more injury concerns during his one year at Duke.
Scottie Scheffler has admitted it was "definitely a surprise" to see Brooks Koepka join the breakaway Saudi-backed LIV Golf series as he reaffirmed his commitment to the PGA Tour.
Koepka became the latest big name to join the controversial LIV series this week, following the likes of Bryson DeChambeau, Patrick Reed and Abraham Ancer to join after its maiden event in London earlier this month.
Those moving have faced significant backlash for their decisions, with Rory McIlroy questioning the approach of the players on Wednesday, and while Scheffler was surprised, he stopped short of direct criticism.
"It was definitely a surprise for me. I was at a function with him last week and that definitely wasn't what we had in mind," he told a news conference.
"We were focused on building the PGA Tour and getting the guys that are staying here together and kind of just having talks and figuring out how we can help benefit the Tour, so to see Brooks leave was definitely a surprise for us.
"With that being said, he's made his decision, I'm not going to knock him for doing that."
The world number one also reaffirmed his own commitment to the PGA Tour and rebuffed any chances of him following in Koepka's footsteps.
"For me, it's not where I see myself heading anytime soon. I grew up wanting to be on the PGA Tour.
"I grew up dreaming of playing in these events, I didn't grow up dreaming of playing the Centurion Club in London or whatever it is.
"I grew up wanting to play in the Masters, in Austin, at Colonial, the Byron Nelson.
"I wouldn't trade those memories for anything at this moment in time. Those memories to me are invaluable.
"I would never risk going and losing the opportunity to go back to Augusta every year.
"There's nothing I would want to do right now that would risk having any sort of effect on the way my life is now."
Shohei Ohtani’s dominance both on the mound and at the plate have become so commonplace that it has almost become a daily occurrence.
One night after he homered twice and drove in a career-high eight runs in a wild extra-inning loss, Ohtani struck out 13 over eight dominant innings in a 5-0 victory over the Kansas City Royals on Wednesday night.
On Tuesday, the reigning American League MVP set the single-game record for RBIs by a Japanese-born player when he hit a pair of three-run homers and added two sacrifice flies.
Not surprisingly, Ohtani is the first player in history to drive in at least eight runs and strike out at least 10 batters in consecutive games.
Tony Cloninger is the only other player to ever have eight RBIs and at least 10 strikeouts in a game in a season or a career. He accomplished the feat in 1966 for the Atlanta Braves, striking out 12 batters on April 12 and knocking in nine runs with two grand slams on July 3.
The Japanese sensation toyed with the Royals, allowing consecutive singles to Whit Merrifield and Andrew Benintendi to open the game before retiring 16 in a row – a stretch during which he struck out the side twice.
Ohtani set down 23 of the final 24 batters he faced, walked one and threw a season-high 108 pitches in matching the longest outing of his MLB career. He also singled and walked twice in his latest electrifying two-way performance.
The unprecedented talent is 3-0 with a 0.43 ERA in his last three starts with five walks and 25 strikeouts.
The Colorado Avalanche are now one game away from winning the Stanley Cup after a 3-2 overtime win on the road against the Tampa Bay Lightning in Wednesday's Game 4.
Tampa Bay were riding high after working their way back into the series with a dominant 6-2 showing in Game 3, but they now trail 3-1 in the series in their quest for three consecutive championships, with Game 5 headed back to Denver.
The Lightning were in control early as Anthony Cirelli scored the opening period's only goal, just 36 seconds into the action, dominating the opening period to force Avalanche goaltender Darcy Kuemper into 16 first-period saves. The visitors could only muster four shots on goal in comparison.
The Avalanche fought back into the contest in the second period, restoring parity thanks to Nathan MacKinnon's power-play goal, before Victor Hedman put the Lightning back in front heading into the third.
An early goal from Colorado's Andrew Cogliano put things even again at 2-2, which would hold through regulation and eight minutes of overtime until Nazem Kadri was slipped through by Artturi Lehkonen.
Kadri's shot deflected off Lightning goalie Andrei Vasilevskiy's stick and nestled into the top of the net in a hard-to-view position, with the Colorado bench eventually exploding into celebrations once they realised it was in the goal.
After the game, Kadri was asked if he knew he had scored with his winning shot.
"Not really," he admitted. "I just tried to make a little move there and go far-side, and I'm assuming that's where it went.
"I don't know if it found a hole, but it was a bit of a delayed reaction. I thought he made the save for a second, and the next thing you know people are sprinting towards me – it's a good feeling."
Playing in his first career Stanley Cup Final game in his return from thumb surgery, Kadri said he was determined to make it count.
"I've been waiting for this my whole life, so I figured I'd stop waiting and just try to join the party," he said.
"I'm just grateful I'm able to be in this position, and with this group of guys – you couldn't have written a better story.
"[Closing out the series] is going to be tough – the last one is the hardest one to win, everybody will tell you that.
"They're a great team over there, so we're expecting a good effort from them."
Avalanche star MacKinnon was complimentary of the efforts of Vasilevskiy – who denied a number of great chances in overtime before eventually conceding – but said he feels the right team won.
"[Vasilevskiy] was awesome – but it just felt like a matter of time, we really tilted the ice," he said.
"It just felt like we deserved it, we really outplayed them in overtime. We had a shaky first period, but other than that we were very solid.
"Obviously thrilled with the win, but short memory, we've got to move on and get ready for Friday night."
Acknowledging the extra fanfare that comes with a potential close-out game at home, MacKinnon said the key would be to not get caught up in the commotion.
"It starts with blocking out all the 'BS' that comes along with it," he said.
"Obviously we've got family and friends in town, we know what's going to be in the building, but have to stick to what's got us to this point.
"That's our great process – we put that before anything and we feel like the result will get done.
"Nothing changes, we have to stick to our game plan that we've been doing all season. I know it's cliche, but it's true.
"We're feeling good, we're going to be coming in attacking and aggressive, and hopefully get that win."
An explosive first inning and some big hitting from Yordan Alvarez lifted the Houston Astros to a 5-3 home win against the New York Mets on Wednesday.
It was a clash between two of the best teams in baseball, with the Mets entering the contest leading the National League at 45-25, and the Astros second in the American League at 42-25.
In a rough start for Mets pitcher Carlos Carrasco, the Astros started the game with a walk to Jose Altuve, followed by an RBI double to Michael Brantley, and then home runs to both Alex Bregman and Alvarez to lead 4-0 after the first four batters.
The Mets were able to pull one run back in the third, when Dominic Smith was brought home by a Brandon Nimmo sacrifice-fly, but Alvarez took that run straight back in the next inning when he crushed the longest hit of the game with a 412-foot homer to right-field.
Starling Marte's RBI double in the sixth inning cut the margin to 5-2, and Pete Alonso's sacrifice-fly brought home Marte for one more run, but that would be the last run of the game as both bullpens held out down the stretch.
Alonso's RBI was his league-leading 66th of the season – only Jose Ramirez (62 RBIs) and Paul Goldschmidt (58) have more than 52 this season as Alonso continues to put a gap on the field.
Astros starting pitcher Luis Garcia was credited with the win after giving up three runs in five innings, striking out five, and Ryan Pressly collected his 14th save of the season to close it out.
Wacha wins it for Boston
The Boston Red Sox rode a quality start from pitcher Michael Wacha to a 6-2 home win against the Detroit Tigers.
Wacha pitched six full innings as the Red Sox moved to an 8-2 record over the past 10 games, giving up two runs from hits and two walks, striking out seven in a terrific 98-pitch outing.
After giving up a two-run homer to Javier Baez in the first inning, the Boston pitching staff held the Tigers scoreless the rest of the way.
With the bat, exciting youngster Jarren Duran tied the game in the third inning with a two-run double, before Rob Refsnyder scored another two with his home run in the next at-bat.
Hays hits for the cycle
Baltimore Orioles centre-fielder Austin Hays hit for the cycle in his side's 7-0 home win against the Washington Nationals.
Batting lead-off, Hays opened the game with an infield single, and connected on a 405-foot home run in his next plate appearance in the third inning.
An inning later, he collected the toughest leg of the cycle when the right-hander sliced a drive into the right-field corner for a triple, and he completed the feat in his fourth at-bat with a two-run double to deep centre-field.
This all took place before the game was called off in the seventh inning due to persistent rain.
The Portland Trail Blazers are reportedly hoping to trade the seventh overall pick in Thursday's NBA Draft to the Toronto Raptors for starting wing O.G. Anunoby.
Chris Haynes' report came just an hour after it was announced that the Trail Blazers had acquired Jerami Grant in a trade from the Detroit Pistons in exchange for a Milwaukee Bucks first-round draft pick in 2025, which Portland received from the New Orleans Pelicans this past season in the C.J. McCollum trade.
Haynes is known to have a close connection to Trail Blazers star Damian Lillard, and has often been accurate in his reporting on the team.
While it is likely the Trail Blazers are interested in such a trade, it remains to be seen if the Raptors have any interest in moving the ascending 24-year-old, who is one of the best wing defenders in the entire league and averaged 17.1 points per game, 5.5 rebounds, 2.6 assists and 1.5 steals per game this past season.
Anunoby is young enough to still fit with the Raptors' timeline if they are in fact opting to reset and build around Rookie of the Year Scottie Barnes, so for this trade to realistically go ahead, the Trail Blazers would need to give up more than just one pick.
Fresh off their fourth NBA championship in eight seasons, the Golden State Warriors are planning to continue that run of success by bringing all their players back for a run at yet another title.
Championship teams rarely return exactly the same roster the following season and payroll issues need to be considered, but Warriors general manager Bob Myers would like to see the same team on the floor in 2022-23.
With seven free agents and the team already $24.6 million over the tax, Golden State has plenty of work to do this offseason.
The unrestricted free agents are Kevon Looney, Otto Porter Jr., Nemanja Bjelica, Andre Iguodala, Damion Lee, Gary Payton II and Juan Toscano-Anderson. Looney, Porter and Payton are the key pieces of that group, with Iguodala possibly retiring.
"Our goal, our hope is to bring all those guys back and try to do it again," Myers said. "They were all great in different ways and all fill different needs for us. A lot of our free agents had big moments in the NBA Finals, which means they’re pretty important."
Also on Myers’ extensive to-do list is contract extensions for Andrew Wiggins and Jordan Poole, though they might not be settled for a while. Poole had a breakout third season with 18.5 points per game and is up for a rookie extension. Wiggins, meanwhile, is entering the final year of his five-year contract from the Minnesota Timberwolves.
"All these negotiations take on a life of their own," Myers said. "They’re all different. But I know with a guy like Jordan, usually, those things come down to kind of training camp and end-of-the-line deadline. We’re a long way from figuring out what Andrew wants, but I do know what we want. We want to keep him, and we’re going to make every effort to keep both those guys. They were huge for us."
One key contributor that is sure to be back for the Warriors is assistant coach Kenny Atkinson, who backed out of the head coaching position with the Charlotte Hornets to stay with Golden State.
The Portland Trail Blazers have traded a 2025 first-round pick to the Detroit Pistons for 28-year-old forward Jerami Grant.
Grant, entering his ninth NBA season, will play for his fifth team after starting out his career with the Philadelphia 76ers, before more than two years with the Oklahoma City Thunder, one season with the Denver Nuggets, and finally signing with the Detroit Pistons for the past two seasons.
The pick Portland are trading is a Milwaukee Bucks first-rounder, acquired by the New Orleans Pelicans in exchange for Jrue Holiday, and then shipped to the Trail Blazers in the C.J. McCollum deal.
It is reportedly protected from picks one-through-four, which will only come into play if the Bucks finish as one of the worst teams in the league in the 2024-25 season.
As part of the deal, the Pistons also swapped second-round picks with the Trail Blazers, moving up from 46 to 36 in Thursday's NBA Draft.
Grant set new career-highs in both points and assists per game during his first year with the Pistons with 22.3 points and 2.8 assists, but both numbers dipped slightly this past season with the arrival of number one overall pick in the 2021 draft, Cade Cunningham.
The Trail Blazers have also reportedly been testing the waters to see what they could get in return for the seventh pick in this week's draft, and may have more moves up their sleeves in coming days.
Nick Kyrgios has lamented the ATP Tour trialling off-court coaching, warning tennis will lose one of the "unique traits that no other sport had".
The ATP announced on Tuesday that off-court coaching will be tested in the second half of the season, with coaching permitted by a designated person in qualifying and main draw matches.
Verbal coaching will be permitted when players are at the same side of the court as their coach, with non-verbal instructions – for example hand signals – allowed at any time.
Patrick Mouratoglou coached former world number one Serena Williams and now works with Simona Halep, and was quick to welcome the introduction.
Mouratoglou suggested the coaching methods have been used at "almost every match for decades".
While Mouratoglou was a vocal supporter of the ATP decision, Kyrgios – who pulled out of the Mallorca Championships with injury – hit back and slammed the proposed changes.
"Completely disagree. Loses one of the only unique traits that no other sport had," Kyrgios responded to Mouratoglou's post on Twitter.
"The player had to figure out things on his own. That was the beauty of it. What happens if a high-profile player versus a low-ranked player who doesn't have or [cannot] afford a coach?"
The trial commences on July 11 and will be evaluated at the end of the 2022 season, to assess the potential inclusion of off-court coaching in subsequent seasons.
Serena Williams lauded her doubles partner Ons Jabeur after they advanced to the semi-finals of the Eastbourne International on Wednesday.
Playing in her first tournament since retiring from the opening round of Wimbledon injured last year, Williams acknowledged she was particularly reliant on Jabeur during their 6-2 6-4 success over Shuko Aoyama and Chan Hao-ching.
The 23-time grand slam singles champion opted to only play doubles on the south coast as she gears up for a return to the All England Club.
"I think we played together much better," said Williams. "Although I thought we played really good together [against Maria Bouzkova and Sara Sorribes Tormo on Tuesday] too.
"But Ons really held me up. She was really playing so good. I was looking at her and was like, 'Wow, this is great.' It's good."
Williams and Jabeur will take on Aleksandra Krunic and Magda Linette for a place in the final.
Jabeur playfully asked the 40-year-old if she would like to play together at the US Open, to which the former world number one responded: "Sign me up!"
The Tunisian added: "I'm getting used to this. It was really great to play here and I didn't know we are in the semi-finals. It's super fast, but it's great for us."
Former NFL defensive tackle and TV analyst Tony Siragusa has died at 55 years old.
Indianapolis Colts owner Jim Irsay confirmed the death on Wednesday.
A member of the Baltimore Ravens Super Bowl championship team from the 2000 season, Siragusa was a fan favourite during his 12 professional seasons due to his jovial, larger-than-life personality that matched his massive frame.
Undrafted out of Pittsburgh, Siragusa signed with the Colts in 1990 and spent his first seven seasons in Indianapolis before joining the Ravens in 1997. He finished his career with 564 total tackles, 22 sacks and nine fumble recoveries in 169 games.
Following his retirement after the 2001 season, Siragusa spent more than a decade as a sideline reporter and analyst for NFL games on Fox. He was known for providing his commentary from the sidelines during game broadcasts as opposed to the traditional analyst role in a TV booth.
Ravens owner Steve Bisciotti said in a statement: "Renee and I are stunned and heartbroken to learn about the sudden passing of Tony Siragusa.
"He was a special person and clearly one of the most popular players in Ravens history.
"Tony's larger-than-life personality made an enormous impact on our organisation and throughout the Baltimore community.
"On the football field, Goose was a difference-maker who contributed immeasurably to the success of many great Ravens defenses, including the record-setting 2000 Super Bowl team.
"Our deepest prayers and sympathies go out to Kathy, their three children and the rest of the Siragusa family."
A native of New Jersey, Siragusa also dabbled in acting following his NFL career, playing a recurring character on the TV series 'The Sopranos'.
The announcement of Siragusa's passing comes on the same day the Ravens confirmed the death of linebacker Jaylon Ferguson at the age of 26.
"This is a tremendously sad day for the Baltimore Ravens," Bisciotti added. "We appreciate everyone who has expressed an outpouring of support for our players, coaches and staff."
Daniil Medvedev eventually mastered the windy conditions as he came from behind to keep his Mallorca Championships defence alive, but Jannik Sinner and Diego Schwartzman crashed out in Eastbourne.
World number one Medvedev fought back from a set down to defeat Aslan Karatsev 3-6 6-4 6-2 and advance to a quarter-final against fifth seed Roberto Bautista Agut, who was granted a walkover after Nick Kyrgios pulled out with an abdominal issue.
The Russian got just 48 per cent of his first serves in during a blustery opening set before improving to 68 per cent in the second and controlling the decider as Karatsev struggled with injury.
"It was tough to play [in] rhythm. It felt like many points were just whoever managed to put the ball in the court was going to win the point," Medvedev said of the tricky conditions.
"It was not easy but I'm happy to win because that's the most important [thing].
"Last year was amazing. I played great tennis. Hopefully I can do the same this year. I like it here in Mallorca, so hopefully I can stay as long as possible in the tournament."
Alongside Medvedev and Bautista Agut, Stefanos Tsitsipas is the only other seed left in the draw after he overcame Ilya Ivashka 6-4 6-4.
Denis Shapovalov was a 6-4 6-1 loser against Benjamin Bonzi, Pablo Carreno Busta went down 6-3 6-4 to Antoine Bellier and Sebastian Baez's meeting with Daniel Altmaier ended in a 6-2 2-6 6-4 defeat for the Argentine.
At the Eastbourne International, second seed Sinner suffered a 6-3 3-6 6-3 loss to Tommy Paul as he made his return from a knee injury sustained at the French Open.
World number 13 Sinner remains without a grass-court win in his ATP Tour career, while Paul will next face defending champion Alex de Minaur, who overcame Lorenzo Sonego 7-6 (7-3) 6-2 in a repeat of last year's final.
Jack Draper defeated fourth seed Diego Schwartzman 7-5 7-6 (7-3) to advance to the quarter-finals and Cameron Norrie cruised past Brandon Nakashima in straight sets.
There were also wins for Maxime Cressy, Alexander Bublik and Taylor Fritz.
Garbine Muguruza saw her Wimbledon preparations take a hit as she fell to a last-16 defeat at the Eastbourne International on Wednesday.
World number 26 Camila Giorgi battled from a break down in both sets to beat fifth seed Muguruza 7-5 6-3 in an hour and 53 minutes.
That meant 12th seed Giorgi made her second straight quarter-final, following a last-eight appearance in Birmingham, and will next face Viktoriya Tomova, who defeated Kirsten Flipkens 3-6 6-3 6-4.
Jil Teichmann, the 10th seed at the tournament, was a notable second-round elimination, falling to a 7-6 (9-7) 4-6 6-3 defeat to Briton Harriet Dart, who later triumphed 6-4 2-6 6-4 over Marta Kostyuk.
Dart's fellow Briton Katie Boulter stunned last year's Wimbledon runner-up Karolina Pliskova in the second round but had no such luck against Petra Kvitova, losing 5-7 6-0 7-5.
Beatriz Haddad Maia, the winner at the Birmingham Open last week, extended to a 12-match winning streak with a 6-1 6-2 victory over Jodie Burrage.
Jelena Ostapenko also progressed after Madison Keys retired when 6-3 down and will next face Anhelina Kalinina, who battled to a 6-3 2-6 6-3 win over 16th seed Yulia Putintseva.
While seeds fell at Eastbourne, there were not as many shocks at the Bad Homburg Open, where Angelique Kerber defeated Lucia Bronzetti 6-2 6-3 to reach the quarter-finals.
Fourth seed Simona Halep also made the last eight with 6-0 6-3 victory over Tamara Zidansek and will meet Amanda Anisimova after she won an All-American match against Ann Li 6-0 6-2.
Alize Cornet downed Tatjana Maria 7-6 (7-4) 6-4 to tee up a clash with Kerber, while Bianca Andreescu will meet top seed Daria Kasatkina after defeating Katie Swan 6-4 6-4.
The PGA Tour has announced schedule changes and prize money increases in order to stem the flow of big-name players joining the rival LIV Golf International Series.
Brooks Koepka became the ninth major champion to sign up to the controversial Saudi Arabia-backed league, rocking the PGA Tour on Wednesday.
The American joined Sergio Garcia, Dustin Johnson, Phil Mickelson, Martin Kaymer, Graeme McDowell, Louis Oosthuizen, Charl Schwartzel and Bryson DeChambeau in the breakaway competition.
Defecting players were indefinitely suspended from PGA Tour events, but were allowed to play at last week's U.S. Open and participate in next month's 150th Open at St Andrews.
The PGA had been rumoured to be mulling over a switch to a calendar-year schedule, alongside increased purses and the creation of new no-cut international events featuring the Tour's top 50 players.
Commissioner Jay Monahan confirmed those alterations at a press conference ahead of the Travelers Championship, stressing the PGA's need to innovate to remain golf's leading competition.
"I want to talk about where the PGA Tour is headed. We don't expect to overcome this current challenge by relying on our legacy and track record alone," he said.
"We've been on a path for a number of years to strengthen and evolve our product for the benefit of our fans and players alike, those plans are obviously accelerated in light of the current environment.
"We have some exciting developments coming out of yesterday's policy board meeting that will further secure our status as the pre-eminent golf tour in the world.
"This includes moving forward with our future product model for the 2022-23 season and beyond, a return to a calendar-year schedule beginning in 2024, with the FedEx Cup contested from January to August, culminating with the FedEx Cup play-offs and followed by the fall events.
"[The Tour will also add] revised field sizes for the FedEx Cup play-offs in 2023 and beyond, [and] the creation of a series of up to three international events, to be played after the conclusion of the fall schedule, which will include the top 50 players from the FedEx Cup points list.
"Alongside these changes, the policy board also amended the resource allocation plan, to increase purse sizes at eight events during the 2022-23 season, with an average purse at $20million.
"There is more work to be done, and details to confirm, but implementing substantial changes to our schedule gives us the best opportunity to not only drive earnings to our players, but also improve our product and create a platform for continued growth in the future."
Rory McIlroy, a vocal opponent of LIV Golf, had earlier stated he supported the changes, saying to Sky Sports: "I think having the FedExCup season go to a calendar year, that would be a pretty good idea.
"So then it gives guys the opportunity to play if they want to play in the fall, or if they don't want to play in the fall they don't have to, they're not forced to.
"You're trying to give playing opportunities and create prize funds for the lower half of the membership, but also trying to accommodate what the upper half of the membership want as well with an off-season, time away from the FedExCup schedule. So it's a balance."
Monahan added the PGA could not wish to compete financially with the rival tour, headed by two-time major champion Greg Norman, which he described as "irrational".
"I am not naive," Monahan said. "If this is an arms race and if the only weapons are dollar bills, the PGA Tour can't compete with a foreign monarchy that is spending billions of dollars in an attempt to buy the game of golf.
"We welcome good healthy competition, the LIV series is not that. It's an irrational threat, one not concerned with the return on investment or true growth of the game.
"Currently no one organisation owns or dominates the game of golf, instead the various entities work together to meet our own respective priorities but with the best interests of the game at heart.
"When someone attempts to buy the sport and dismantle the institutions that are intrinsically invested in growth and focus only on a personal priority, that partnership evaporates.
"Instead we end up with one person, one entity, using endless amounts of money to direct employees towards their personal goals, which may or may not change tomorrow or the next day.
"I doubt that's the vision any of us have for the game."
Rory McIlroy labelled breakaway players joining the LIV Golf International Series as "duplicitous" before Brooks Koepka became the latest high-profile name to leave the PGA Tour.
McIlroy has been a critic of LIV Golf, the controversial Saudi-backed competition, with opponents accusing the breakaway league of sportswashing.
However, that has not stopped the likes of Dustin Johnson, Phil Mickelson, Bryson DeChambeau and Sergio Garcia leaving the PGA Tour, who have indefinitely banned the defectors from returning.
Koepka was confirmed on Wednesday as the next big name to join and is the ninth major winner to sign for LIV Golf, with world number 20 Abraham Ancer also being linked with the tournament.
Four-time major winner Koepka refused to discuss LIV Golf at last week's U.S. Open, where he said he was "tired of conversations" and debates were "throwing a black cloud" over the third major of 2022.
Koepka subsequently withdrew from the Travelers Championship, which is the next PGA Tour event on Thursday, and will feature at the second LIV Golf event in Portland.
That has led to more debate around the breakaway league, and McIlroy feels his fellow golfers are not staying true to their word.
"Am I surprised?" McIlroy told reporters in Connecticut before Koepka's switch was confirmed. "Yes, because of what he said previously.
"I think that's why I'm surprised at a lot of these guys because they say one thing and then they do another, and I don't understand that and I don't know if that's for legal reasons or if they can't – I have no idea.
"But it's pretty duplicitous on their part to say one thing and then do another thing…the whole way through, in public and private, all of it."
McIlroy has enjoyed an upturn in fortunes over the last month, triumphing at the Canadian Open before finishing in a tie for fifth at the U.S. Open.
The 33-year-old admitted that tiredness is becoming a factor as he prepares for his fourth tournament in as many weeks, but remains excited to compete at the Travelers Championship.
"I got a night in my own bed down in Florida on Monday night, which was really nice," he added.
"But, yes, I came back up here yesterday and played the pro-am today and going to get an early night tonight. I've got an early start again tomorrow.
"But excited to get going and especially continuing the run of form I'm on. I'm playing some really good golf and I want to continue trying to do that.
"I think the three weeks that I've played, like Memorial's a very demanding golf course. Canada wasn't so demanding but when you get yourself in contention and you play a weekend like that, then that takes quite a lot out of you. And then you follow that up with a US Open. So I think it's a combination of everything.
"Mentally I'm totally fine, but it will be nice to sort of rest up this afternoon and get another good night's sleep and get ready to play tomorrow.
"But four weeks in a row is pretty rare for me these days. I haven't played four in a row in a while and you start to remember why!"
Brooks Koepka has become the latest high-profile player to trade the PGA Tour for the LIV Golf Invitational Series.
The likes of Phil Mickelson, Dustin Johnson and Sergio Garcia were among the early joiners of the Saudi Arabia-backed breakaway competition, which started earlier in June in London.
Bryson DeChambeau and Patrick Reed followed suit as they announced their intention to play in LIV Golf tournaments, with all participants aware they would be indefinitely suspended from the PGA Tour.
The breakaway golfers were still allowed to participate at the U.S. Open, where Koepka said he was "tired of conversations" about the new circuit and asserted LIV Golf debates were "throwing a black cloud" over the third major of 2022.
Four-time major winner Koepka, who finished 55th at Brookline, then removed all references to the PGA Tour from his social media profiles as expectations grew that he would trade allegiances.
The world number 19's move was subsequently confirmed on Wednesday and he will feature in the second event at Pumpkin Ridge in Portland, Oregon, which starts on July 3.
"There's no understating the impact that Brooks Koepka has had on the game of golf in the last five years," LIV Golf chief executive Greg Norman said.
"He carries a championship pedigree and record of success as one of the most elite players in the world
"The addition of Brooks is yet another example of the incredible fields LIV Golf is assembling as we build momentum in our first season and look towards the future."
Six further tournaments will follow for LIV Golf this season, with the total prize fund for the eight competitions £200million, with Charl Schwartzel collecting £3.9m when he won the opening 54-hole competition.
Uncertainty remains as to what the breakaway league means for further participation at the majors, with USGA chief executive Mike Whan admitting he could foresee a day where players may be banned.
Koepka becomes the ninth major champion to defect to LIV Golf, along with Garcia, Johnson, Mickelson, Martin Kaymer, Graeme McDowell, Louis Oosthuizen, Schwartzel and DeChambeau.
World ranking points remain unavailable for LIV Golf events, but Norman – himself a two-time major champion – has said an application for that to change has been submitted.
Rafael Nadal proved his fitness on his return to action ahead of Wimbledon with a routine straight-sets victory over Stan Wawrinka in Wednesday's exhibition match.
The 37-year-old has won the Australian Open and French Open titles already this year, but his bid for a grand slam sweep was halted by a troublesome foot problem.
Nadal triumphed at Roland Garros despite needing pain-killing injections before every match, leaving his fitness in doubt for Wimbledon next week.
However, the 22-time grand slam winner confirmed last week he was planning on taking part in the third major of the year after spending time training on grass in Mallorca.
And in his first match since beating Casper Ruud in the French Open final two-and-a-half weeks ago, Nadal eased past Wawrinka at the Hurlingham Club in London.
The Spaniard raced into a five-game lead in the opener and, despite losing his break of serve in the seventh game, saw out a straightforward opening set.
Playing in front of around 1,300 spectators, Nadal was pushed a little harder in the second set but still came through relatively unscathed to win 6-2 6-3 in a little over an hour.
Wawrinka, who has been handed a wild card for Wimbledon, expects Nadal to be right in the mix for a third crown at All England Club, 12 years on from his most recent triumph.
"After that I have a lot to work on," he joked. "But it's OK, it's against Rafa. We are used to losing against him. It's normal!.
"I don't know how he's feeling – it looks like normal Rafa. He has been saying he is feeling better and if he is playing he is ready to play his best and to win.
"I think Rafa any time he enters a grand slam is going to be one of the favourites, if not the favourite.
"He won the first two slams of the year without too many matches before those grand slams so he got a lot of confidence so of course he is part of the favourites."
As well as twice winning Wimbledon, Nadal has also reached the semi-finals in his past two appearances in 2018 and 2019.
After getting a first grass-court appearance in three years under his belt, he is hoping for more happy memories during his time in the English capital.
"I have spent some fantastic moments here in London," he said. "Playing of course at the World Tour Finals a lot of times but of course playing at Wimbledon since 2003.
"It was always a big goal and a dream for me to achieve important things here at Wimbledon and I was able to make that happen for the first time in 2008.
"Since that moment, I always come back with the same passion and I always feel very welcomed by the crowd here."
Nadal will be number two seed when the draw takes place on Friday, with long-time rival Novak Djokovic the top seed in the absence of Daniil Medvedev.
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