Two-time Miami Open champion Andy Murray has been eliminated in the first round of this year's event after a shock 6-4 7-5 loss to world number 76 Dusan Lajovic on Wednesday.

Murray, ranked 53rd in the world, could not find his usual return with Lajovic winning 72 per cent of second-serve points, prevailing in one hour and 38 minutes.

The Serbian claimed only his fourth win out of 16 matches on hard courts since the start of last year, holding his nerve after failing to serve out the match at 5-4 in the second set, converting his third match point in the 12th game.

Lajovic hit 21-14 winners, with Murray committing more unforced errors (15-13). The Serbian converted all three break points he generated.

Former world number six Gael Monfils was forced to retire due to a right wrist injury in his clash with French compatriot Ugo Humbert at 3-3.

Monfils, 36, was playing at only his third event since returning to the ATP Tour following seven months out due to injury.

Argentina's Facundo Bagnis defeated Brazilian qualifier Felipe Meligeni Alves 6-3 1-6 6-4, with his reward a second-round clash with last week's Indian Wells Open winner and top seed Carlos Alcaraz.

World number 50 J.J. Wolf beat world number 48 Alexander Bublik 7-5 6-3 in 79 minutes, earning a second-round clash with sixth seed Andrey Rublev.

World number 74 Martin Fucsovics sent down nine aces as he beat Argentina's Pedro Cachin 6-4 7-6 (7-2) in 107 minutes. Fucsovics will next face seventh seed Holger Rune.

Ilya Ivashka beat Daniel Altmaier 6-2 6-1 to book a second-round clash with third seed Casper Ruud, while Fabio Fognini bowed out, losing 6-4 5-7 6-4 to Jan-Lennard Struff. USA's Brandon Nakashima powered to a 7-6 (7-3) 6-3 victory over Germany's Oscar Otte.

Jack Sock is through to the second round of the Dallas Open after prevailing 7-6 (7-2) 4-6 6-4 in a tough opening test against Ilya Ivashka.

Belarus' Ivashka is ranked over 50 spots higher than Sock, but he is in some torrid form, with Monday's loss his sixth in a row.

Sock snapped his own three-match losing streak, and he did so despite committing 10 double faults, coming up clutch in break point situations by saving 15 of Ivashka's 18 opportunities.

Meanwhile, 21-year-old Argentinian Juan Manuel Cerundolo booked a meeting with compatriot and top seed Diego Schwartzman after beating Pablo Andujar 6-4 1-0 (retired) in the first round of the Cordoba Open.

The rising Cerundolo now boasts a 13-1 record since the beginning of the new year, while it was Andujar's fifth loss in a row.

In an all-Spanish showdown it was Bernabe Zapata Miralles emerging victorious 6-7 (6-8) 6-3 7-5 against Roberto Carballes Baena, while Serbia's Dusan Lajovic defeated Peru's Juan Pablo Varillas 7-6 (7-3) 6-3.

The last match of the night saw Italy's Luciano Darderi handle France's Hugo Gaston 6-4 6-3, with Darderi now set to face fourth seed Sebastian Baez.

Frances Tiafoe was an impressive winner of his quarter-final matchup against Brandon Nakashima in Friday's action at the Atlanta Open, cruising in straight sets 6-4 6-2.

Tiafoe, the fourth seed, was in control throughout, capitalising on a pair of double faults in the first set to grab the early break. 

He also had a clear advantage with his second serve, winning 76 per cent of those opportunities (13-of-17) compared to 36 per cent for Nakashima (five-of-14).

Tiafoe will play Jenson Brooksby in the semi-final after he defeated big-serving 37-year-old John Isner 3-6 6-1 6-4.

Isner's serve was uncharacteristically vulnerable after the first set, winning 90 per cent of his successful first serves in the opener, before that number plummeted to 46 per cent in the second, and 59 per cent in the last.

Ilya Ivashka pulled off the upset of the day by knocking out fifth seed Tommy Paul, continuing a terrific run of form. Ivashka is now 7-3 from his past 10 matches, with his three-losses coming against superstars Stefanos Tsitsipas and Daniil Medvedev (twice).

He will play Australian Alex de Minaur in the other semi-final after he came from a set behind to run over the top of Adrian Mannarino 4-6 6-3 6-0.

Mannarino showed he has what it takes to compete with a top-30 talent like De Minaur, but the 34-year-old simply ran out of gas towards the end of the second set.

In the deciding set, De Minaur won 70 per cent of his points on serve (14-of-20) and 72 per cent of his return points (13-of-18).

Daniil Medvedev eventually mastered the windy conditions as he came from behind to keep his Mallorca Championships defence alive, but Jannik Sinner and Diego Schwartzman crashed out in Eastbourne. 

World number one Medvedev fought back from a set down to defeat Aslan Karatsev 3-6 6-4 6-2 and advance to a quarter-final against fifth seed Roberto Bautista Agut, who was granted a walkover after Nick Kyrgios pulled out with an abdominal issue. 

The Russian got just 48 per cent of his first serves in during a blustery opening set before improving to 68 per cent in the second and controlling the decider as Karatsev struggled with injury. 

"It was tough to play [in] rhythm. It felt like many points were just whoever managed to put the ball in the court was going to win the point," Medvedev said of the tricky conditions. 

"It was not easy but I'm happy to win because that's the most important [thing]. 

"Last year was amazing. I played great tennis. Hopefully I can do the same this year. I like it here in Mallorca, so hopefully I can stay as long as possible in the tournament." 

Alongside Medvedev and Bautista Agut, Stefanos Tsitsipas is the only other seed left in the draw after he overcame Ilya Ivashka 6-4 6-4. 

Denis Shapovalov was a 6-4 6-1 loser against Benjamin Bonzi, Pablo Carreno Busta went down 6-3 6-4 to Antoine Bellier and Sebastian Baez's meeting with Daniel Altmaier ended in a 6-2 2-6 6-4 defeat for the Argentine. 

At the Eastbourne International, second seed Sinner suffered a 6-3 3-6 6-3 loss to Tommy Paul as he made his return from a knee injury sustained at the French Open.

World number 13 Sinner remains without a grass-court win in his ATP Tour career, while Paul will next face defending champion Alex de Minaur, who overcame Lorenzo Sonego 7-6 (7-3) 6-2 in a repeat of last year's final. 

Jack Draper defeated fourth seed Diego Schwartzman 7-5 7-6 (7-3) to advance to the quarter-finals and Cameron Norrie cruised past Brandon Nakashima in straight sets.

There were also wins for Maxime Cressy, Alexander Bublik and Taylor Fritz. 

Ilya Ivashka earned a meeting with Stefanos Tsitsipas at the Mallorca Championships, while Alex de Minaur got his Eastbourne International defence up and running with a straight-sets win on Monday.

A comfortable 6-4 6-1 victory over Emil Ruusuvuori sent Ivashka into the second round, where world number six Tsitsipas awaits after receiving a bye.

Mallorca third seed Denis Shapovalov will face Benjamin Bonzi who benefited as Alejandro Tabilo retired while trailing 6-3 4-2 to the Frenchman.

Roberto Bautista Agut overcame Taro Daniel 6-4 7-6 (7-4) to advance, while Antoine Bellier defeated Federico Delbonis 6-3 7-6 (8-6) and Feliciano Lopez fell to a 7-6 (7-3) 7-6 (7-3) loss to Tallon Griekspoor.

De Minaur took an hour and 23 minutes to get past Cristian Garin 6-3 6-3 for a strong start in his bid to retain the trophy in Eastbourne.

The Australian will either face compatriot James Duckworth or Lorenzo Sonego, who he defeated in the final last year, in round two.

Fifth seed Reilly Opelka fell to a 6-3 6-1 defeat against tournament debutant Maxime Cressy, while Alexander Bublik was three points away from losing to Frances Tiafoe before rallying back to win 5-7 7-6 (7-4) 6-0.

Bublik will face John Millman next after the Australian overcame Sebastian Korda 6-3 7-6 (7-5), while top seed Cameron Norrie awaits Brandon Nakashima and Diego Schwartzman is next in line for Jack Draper.

Korda withdrew from Wimbledon after the defeat to Millman, the 21-year-old American saying on Twitter he was suffering with "terrible shin splints and beaten up feet" and needed a rest.

Novak Djokovic again overcame the challenge of a fellow home favourite to advance to the semi-finals at the Serbia Open on Thursday. 

The world number one had battled from a set down against Laslo Djere 24 hours earlier and was once more made to work hard for his win versus Miomir Kecmanovic. 

The seventh seed took the opener without facing a break point and led early in the second set too. 

But Kecmanovic could not hold off Djokovic, who recovered to win 4-6 6-3 6-3 and reach the last four for the fourth time in five campaigns in Belgrade. 

After two victories in two nights against Serbians for the two-time winner, Djokovic is on a 10-0 run in matches with his compatriots and 27-4 all-time. 

The 20-time grand slam champion also has a 36-6 record in Serbia and has particularly enjoyed the "strange" opportunity to face his countrymen in front of a home crowd. 

"It's a very strange feeling, sharing the court with your compatriots," he said. "Obviously the crowd was phenomenal for both players in yesterday's match and today's. 

"They're very rare occasions when I'm able to play at home and experience this atmosphere, so I'm trying to enjoy every single moment." 

Djokovic is the last Serbian remaining in the tournament, though, and takes on third seed Karen Khachanov – a winner against Thiago Monteiro – in the semis. 

There remain two quarter-finals to play on Friday, as Andrey Rublev faces Taro Daniel while Fabio Fognini welcomes the challenge of Oscar Otte. 

Meanwhile, there were only two matches completed at the Barcelona Open due to rain, but Ilya Ivashka ensured fans were rewarded for their patience as he took Stefanos Tsitsipas the distance. 

Ivashka eventually went down 6-1 4-6 6-2 to the top seed in a heavily delayed second-round contest.