Coco Gauff dispatched Zhang Shuai in straight sets to become the youngest US Open quarter-finalist in 13 years.
The 18-year-old American fan favourite won 7-5 7-5 on Sunday, sealing her place in the last eight.
Gauff's victory makes her the youngest player to have reached the quarters at Flushing Meadows since Melanie Oudin in 2009.
Oudin, another American, was 17 at the time, and lost her last-eight tie to eventual runner-up Caroline Wozniacki.
Caroline Garcia is next up for Gauff, who will face either Ons Jabeur or Ajla Tomljanovic should she overcome the US Open quarter-final debutant.
Australia's Tomljanovic followed up her defeat of Serena Williams with a 7-6 (10-8) 6-1 win over Liudmila Samsonova, snapping the Russian's 13-match winning streak and reaching her second career grand slam quarter-final in the process.
World number five Jabeur, meanwhile, made history by becoming the first North African woman to make the US Open quarter-finals in the Open Era.
She is the third woman from the African continent to do so, with South Africans Maryna Godwin (1968) and Amanda Coetzer (1994, 1996 and 1998) having previously achieved the feat. Jabeur defeated Veronika Kudermetova 7-6 (7-1) 6-4.
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