Novak Djokovic will return to the top of the ATP rankings after Daniil Medvedev fell to a brilliant Gael Monfils comeback at the Indian Wells Open.

Medvedev was beaten 4-6 6-3 6-1 by Frenchman Monfils, with the reigning US Open champion only able to connect on 50 per cent of his first serves, while he was broken three times in the decider.

For Monfils, the win earns him a spot in the fourth round against Carlos Alcaraz, while the loss means Medvedev will lose his position as world number one after only two weeks.

Speaking to post-match media, Medvedev said while he will work hard to earn the top-ranking back, starting in Miami next week.

"Is it better to be number one for, let’s say one week in your life, or never touch it?" he said. "I think it's still better to at least touch it.

"Now I know I'm going to lose it, so I have Miami to try to get it back. [I'm] usually feeling a little bit better in Miami in terms of tennis, so I'll try to play good there.

"I thought it could give me more motivation, well, I had motivation. It's just that I didn't find my best tennis."