Novak Djokovic was beaten in his first match back in Australia but did at least receive a warm reception from the crowd at the Adelaide International.
Djokovic – who saw a three-year visa ban lifted in November – was playing with Vasek Pospisil in the doubles, and the duo lost 4-6 6-3 10-5 to Tomislav Brkic and Gonzalo Escobar on Monday, but the fans in attendance chanted "Novak" as they welcomed him back following his absence from last year's Australian Open.
The Serbian will face Constant Lestienne in the first round of the men's singles, but second seed Felix Auger-Aliassime is already out after he lost to Alexei Popyrin.
Auger-Aliassime struggled throughout as his Australian opponent, ranked 120th in the world, put in a crowd-pleasing performance to go through 6-4 7-6 (7-5).
Another young star, Holger Rune, is also out after the fifth seed was beaten 2-6 6-4 6-4 by Yoshihito Nishioka.
Quentin Halys set up a potential second-round clash with Djokovic after beating Jordan Thompson in straight sets, while Miomir Kecmanovic, Jack Draper, Roman Safiullin and Thanasi Kokkinakis all progressed.
It was also a bad day for seeds at the Maharashtra Open in Pune, with Alex Molcan beaten 6-2 6-4 by Laslo Djere and Jaume Munar losing 6-4 7-5 to Tallon Griekspoor.
Dutchman Griekspoor will now play Marco Cecchinato after the Italian overcame Nikoloz Basilashvili, and Roberto Carballes Baena set up a last-16 clash against top seed Marin Cilic by defeating fellow Spaniard Bernabe Zapata Miralles.
Filip Krajinovic did make it through a tussle with home favourite Sumit Nagal to set up a meeting with Michael Mmoh, while Benjamin Bonzi will face third seed Emil Ruusuvuori after beating Tseng Chun-hsin.