The Green Bay Packers are waiting to discover the severity of an injury suffered by quarterback Jordan Love in the closing stages of their Week 1 loss to the Philadelphia Eagles.

The Packers were beaten 34-29 by Philadelphia in the NFL's first international game in Sao Paulo, letting a halftime lead slip as debutant Saquon Barkley inspired the Eagles to victory.

Running back Barkley rushed for 109 yards and two touchdowns as well as catching two Jalen Hurts passes for 23 yards and another score, becoming the first player with three touchdowns on their Eagles debut since Terrell Owens in 2004.

Things got worse for the Packers on the final drive of the game, as Love dropped back to pass and was caught between Eagles defensive tackle Jalen Carter and outside linebacker Josh Sweat.

Love appeared to twist his lower left leg and had to be helped from the field, with Malik Willis coming in to take the final two snaps as Green Bay failed to fight back.

Love's injury came in his first game since he was handed a new four-year, $220million contract that made him the league's joint-highest paid player, leaving the Packers nervous about his condition.

"That's the franchise right there," defensive lineman Kenny Clark said. "Hopefully, he can be back next week and he can be all right."

Head coach Matt LaFleur was twice asked about Love's condition in his post-game press conference, simply responding: "I don't know".

Love completed 17 of his 34 passing attempts in Friday's game for 260 yards, two touchdowns and one pick.

The Packers are next in action versus the Indianapolis Colts at Lambeau Field on September 15, before visiting the Tennessee Titans for their first road game one week later.