The San Francisco 49ers will host the Seattle Seahawks in the opening game of the Wild Card round.

San Francisco progressed to the postseason as the NFC second seed, and have home field advantage in the first game of this season's playoffs, which will take place on Saturday.

The Seahawks defeated the Los Angeles Rams in overtime in their final regular-season game and were subsequently handed a favour by the Detroit Lions, who eliminated the Green Bay Packers and Aaron Rodgers from playoff contention.

In Saturday's second game, the Los Angeles Chargers travel to Florida to take on the Jacksonville Jaguars, who clinched the AFC South title with a 20-16 win over the Tennessee Titans.

A day later, the Buffalo Bills, who beat the New England Patriots in an emotional game on Sunday, will host the Miami Dolphins.

The Cincinnati Bengals, whose January 2 game against the Bills was suspended and subsequently cancelled altogether following Damar Hamlin's cardiac arrest, go up against the Baltimore Ravens in Sunday's final game, after the New York Giants have taken on the Minnesota Vikings.

The Wild Card round concludes with the Dallas Cowboys' trip to face Tom Brady's Tampa Bay Buccaneers.