Kyler Murray said he only saw DeAndre Hopkins after the pair combined for a Hail Mary touchdown in the Arizona Cardinals' win over the Buffalo Bills.

Hopkins made an incredible catch from Murray's 43-yard pass with two seconds remaining to see the Cardinals edge the Bills 32-30 on Sunday.

The wide receiver jumped against three Bills, but managed the catch for the game-winner.

Murray found it difficult to describe Hopkins' catch after the Cardinals' win, as they improved to 6-3.

"The play was designed for me to get out left, they had a guy containing, had to make him miss," the Cardinals quarterback told reporters.

"As funny as it sounds I felt like the only person I saw down there was 'Hop', let it go, give him a chance and it's funny … there was a group of four people and all I saw was black gloves. I'm just glad he caught the ball."

He added: "I've never played receiver so I'm thinking he's got to run down there, that's a 50-yard trot down there, and then he's got to post up with three dudes that are NFL athletes.

"I don't know, that's a tough catch, it's tough."

Murray completed 22 of 32 passes for 245 yards, the Hopkins touchdown and an interception, while he rushed for two scores.

The top pick in the 2019 NFL Draft, Murray became the first player in NFL history with a pass TD and a rush TD in five straight games, as per Stats Perform.

Hopkins, who finished with 127 receiving yards, said he simply wanted to put himself in position to make the game-winning play.

"I seen him scrambling around, I knew he was going to try to hopefully try to get us the ball or give me the ball or one of the big guys downfield that can go up and pinpoint it, Larry [Fitzgerald], Dan [Arnold], one of us," he said.

"I saw him back there doing what he do, making guys miss, I knew I needed to put myself in position if it came my way."