Jimmy Garoppolo will miss the San Francisco 49ers' clash with the New York Giants on Sunday because of a right high ankle sprain, with Nick Mullens starting in his place at quarterback.

Head coach Kyle Shanahan confirmed Mullens would play in an interview with KNBR on Friday.

Garoppolo was one of a host of 49ers to sustain injuries in their Week 2 win over the New York Jets at MetLife Stadium, where the Niners will face the 0-2 Giants.

Defensive linemen Nick Bosa and Solomon Thomas were each lost for the year to torn anterior cruciate ligaments while running backs Raheem Mostert and Tevin Coleman sustained knee injuries that will keep them out against the Giants.

Star tight end George Kittle, who suffered a sprained knee and a bone bruise in the Week 1 loss to the Arizona Cardinals, will play only if there is no hesitation from himself or the team's medical staff, Shanahan said.

Garoppolo completed 14 of his 16 pass attempts for 131 yards and two touchdowns in the first half against the Jets before Mullens replaced him in the second half.

An undrafted free agent out of Southern Mississippi, Mullens started eight games of a 2018 season that saw Garoppolo tear his ACL in Week 3.

Mullens went 3-5 as a starter, completing 64.2 percent of his passes for 2,277 yards, 13 touchdowns and 10 interceptions.