Deshaun Watson was not charged by a grand jury after it considered evidence of sexual assault and misconduct allegations on Friday.
The Houston Texans quarterback faces 22 civil lawsuits, but jurors did not find enough evidence for criminal proceedings.
Watson had strenuously denied the accusations since they emerged last year, overshadowing talk of a trade away from the Texans.
The 26-year-old did not play a single game in 2021, having led the NFL in passing yards in 2020.
"After a Harris County grand jury was presented all the evidence and had the opportunity to hear from all witnesses, grand jurors declined to indict Deshaun Watson," Dane Schiller, spokesman for the Harris County District Attorney's Office, said in a statement released to Stats Perform.
"Grand jury proceedings are secret by law, so no information related to their inquiry may be disclosed."
A widely released statement from Rusty Hardin, Watson's attorney, said: "We are delighted that the grand jury has looked at the matter thoroughly and reached the same conclusion we did.
"Deshaun Watson did not commit any crimes and is not guilty of any offences.
"Now that the criminal investigations have been completed, we are happy to move forward with the civil case depositions. We will vigorously defend those cases with every ounce we have."
Watson has been the subject of an investigation from the NFL, and the league said: "We have been closely monitoring all developments in the matter which remains under review of the personal conduct policy."
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