Derrick Henry's dominance continued as the Tennessee Titans comfortably beat the Indianapolis Colts in the NFL on Sunday.

Henry, a 2019 Pro Bowler, rushed for 178 yards and three touchdowns in the Titans' 45-26 victory at Lucas Oil Stadium.

It marked Henry's eighth straight road game with 100-plus rushing yards.

He tied former Titans running back Chris Johnson for the second longest streak since the 1970 merger, as per NFL Research. Only Barry Sanders (10 games) has had a longer streak.

Henry rushed for the game's opening touchdown, carrying the ball five times for 42 yards in the drive.

He scored another two touchdowns in the second quarter, the Titans opening up a 35-14 half-time lead.

The game was Henry's third with 175-plus rushing yards and three-plus rushing touchdowns.

He joined Hall of Famers Jim Brown (five games) and LaDainian Tomlinson (three), as well as Adrian Peterson (three), as the only players in NFL history with three such games in their first five seasons.

The crucial win saw the Titans (8-3) go top of the AFC South ahead of the Colts (7-4).

Henry is the only player with 100-plus rushing yards against the Colts since 2018, and he has managed it three times.

He surpassed 5,000 career rushing yards and reached 50 rushing touchdowns in the win.

Henry entered Week 12 with the most rushing yards in the NFL this season and an average of 107.9 rushing yards per game – a career-high.

The Titans face the Cleveland Browns (8-3) in Week 13.