The Los Angeles Chargers could be without both Joey Bosa and Jerry Tillery for their clash with the Pittsburgh Steelers after both were placed on the reserve/COVID-19 list.

Edge rusher Bosa is once again leading the way for the Chargers with 5.5 sacks so far this season, while defensive tackle Tillery has 2.5 sacks and three tackles for loss in 2021.

They would each be significant losses for a Chargers team looking to right the ship after three losses in their past four games and for a defense that ranks 19th in the NFL with 5.59 yards per play allowed.

However, the Chargers pair are not the only players who could miss Sunday's primetime matchup due to being in coronavirus protocol.

Steelers quarterback Ben Roethlisberger was absent for their 16-16 tie with the Detroit Lions after he was placed on the reserve/COVID-19 list, on which he was joined by safety Minkah Fitzpatrick after he tested positive for coronavirus.

Discussing the quarterback position on Tuesday, Steelers coach Mike Tomlin said: "We're going to build our plan around getting Mason [Rudolph, backup QB] ready to play.

"We're going to highlight his talents and skills relative to the opponents that we're intending to play. We're going to build that plan, work that plan. We've got a young offensive unit, and we'll let that lead us throughout the week.

"If we get to a point in the week where Ben has an opportunity to get to a moving train, that's exactly what he'll do. He'll be capable of executing the game plan."

The Chargers (5-4) are a game behind the Kansas City Chiefs in the AFC West, while the Steelers (5-3-1) trail the 6-3 Baltimore Ravens in the AFC North.

Pittsburgh have won four of their past six meetings with the Chargers.