Jack Miller claimed a long-awaited pole position and Aleix Espargaro was left "angry and disappointed" after he could only qualify in ninth at the San Marino Grand Prix.
Ducati rider Miller will start at the front of the grid for the first time in four years after he clocked a quickest lap of one minute and 31.889 seconds on a rainy Saturday in Misano.
Francesco Bagnaia was second-fastest - but will start in fifth after being handed a three-place grid penalty - and Enea Bastianini third, with MotoGP championship leader Fabio Quartararo only eighth.
Espargaro, who trails Quartararo by 32 points, will begin Sunday's race in ninth place and says he was not prepared to take any risks in tricky conditions after a crash at Silverstone last month left him with a fractured heel.
Aprilia Racing's Espargaro knows he will have to take a more aggressive approach on race day.
He said: "My guys said, 'Fabio is [just] in front of you'. But I don't care. This is a very special GP. I want to finish on the podium because it's the home race of Aprilia."
The Spaniard added: "When I left pit lane I felt a mix of angry and disappointed. Because to ride in these conditions is very tricky, very dangerous,
"I touched a white line in the first lap and almost flew [off]. So I tried to focus and make no mistakes, go as fast as possible but without risk. And maybe I had to risk a little bit more because ninth place is not good.
"I didn't want to make a stupid mistake like I did in Silverstone, because there are still a lot of points, a lot of races, a lot of days in front of us. It's just qualifying.
"But obviously if it rains tomorrow, I will have to risk a bit more because you get the points, not today.
"I know that if I want to fight for the championship, I need to finish on the podium. So this is what I'm aiming for."
Andrea Dovizioso will start his final MotoGP race before retiring back in 18th.
PROVISIONAL GRID
1. Jack Miller (Ducati) 1:31.889
2. Enea Bastianini (Gresini Racing) + 0.115
3. Marco Bezzecchi (Mooney VR46 Racing Team) + 0.149
4. Maverick Vinales (Aprilia Racing) + 0.219
5..Francesco Bagnaia (Ducati) + 0.115
6. Johann Zarco (Prima Pramac Racing) + 0.270
7. Luca Marini (Mooney VR46 Racing Team) + 0.327
8. Fabio Quartararo (Monster Energy Yamaha) + 0.347
9. Aleix Espargaro (Aprilia Racing) + 0.678
10. Miguel Oliveira (Red Bull KTM Factory Racing) + 0.876
Hamilton could 'take a holiday' after Sao Paulo disappointment
Lewis Hamilton says he "could happily go and take a holiday" instead of finishing the season after a dismal showing at the Sao Paulo Grand Prix.
He made early exits in both qualifying sessions and started the race at Interlagos from 15th on the grid.
However, unlike Max Verstappen, who impressively won the race having started in 17th, the Brit struggled to mount much of a fight, coming away from the weekend with just one point after finishing in 10th.
His performance was made to look worse as team-mate George Russell had been battling for the lead but narrowly missed out on a podium place as he finished fourth.
Hamilton only has three races left with Mercedes before his move to Ferrari next season, bringing an end to their 12-year partnership.
But he was left frustrated in Brazil, expressing his disappointment with the car.
"We were just slow," Hamilton told Sky Sports F1. "The car was really, really tough. I do really want to say still a big thank you to the guys in the garage. They turned up super early this morning and still did a great job throughout the weekend.
"The team could have won also, so at least one car was behaving a lot better.
"The car is like a plank of wood. It's like no suspension.
"It's bouncing on the tyres everywhere, and you can't get on the power anywhere. It's just the worst ride, I think the worst ride that we've definitely ever had, particularly through corners. It's just so stiff.
"But hopefully we won't have any more bumpy tracks. I think the last three aren't so bumpy. But yeah, I could happily go and take a holiday."
Norris claims Verstappen 'got lucky' in Brazil as title hopes fade
Lando Norris said Max Verstappen benefitted from a rule "no one agrees with" as he won a dramatic Sao Paulo Grand Prix to leave the McLaren's title hopes hanging by a thread.
Verstappen surged to a terrific victory from 17th on the grid in Brazil, with Norris faltering after starting on pole.
Norris and Mercedes' George Russell – who were vying for the lead – both pitted on lap 29, but that strategy backfired as the red flag was shown following a crash involving Franco Colapinto.
With the race suspended, Verstappen was also able to change tires for the restart, negating Norris' advantage from pitting as the world champion raced to a commanding victory.
Norris had cut Verstappen's drivers' championship lead to 44 points by winning Saturday's sprint race but now sits 62 points adrift with just three races of the season remaining.
The Brit refused to hit out at McLaren's strategy after the race, though, putting his struggles down to bad luck.
"I have faith in the team in what they are saying and they have trust in me," he told Sky Sports F1.
"It was just unlucky. I don't care about the hindsight side of things, that's luck for them, nothing more.
"They got lucky on a rule that no one agrees with. Probably they agreed with it today but every driver has disagreed with it in the past.
"Today it benefitted them, it could have benefitted us if we just stayed out, but that's a stupid thing to think of.
"Just a bit unlucky today, nothing more. Of course, disappointing. Max drove well. He got a bit lucky but that's life."
Verstappen 'wanted to destroy' Red Bull garage before Sao Paulo triumph
Max Verstappen revealed he wanted to destroy the Red Bull garage in the hours before he delivered a wet-weather performance for the ages to win the Brazilian Grand Prix.
Verstappen had been left frustrated after Sunday's delayed qualifying session, when a crash by Lance Stroll and subsequent red flag saw him drop out of Q2.
The Dutchman's early exit saw him finish 12th, but a five-place grid penalty for an engine change dropped him to 17th, presenting an opportunity for Lando Norris to take a seismic chunk out of his drivers' championship lead.
But a determined Verstappen then overcame the rain-affected conditions at Interlagos, climbing to P11 on the very first lap before making his charge into the top 10.
His remarkable comeback, which included five consecutive fastest laps, culminated in him passing Alpine’s Esteban Ocon for the lead on lap 43 before romping to victory.
“My emotions were all over the place, from wanting to destroy the garage (after qualifying) to winning the race,” said Verstappen. “It has been a roller coaster.
“It is unbelievable to win here from so far back on the grid. I was expecting to lose points in the championship.
"Now, I just want clean races. But I am not thinking about clinching the title in Vegas.”
A rain-affected race saw several incidents, with Lance Stroll, Alex Albon, Nico Hulkenberg, Franco Colapinto and Carlos Sainz all failing to finish the race.
But Verstappen remained calm in those conditions, snapping his 10-race winless streak, while also becoming the first driver since Kimi Raikkonen at the Japanese Grand Prix in 2005 to emerge victorious after gaining 16 positions.
And the three-time world champion believed his latest win, which was his 62nd in the competition, was his best one to date.
“The rain came, we stayed out, which was very sketchy, and I had to just keep the car on track,” continued Verstappen.
“It was undriveable in the conditions. I felt like I was driving a boat, or a jet-ski.
“There was a lot at stake because I had to be aware of the championship, so for me this is the best one (victory).
"And it is a massive boost for the team because it has been a tough period.”
Verstappen is now 62 points clear of Norris in the drivers' championship with just 86 points remaining, and can win a fourth consecutive drivers' title at the Las Vegas Grand Prix.
However, he insisted that the season was far from over, acknowledging he must remain perfect in the final three races to get over the line after an up and down season.
“Now it’s of course a great result, which if you look a few hours ago, was definitely the other way around, looking like we were going to lose a lot of points," he said.
“So I’m very happy, but still three tough races [to go], so we just need to stay calm and make no mistakes.
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