Tyson Fury will fight Derek Chisora for a third time at Tottenham Hotspur Stadium after a proposed bout with Anthony Joshua fell through.
Talks over a fight between Fury and Joshua fell through, but there will be another all-British heavyweight battle in London.
WBC champion Fury will defend his title against Chisora, who he beat when they first met in 2011 and got the better of again almost eight years ago.
Fury intends to fight Oleksandr Usyk in a bid to become the undisputed world heavyweight champion in the first part of 2023, but next up will be Chisora.
The unbeaten 'Gypsy King' earned a unanimous decision when he fought Chisora for the first time and had his arms raised again after his fellow Englishman was retired by his corner at the end of the 10th round in their rematch at Wembley.
Fury, 34, insisted he had retired after stopping Dillian Whyte in April, but it was no surprise when he made a U-turn to resume his career.
Unbeaten in 33 fights, the 34-year-old will be a strong favourite to beat Chisora for a third time.
The 38-year-old Chisora stopped Kubrat Pulev in his last bout at the O2 Arena in London, taking his record to 33 victories and 12 defeats.
WBA world champion Daniel Dubois will make a first defence of his belt against South African southpaw Kevin Lerena on the undercard.
Frank Warren, Fury's promoter, said: "I am thrilled to be delivering a Tyson Fury world title defence in front of the British fans in London. Tyson clearly conquered America across his trilogy with Deontay Wilder and there is also huge demand to stage his fights from sites across the world.
"Tyson wanted to fight in his home country again this year following his special night at Wembley Stadium in April. This brings us to the magnificent Tottenham Hotspur Stadium and a match against an old rival in Derek Chisora.
"Derek, also a big favourite with British fans, has reinvented himself in recent years and Tyson has long stated his wish to fight him for a third time.
"Tyson can't afford any slip-up in this fight as he has the much-publicised undisputed match-up with Usyk in the new year which we're really looking forward to."