Khris Middleton exited the Milwaukee Bucks' shock 97-92 loss to the Houston Rockets with a left ankle sprain on Sunday.
The 31-year-old All-Star left the game after playing only six minutes where he did not register anything on his statistics line and missed two three-point attempts.
Middleton appeared to roll his ankle during a defensive possession in the first quarter, which left him hobbling before checking out shortly after. He attempted to return in the second quarter but only lasted 90 seconds, before being ruled out.
Jalen Green starred with 30 points for the Rockets, who claimed only their eighth win of the season. Bucks power forward Giannis Antetokounmpo was kept to 16 points, although he brought up his 15,000th career point.
The Milwaukee small forward was playing only his fifth game of the season for the 2021 NBA champions, having been beset by injuries to begin the 2022-23 campaign.
Middleton suffered a playoff-ending Grade 2 MCL sprain against the Chicago Bulls last season, before undergoing offseason wrist surgery, forcing him to miss the Bucks' opening 20 games.
The 2021 NBA champion was averaging 13.8 points, 3.0 rebounds and 5.8 assists in his four games prior to Sunday's injury.
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