The Memphis Grizzlies broke the record for the largest victory in NBA history after humiliating the shorthanded Oklahoma City Thunder 152-79.

Oklahoma City – in the process of a rebuild – were without star Shai Gilgeous-Alexander and Rookie of the Year contender Josh Giddey away to the Grizzlies in Memphis on Thursday.

The Grizzlies, who were without a star of their own in Ja Morant, showed no mercy as they eclipsed the 1991 Cleveland Cavaliers (68 points) for the largest margin of victory in the league.

Cleveland trounced the Miami Heat 148-80 – the Cavaliers went on to reach the Eastern Conference Finals before falling to Michael Jordan and eventual champions the Chicago Bulls.

The Grizzlies, who shot 62.5 per cent from the field while the Thunder managed just 32.9 per cent, were led by Jaren Jackson Jr. and his game-high 27 points.

De'anthony Melton (19), Santi Aldama (18), John Konchar (17), Dillon Brooks (11), Jarrett Culver (11), Xavier Tillman (11), Brandon Clarke (11) and Tyus Jones (10) all had double-digit points for the Grizzlies.

Memphis, who have beaten the Thunder in four straight games for their best winning streak against the franchise since 2013-16, were also 52.8 per cent from three-point range as Jackson made six of his seven attempts from beyond the arc.

Lu Dort was the pick of the Thunder players with 15 points on three-of-eight shooting in 25 minutes – Oklahoma City are now amid an eight-game losing streak.