LeBron James acknowledged "everything went wrong" for the Los Angeles Lakers after their last-gasp 116-115 loss to the Indiana Pacers.

Andrew Nembhard hit a 3-pointer at the buzzer at the Crypto.com Arena to help his side secure victory after fighting back from a 17-point deficit in the fourth quarter.

Defeat marks a second in four matches for the Lakers, who bounced back from their loss to the Phoenix Suns last week with back-to-back wins over the San Antonio Spurs.

James, who posted 21 points in a tough outing, says he and his team-mates ultimately failed to shut the match down and ensure a hungry Pacers side could have no way back.

"[You have] just got to finish the game," he stated. "Everything has to go wrong in order for you to lose a game like that.

"Everything went wrong today. You tip your hat off to Indiana, they kept fighting, they kept pushing."

Coach Darvin Ham took full responsibility for his side's late collapse and questioned how he can fix his team's inability to chase offensive action over the closing stages.

"You get a lead like that and the free-throw line allows you to maintain your lead," he added. "I wish we'd been a lot more aggressive, [and] continued playing with pace.

"That falls on me. I take responsibility for that. Late in the game, [we were] just giving up offensive rebounds. That's been something that has plagued us the last couple of games."

The Lakers next welcome the Portland Trail Blazers on November 30, with the team mired in 13th place in the Western Conference.