Inter Miami will again be without injured superstar Lionel Messi as they look to continue on their course for the Supporters' Shield on Saturday.
Miami will host Chicago Fire with Messi absent, just as he was for the midweek home win over Toronto FC.
"Leo will continue to be evaluated by our medical staff week to week," coach Tata Martino said.
"We will see how he recuperates without taking any type of risk."
Messi suffered an ankle injury while on Copa America duty with Argentina, winning that competition but appearing to hamper Inter's title hopes in the process.
But Martino's men are still well placed to achieve their goals, starting with the regular-season championship.
With victory over Toronto, in which Federico Redondo took centre stage with two goals, Miami became the first team to reach 50 points this season.
They have achieved that feat within 24 games, joining esteemed company. The only six teams to previously tally 50 points inside 24 games have gone on to win the Supporters' Shield.
Next opponents Chicago at least head into this encounter off the back of a win of their own, beating FC Cincinnati on the road on Wednesday.
"When you come on the road and get a result like this, it's a great team effort," said Fire coach Frank Klopas.
"Certain guys are playing really well at the moment, but I still feel that everyone can give more. There's a lot more potential in there with the group.
"That's why this game on Saturday is so massive for us."
PLAYERS TO WATCH
Inter Miami – Federico Redondo
Miami may be missing Messi, but the supporting cast has consistently stepped up this season. They have had four different players score two or more goals in a match, tied for the most in MLS.
The latest of those was Redondo, scoring his first goals in MLS against Toronto. With an assist in that game, too, he will hope that is the start of a strong run of game.
Chicago Fire – Brian Gutierrez
The Fire have had just three goals from substitutes in 2024, yet two of those have been among their past three goals. The latest, their winner against Cincy, saw Gutierrez emerge from the bench to score.
The midfielder will not want that to develop into a consistent theme, however, surely preferring to play from the start. He had done so in each prior game going back to April.
MATCH PREDICTION: INTER MIAMI WIN
Chicago have actually won four of their six games against Miami, including the past three in a row.
But New York City FC are the only team to further extend such a streak against Miami, and their run of five straight victories ended back in 2022. Miami are a very different prospect in 2024.
Their stretch of scoring in 10 consecutive MLS matches is a club record, with their tally of 19 goals across those games showing the task that lies before Chicago – with or without Messi.
OPTA WIN PROBABILITY
Inter Miami – 64.2%
Chicago Fire – 16.7%
Draw – 19.1%