Manchester City will welcome Manchester United to the Etihad Stadium in the Women's Super League.
The match will take place over the weekend of December 10-11, when the Premier League will be on a mid-season break due to the men's World Cup, taking place in Qatar.
It will be the third time the Etihad has hosted a City women's game, after a 2014 clash with Everton and a derby against United.
That match, in September 2019, was won 1-0 by the hosts and drew a then-WSL record crowd of 31,213 supporters.
The news comes on the back of the success of the Women's European Championship, which has taken place in England throughout July.
England take on Germany in Sunday's final at Wembley Stadium, with UEFA anticipating a record crowd at the ground for a match at the Women's Euros.
More than twice as many fans have attended this year's tournament than the previous competition in 2017.