Pep Guardiola conceded Kevin De Bruyne will not feature before the November international break as Manchester City prepare to visit Bournemouth on Saturday.
De Bruyne has not played since mid-September when he was removed against Inter in the Champions League, with a thigh issue his latest injury setback.
The Belgium captain also spent a four-month spell on the sidelines last campaign, and Guardiola revealed bad news on De Bruyne's recovery before Wednesday's disappointing 2-1 defeat to Tottenham in the EFL Cup fourth round.
"I would like to tell you [when he can return], I especially would like to know, but I don't know," said Guardiola.
"He feels better to train, but to go to the level we need for competition he still has pain. Kevin has to feel good to express the huge talent that he has.
"If he doesn't come back as quickly as possible, we will struggle because we cannot sustain it with 14 or 15 players, but it is what it is.
"We need players to come back but it is what it is. Hopefully that can happen after the international break."
City sit a point clear of Liverpool at the top of the Premier League table after their narrow 1-0 win over Southampton, while Bournemouth are 11th after their last-gasp leveller for a 1-1 draw with Aston Villa.
Cherries head coach Andoni Iraola will be expecting a tough test at the Vitality Stadium, though suggested no one can match Villa's left-hand side – not even City.
"I made one sub in the first half for the first time in my career but I have to assume the responsibility because I put Julian [Araujo] in the most difficult game for a right-back that you can find in the Premier League," Iraola said.
"Everyone knows what they’re going to do, but it’s very difficult to defend. The timing and the way they turn the players in the middle, we need to be better in the decision making [going forward]."
PLAYERS TO WATCH
Bournemouth – Antoine Semenyo
Antoine Semenyo has been involved in more Premier League shots following a ball carry than any other player this term (20 – 12 shots, eight chances created).
The Bournemouth midfielder also has three goals and an assist to his name this season in the competition, a tally he will hope to add to on Saturday.
Manchester City – Phil Foden
Talisman Erling Haaland only has one goal in four league matches against Bournemouth, so Phil Foden may be expected to step up here.
Foden has scored in each of his last five appearances against Bournemouth in all competitions (five goals), also providing three assists in these games.
MATCH PREDICTION – MANCHESTER CITY WIN
Guardiola's side are the heavy favourites for this clash, considering they have won all 14 of their Premier League games against Bournemouth.
City have outscored the Cherries 45-7 across their winning run, which is the best 100% record any team has against another in English top-flight history.
Overall, Bournemouth have won none of their 20 league games against Man City (D2 L18), too – it is the most one side has faced another without ever winning in English Football League history.
The Cherries have also lost all 11 of their Premier League games against sides starting the day top of the table, the worst 100% such loss rate in the competition’s history.
Given City are unbeaten in 28 Premier League games in 2024 as well, a feat bettered by only two sides in England's top-flight history, it is hard to imagine anything other than an away win here.
OPTA WIN PROBABILITY
Bournemouth win – 19.8%
Draw – 22.2%
Manchester City win – 57.9%