Liverpool goalkeeper Alisson is expected to be out for at least seven games after sustaining a hamstring injury against Crystal Palace.
The Brazilian went off in the 79th minute of Liverpool's 1-0 victory at Selhurst Park on Saturday and, according to widespread reports, is likely to be sidelined until at least the November international break.
Alisson was replaced by Premier League debutant Vitezslav Jaros against Palace as Caoimhin Kelleher missed that game through illness.
Kelleher deputised earlier in the season when Alisson was sidelined by a different hamstring injury, and is set to do so again, having recovered to join up with the Republic of Ireland national team.
Alisson also immediately pulled out of Brazil's squad for the upcoming World Cup qualifiers before having his scans.
"Alisson is our clear No. 1, the best goalkeeper in the world, so it's a blow when he gets injured for himself and the team," Slot said after the match on Saturday.
"We have a second option that's already good. Caoimhin has already shown that, which is why Caoimhin is the No. 2, and the last time Alisson was injured, I played Caoimhin."
The Reds have made a flying start to the season, winning nine of their 10 matches in all competitions.
However, they will likely have to navigate Premier League matches against Chelsea, Arsenal, Brighton, who they also face in the EFL Cup, and Aston Villa without their usual number one, as well as Champions League meetings with RB Leipzig and Bayer Leverkusen.
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