South Africa have turned to spinners Keshav Maharaj and Simon Harmer as they attempt to secure a 2-0 Test series whitewash of West Indies at the Wanderers.
The Proteas started a new era with Temba Bavuma as captain and Shukri Conrad head coach with an 87-run victory over the Windies at SuperSport Park.
Bavuma has since been dropped from the Twenty20 International team and replaced as skipper by Aiden Markram.
South Africa start the second and final Test in Johannesburg on Wednesday knowing third place in the World Test Championship is there for the taking.
Maharaj and Harmer come into the side along with batter Ryan Rickelton and all-rounder Wiaan Mulder.
Anrich Nortje was ruled out with a groin injury, while Marco Jansen, Senuran Muthusamy and Keegan Petersen also drop out of the team.
The tourists are unchanged despite crumbling to 159 all out in the first Test, Kagiso Rabada doing much of the damage with brilliant figures of 6-50.
Both sides turn their attention to trying to qualify for this year's 50-over World Cup after this match, with South Africa not playing again in the longest format until taking on India in December.
West Indies have won only one of their 16 Tests in South Africa, that coming back in December 2007 and have lost 13 of those matches.
South Africa will be striving to secure a 20th Test win at the Wanderers, a tally they have already reached at Newlands and SuperSport Park.
The Proteas have won both Tests against the Windies at this venue, the last of those triumphs coming in 2003.
Opportunity knocks for Rickelton
Rickelton returns for his fourth Test and Conrad says the 26-year-old left-hander has earned the chance to show he belongs in the middle order.
He said: "Rickelton deserves his crack at it.
"I still feel Keegan has a big role to play in the middle order rather than at the top of the order. I think his best position might be number five going forward in terms of the way he plays.
"But again this Test batting unit is still a work in progress."
Reliable Roach
Kemar Roach has produced the goods time and again for West Indies and he put them in the hunt to win the first Test by taking 5-47 in the second innings, with the Proteas skittled out for only 116.
The paceman has a strike rate of 42.3 against South Africa in Tests, his best against any team in the format.