Jos Buttler succumbed to defeat in his first series as England's full-time T20I captain as India claimed a comfortable 49-run win in the second game at Edgbaston.
India were routine winners in the series opener at the Ageas Bowl on Thursday and their score of 170-8 on Saturday proved far too much for England, whose star-studded batting line-up wilted to 121 all out.
The tourists played with the aggression of a team sensing their chance to claim an unassailable lead in the three-match series, captain Rohit Sharma (31) and Rishabh Pant (26) putting on 49 in under five overs for the opening wicket.
Rohit was removed by 34-year-old debutant Richard Gleeson as Buttler took a stunning diving catch, and the Lancashire bowler then claimed a memorable double-wicket maiden by dismissing Virat Kohli and Pant in successive deliveries.
Hardik Pandya denied Gleeson a hat-trick but he was one of four batters to fall to the excellent Chris Jordan, Hardik departing in the subsequent delivery after Jordan had removed Suryakumar Yadav in a superb 11th over.
India were wobbling on 89-5 at that stage but Ravindra Jadeja counter-attacked with an unbeaten 46 in 29 deliveries to give them something to defend.
They took the task of doing so immediately, Jason Roy edging Bhuvneshwar Kumar behind for a first-ball duck before Buttler was given out to the same bowler on review for just four.
Liam Livingstone (15) also departed cheaply at the hands of Jasprit Bumrah, England continuing to lose wickets in an innings that lacked impetus until Moeen Ali (35 off 21) offered some.
His exit, and those of Jordan and Gleeson, left David Willey (33 not out) protecting the final wicket, which fell when Harshal Patel uprooted Matt Parkinson's stumps.
Bhuvi gets Buttler (again), and then some
Bhuvneshwar dismissed Buttler for a duck in the first game at Southampton and he proved a thorn in the dangerous skipper's side again, the seamer the pick of the bowlers as his 3-15 turned the match firmly in India's favour.
Rohit's streak continues
Rohit has now captained India's T20I side to victory in 14 successive matches. His run of 13 was already a record and with India claiming back-to-back emphatic victories over one of the world's best white-ball sides, they look in excellent shape for the T20 World Cup later in the year.