England have rested Jofra Archer, Sam Curran and Ben Stokes for the one-day series against South Africa, though the trio are included in the Twenty20 squad.
With a potentially busy schedule to come, Rajasthan Royals duo Archer and Stokes, along with Chennai Super Kings all-rounder Curran will get a well-earned break when England take on the Proteas in three 50-over fixtures in early December.
Those games follow on from a trio of T20 internationals between the countries as part of a tour cleared to proceed by the South African government amid the ongoing coronavirus pandemic.
Jos Buttler has also been on duty at the IPL for the Royals yet the wicketkeeper-batsman – England's vice-captain in white-ball cricket - is set to be involved in both formats.
Reece Topley is in the 20 and 50-over squads too, the left-arm paceman having featured in the one-day series against Ireland on home soil earlier this year, his first international appearance in over four years.
There are also places for Lewis Gregory, Liam Livingstone and Olly Stone in a 15-man ODI party, along with Test captain Joe Root and fellow World Cup winner Chris Woakes.
However, Tom Banton has been left out. The batsman is instead on a three-man reserve list alongside Jake Ball and Tom Helm.
England's players and staff are to depart on November 16 and will play two intra-squad practice matches before the first T20 contest on November 27.
All games will be played behind closed doors as the tourists base themselves in a bio-secure bubble in Cape Town. Newlands will be one of the venues used, along with Boland Park in nearby Paarl.
England Twenty20 squad
Eoin Morgan (captain), Moeen Ali, Jofra Archer, Jonathan Bairstow, Sam Billings, Jos Buttler, Sam Curran, Tom Curran, Chris Jordan, Dawid Malan, Adil Rashid, Jason Roy, Ben Stokes, Reece Topley, Mark Wood.
England ODI squad
Eoin Morgan (captain), Moeen Ali, Jonny Bairstow, Sam Billings, Jos Buttler, Tom Curran, Lewis Gregory, Liam Livingstone, Adil Rashid, Joe Root, Jason Roy, Olly Stone, Reece Topley, Chris Woakes, Mark Wood.
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