Kean had not scored since April, but the striker set Juve on their way to victory with an early strike at the Allianz Stadium.
Weston McKennie doubled the Bianconeri's lead with his first Serie A goal of the season, heading home in the second half, and Rabiot added a late double to cap an impressive performance.
That is now back-to-back wins for Massimiliano Allegri's side, who moved up a place to seventh ahead of a must-win Champions League clash at Benfica next week.
Juve started with great intensity and were rewarded just eight minutes in when Filip Kostic whipped in a cross from the left and an unmarked Kean applied the finish from close range.
Kean should have found the net again just after the half-hour mark but headed a McKennie cross wide from six yards out.
The Bianconeri demonstrated the danger they pose from set-pieces to double their lead nine minutes into the second half, McKennie rising to powerfully head Juan Cuadrado's delivery into the roof of the net.
Kean nodded in another sublime Kostic delivery but had his celebrations cut short after straying offside as hungry Juve continued to cause problems.
Juve scored another goal from a Cuadrado corner after 82 minutes, Guglielmo Vicario unable to palm away Rabiot's header before it crossed the line.
The France midfielder then capped a great evening for the Turin giants when Danilo's cross gave him a tap-in at the end.
Meslier, 22, arrived at Elland Road on loan as a 19-year-old in 2019, forcing his way into the starting role as they won the Championship and earned promotion before the club made his deal permanent for £5million.
Since then, he has become the youngest goalkeeper to reach 50 Premier League appearances, and the youngest goalkeeper to tally 10 Premier League clean sheets, earning 11 caps for France's under-21 team in the process.
His exploits – including a season-high nine saves in a 2-1 win against Liverpool in October – have caught the eye of some of Europe's big spenders, and Leeds could be forced into a tough decision sooner rather than later.
TOP STORY – CHAMPIONS LEAGUE HOPEFULS QUEUE UP FOR LEEDS' MESLIER
According to RMC Sport, Bayern view Meslier as a potential long-term successor to Manuel Neuer, although they need the reinforcements as soon as possible due to Neuer's season-ending injury.
Leeds will be in the driver's seat in negotiations, however, with Meslier's contract tying him to the club until 2026.
Meanwhile, Chelsea and Newcastle have been impressed with his performances in the Premier League and would like to add him to their ranks.
It was reported two weeks ago by the Daily Mail that Eduoard Mendy had rejected a six-year contract extension from Chelsea, which would add fuel to this fire, while it is unclear how Newcastle view Nick Pope in their long-term plans.
ROUND-UP
– Fabrizio Romano is reporting Bayern, Newcastle, Liverpooland Paris Saint-Germain will all make a run at signing 21-year-old Borussia Monchengladbach midfielder Manu Koneat the end of the season.
– According to The Times, Brentfordare in the final stages of a £22m move for 21-year-old Freiburg forward Kevin Schade.
– Chelseawill make a late charge for 21-year-old Shakhtar Donetsk winger and Arsenal target Mykhaylo Mudryk, per Fabrizio Romano.
– Calciomercato is reporting 24-year-old Juventus midfielder Weston McKennie has turned down transfers to Bournemouthand Aston Villa in the hope of landing at a bigger club.
– According to The Athletic, Manchester United could still sell right-back Aaron Wan-Bissakathis month despite starting in all three of United's wins since the Premier League season resumed.
Pulisic, who is still regaining full fitness after an ankle injury, entered the blockbuster showdown in the 69th minute and the Chelsea star broke the deadlock five minutes later in Cincinnati.
After being dropped in September for breaching USA's COVID-19 protocol, Weston McKennie scored the decisive second with five minutes remaining before team-mate Miles Robinson was sent off in the final minute of regulation.
The result means USA – who missed the 2018 World Cup – draw level on points with Mexico but move ahead on goal difference at the top of the standings after seven games, having snapped El Tri's unbeaten start in qualifying.
