Wiggins scored a season-high 36 points on 14-of-19 field shooting with a joint career-high eight three-pointers, including three in a row in the third quarter at the Chase Center.
Curry added 30 points, including eight triples, as well as providing 10 assists for Golden State, who have won five of their past six games.
Jordan Poole, who came into the starting line-up for Klay Thompson who was rested, also had 21 points with five three-pointers. Center Kevon Looney had 12 rebounds with nine points.
The Warriors shot 25-of-52 from three-point range as a team, compared to the Rockets who went at 10.7 per cent from beyond the arc, making three-of-28 attempts.
Golden State became the second team in NBA history to make 20 three-pointers in four of five games.
Gobert ejected in Timberwolves defeat
Rudy Gobert was ejected for deliberately tripping Kenrich Williams as the Minnesota Timberwolves were beaten 135-128 by the Oklahoma City Thunder.
The French center was given a flagrant 2 foul and ejected in the second quarter when he tangled with Williams, appearing to sweep a leg out while on the ground, seeing his unbalanced opponent tumble.
Shai Gilgeous-Alexander top scored for OKC with 33 points and six assists, while for the Timberwolves, who were already without Karl-Anthony Towns (calf), D'Angelo Russell and Anthony Edwards scored 27 and 26 points respectively.
Short-handed Bucks down Hornets
The Milwaukee Bucks overcame the absence of Giannis Antetokounmpo due to left knee soreness as they moved to 16-6 with a 105-96 victory over the Charlotte Hornets.
The Bucks, who are second in the Eastern Conference, were also without Khris Middleton and Jrue Holiday but Bobby Portis (20 points, eight rebounds and seven assists) stepped up.
Jordan Nwora added 17 points, while Brook Lopez (14 points including three three-pointers and six rebounds) and Jevon Carter (14 points and six assists) were strong contributors.
Huge expectations surrounded Williamson's long-awaited debut and the number one draft pick did not disappoint at
The 19-year-old, having overcome knee surgery, erupted for 17 straight points in the fourth quarter to finish with a joint team-high 22, plus seven rebounds, through 18 minutes in the New Orleans Pelicans' 121-117 loss to the San Antonio Spurs.
LaMarcus Aldridge led the Spurs with 32 points and 14 rebounds, while DeMar DeRozan added 20 points.
Harden and Westbrook put on their own show in Houston, combining for 55 points as the Rockets topped the Denver Nuggets 121-105.
Fred VanVleet made six of his seven three-point attempts to help the Toronto Raptors prevail 107-95 against the Philadelphia 76ers.
LeBron, Davis drive Lakers
LeBron James dropped 21 points and Anthony Davis had 28 as the Los Angeles Lakers downed the New York Knicks 100-92 at Madison Square Garden.
The win ensured the Lakers bounced back from their heavy loss to the Boston Celtics, who made it two wins on the trot with a 119-95 victory over the Memphis Grizzlies.
There was an overtime thriller in Miami, where Jimmy Butler recorded 24 points, 10 assists and seven rebounds to take the Heat to a 134-129 defeat of the Washington Wizards.
The Los Angeles Clippers' four-game winning streak came to a surprise end against the struggling Atlanta Hawks, who had John Collins to thank for 33 points and 16 rebounds in a 102-95 triumph.
Difficulty for Draymond
Draymond Green struggled on his return from illness as the Golden State Warriors slumped to 129-96 home loss to the Utah Jazz.
The three-time NBA champion played 25 minutes for five points, four rebounds and two assists in the rout.
Zion sends New Orleans into frenzy
Williamson lit up Smoothie King Center, proving a danger from beyond the arc as he went four from four from three-point range.
Wednesday's results
Utah Jazz 129-96 Golden State Warriors
Toronto Raptors 107-95 Philadelphia 76ers
Detroit Pistons 127-106 Sacramento Kings
Oklahoma City Thunder 120-114 Orlando Magic
Los Angeles Lakers 100-92 New York Knicks
Boston Celtics 119-95 Memphis Grizzlies
Miami Heat 134-129 Washington Wizards (OT)
Atlanta Hawks 102-95 Los Angeles Clippers
Chicago Bulls 117-110 Minnesota Timberwolves
Houston Rockets 121-105 Denver Nuggets
Indiana Pacers 112-87 Phoenix Suns
San Antonio Spurs 121-117 New Orleans Pelicans
Lakers at Nets
Kyrie Irving is expected to return from a hamstring problem when the Brooklyn Nets (18-24) host the Lakers (35-9) on Thursday.
