Embiid posted 36 points and 14 rebounds as the 76ers extended their winning streak to four games, while snapping the Clippers' seven-game run on Friday.
After being outscored 20-3 early in the opening quarter, the Kawhi Leonard-less Clippers rallied to take the lead during the closing stages of the final period in Philadelphia.
But the 76ers (39-17) scored seven straight points to move clear 99-94 and they never relinquished the lead, despite the Clippers' efforts.
MVP hopeful Embiid – averaging 34.5 points and 11.0 rebounds over his last four games – became the first 76ers player with at least 36 points and seven rebounds in three consecutive games since Charles Barkley in 1990, while he is the first Philadelphia player with at least 35 points in three straight games since Allen Iverson in 2006.
Having topped Eastern Conference rivals the Brooklyn Nets on Wednesday, it is just the third time in franchise history the 76ers have claimed back-to-back wins against teams 20-plus over .500 after 1966 and 1983.
Paul George put up 37 points and nine rebounds for the Clippers (39-19), who also had a season-high 18 points from Patrick Patterson.
George joined Bob McAdoo, World B. Free and Leonard as the only players in Clippers history to have five straight games with 30-plus points.
The NBA-leading Utah Jazz (42-14) rallied to beat the Indiana Pacers 119-111 after All-Star Donovan Mitchell exited due to an ankle injury.
Mitchell suffered a sprained ankle in the second half, having scored 22 points before leaving in the third quarter.
All-Star team-mates Rudy Gobert (13 points and 23 rebounds) and Mike Conley (10 points and 10 assists) both had double-doubles, while Bojan Bogdanovic put up 24 points.
Randle dazzles to fuel Knicks
Julius Randle's 44 points and 10 rebounds led the New York Knicks past former team the Dallas Mavericks 117-109. Randle became the first Knicks player since Bernard King in 1985 to record 40-plus points, 10-plus rebounds and five-plus assists in a regular-season game. He also became the first Knicks player since Carmelo Anthony in 2013-14 to register multiple 40-point games in a single season.
The San Antonio Spurs lost 107-106 to the Portland Trail Blazers but Dejounte Murray starred with 13 points, 11 rebounds and 10 assists for his third triple-double of the season. The last Spurs player with that many triple-doubles in a season was David Robinson in 1993-94.
MVP frontrunner Nikola Jokic finished with 29 points and 16 rebounds as the Denver Nuggets crushed the lowly Houston Rockets 128-99.
Russell Westbrook inspired the Washington Wizards' 117-115 overtime victory against the New Orleans Pelicans after scoring 10 of their 12 points in the additional period. Former MVP Westbrook tallied 36 points, 15 rebounds and nine assists – finishing just short of a seventh consecutive triple-double. The league's leading scorer Bradley Beal added 30 points.
A Kevin Durant double-double of 25 points and 11 assists guided the Nets to a 130-115 win at home to the Charlotte Hornets. Miles Bridges put up a career-high 33 points for the Hornets.
Jimmy Butler's 30 points and 10 rebounds were not enough after the Miami Heat were upstaged 119-111 by the Minnesota Timberwolves.
Houston humbled
It was a tough outing for the Rockets in Houston. Kevin Porter Jr. headlined their woes after he finished one-for-nine shooting for four points in 32 minutes. He missed all three of his attempts from beyond the arc.
The Orlando Magic lost again, beaten 113-102 by the Toronto Raptors. Orlando's Gary Harris was scoreless from the field. He was 0-for-seven from the field, while failing to make both of his three-point shots.
No-el!
New York's Nerlens Noel made an emphatic block to deny Dorian Finney-Smith.
Friday's results
Utah Jazz 119-111 Indiana Pacers
Detroit Pistons 110-104 Oklahoma City Thunder
Philadelphia 76ers 106-103 Los Angeles Clippers
Washington Wizards 117-115 New Orleans Pelicans (OT)
Brooklyn Nets 130-115 Charlotte Hornets
Toronto Raptors 113-102 Orlando Magic
Memphis Grizzlies 126-115 Chicago Bulls
Denver Nuggets 128-99 Houston Rockets
Minnesota Timberwolves 119-111 Miami Heat
Portland Trail Blazers 107-106 San Antonio Spurs
New York Knicks 117-109 Dallas Mavericks
Jazz at Lakers
Defending champions the Los Angeles Lakers (34-22) will host the high-flying Jazz in a Western Conference showdown at Staples Center on Saturday.