Real Madrid beat Alaves 3-2 on Tuesday to move up to second in LaLiga and have five days to prepare for Sunday's clash with Los Colchoneros, the only team to beat them last season.
Atleti managed a 3-1 win over Los Blancos last September – which remains Madrid's most recent league loss – before dumping them out of the Copa del Rey in January.
The scheduling of Thursday's trip to Celta puts Simeone's men at something of a disadvantage to their rivals, causing them to keep a close eye on players' conditioning.
"We are trying to manage it in the best way possible," Simeone said.
"We have not changed much, trying to make the training sessions based on the players' workloads so that they arrive at the match in the best possible way."
Fixture congestion is an ongoing concern in European football, with the packed calendar being repeatedly criticised amid a spate of injuries to high-profile players, most notably Manchester City midfielder Rodri.
"They are the ones who manage everything, all the rest of us are there to accompany them, to try to manage," Simeone said.
"But the only ones who can create change are the footballers, because they are the ones who play."
Meanwhile, Simeone has backed new strikers Alexander Sorloth and Julian Alvarez to come good, with both players having just one goal apiece so far this term.
"I have no doubt that with time and the partnerships that we will create, they will perform better. It is our job to make them feel better and it is their job to transmit to us those partnerships that are generated in football," Simeone said.
Playing for the first time since football in Spain was suspended due to the coronavirus pandemic, Diego Simeone's side had to settle for a point on the road at San Mames.
Iker Muniain's delightful 37th-minute goal opened the scoring, though Atletico were not behind for long.
Just 129 seconds later, Diego Costa claimed his third goal of the season - and first since October - to bring the visitors level, though the 1-1 result does little to boost Atleti's hopes of a top-four finish.
They sit sixth in the table having drawn 13 of their 28 league games in 2019-20, already the most recorded in a solitary season in the club's history.
Simeone will hope for a more positive outcome when his Champions League quarter-finalists travel to Osasuna on Wednesday.
Atleti went a goal ahead through Julian Alvarez after just 51 seconds, but were unable to add to that before conceding a long-range strike from Luka Sucic with six minutes left.
That goal was one of just five that Simeone's side have conceded in LaLiga this season, which is at least two fewer than any other team, but they failed to have another shot on target after taking the lead.
The visitors' attacking impotence is something Simeone was acutely aware of, while also wanting to be balanced and praise the team's efforts at the opposite end.
"The team found the goal and defended very well, it was a collective effort," Simeone told a press conference.
"We needed to have some counter-attacks with the space we had and do it better than we did, which is also a credit to the opponent.
"I'll stick with the positive things about the defence and we'll continue in the same search, to improve the transitions. There are players who know how to do it."
Sucic's equaliser for Sociedad was an early contender for goal of the season. The Croatian hit the ball first-time from outside the box after a misplaced pass from Atletico midfielder Rodrigo De Paul, which looped over goalkeeper Jan Oblak and into the top corner.
While frustrated with losing their lead, Simeone was of the opinion that goals of such quality are hard to legislate for when it comes to defending.
"I don't think [their goal] was a lack of our concentration, it was a great goal from 35 metres," Simeone said.
"There was a loss of the ball, but they hit us from almost 40 metres and he scored a great goal. We have to improve all the small details, but you can lose a ball because it's part of the game. We have to congratulate him for the great goal he scored."
The 1-1 draw leaves Atletico Madrid third in LaLiga going into the international break, four points behind Real Madrid and seven behind leaders Barcelona.
The result means that, while they have won just one of their last four league games, Atleti maintain their unbeaten start to the season.
"The numbers are good, we are working very well," said Simeone.
"We are in a league where the first team has won eight games out of nine and the second team is [three] points behind. We are working well, growing from the defensive to the offensive."
Joao Felix scored one and assisted another as LaLiga leaders Atletico beat Valencia 3-1 on Sunday, but it was the club-record signing's first league start of 2021.
The Portugal forward had not scored in LaLiga since November 7, costing him his place in Simeone's starting XI.
Even against Valencia, having attempted three shots and made two key passes, Joao Felix was withdrawn after 62 minutes for Angel Correa.
It was a move that paid off as Correa added the third goal - Joao Felix having set Luis Suarez clear for the crucial second - and Simeone hailed his changing frontline as evidence of competition in the Atleti squad.
"Joao Felix is an extraordinary player," Simeone said. "We always need him.
"The competition is high, beautiful, good. They are all eager to play and we will have to give the time we can for the good of the team.
"[Joao Felix] is growing, as he has been doing since he arrived. He is important and everything he gives us helps us."
In maintaining his unbeaten home record against Valencia, which now stands at six wins and four draws from 10 LaLiga matches, Simeone took Atleti seven points clear at the top of the table with a game in hand over second-placed Real Madrid.
The Rojiblancos coach was not interested in assessing the state of play at the summit, though, instead turning attention to Atleti's next test on Sunday.
"Cadiz, nothing more," Simeone replied when asked about the advantage over Madrid and Barcelona, who are a further three points back from Los Blancos.
Madrid welcome neighbours and LaLiga leaders Atletico to Estadio Alfredo Di Stefano, with Simeone's men holding a one-point advantage over Real Sociedad atop the table.
Defending champions Madrid are six points off the pace and while Atletico have only lost one of their last eight derbies in LaLiga, keeping seven clean sheets, Simeone is wary of an experienced Los Blancos side.
"It is a nice game where there are fantastic football players in both teams. Real Madrid has been competing at the highest level for many years," Simeone told reporters.
"As I said yesterday [Thursday], I feel admiration for our opponent and the players they have. They are maintaining a great level despite the amount of time they have been on top. Some of them they are 33, 34 or 35 and they are still young in their minds.
"That's the most important thing. And this is something to admire, even if it is an historic rival for us.
"We are keeping our way, leading the game in the areas where we can hurt them. And there, we will be playing a game which surely will be beautiful."
Atletico have failed to win in their last eight LaLiga games against Madrid – drawing five games and losing three – after winning four of the previous six against their rivals in the competition.
But Atletico have won their last seven LaLiga games, keeping a clean sheet in six matches – last winning eight or more in a row in the competition in March-April 2014.
After winning his first LaLiga game as coach against Atletico's Simeone in February 2016), Madrid boss Zinedine Zidane is unbeaten in his last six games against the Argentinian in the league.
As for Atletico forward Luis Suarez, he has scored nine goals in his 11 LaLiga games against Madrid but has failed to score in his last two, his longest run without scoring against the Spanish powerhouse in the competition.
"Every footballer has ups and down," Simeone said of Suarez. "We shouldn't forget Luis has gone through coronavirus. I think his last game was in Ecuador… around twenty days with no competition. So, it is normal he needs time to get back to his best.
"Luis is a very important player for us. A striker who has goals in his DNA. Saturday is an important game for him and for the team. So, hopefully he can give his best during the time he is on the pitch."
The duo were the star performers for the Rojiblancos as they helped steer their side to a 3-0 win on Monday evening, with the former bagging all three assists and the latter netting a brace.
It marked an impressive return to the field in Atletico colours for both, with Felix having spent the end of last season sidelined through injury, and Morata spending the prior two campaigns on loan at Juventus.
Felix, in particular, delivered an assured performance that showcased his growth for Simeone, who said the Portuguese star's talent helps his game speak for itself.
"He looks more mature, stronger," he stated. "He showed last season until he had to leave due to injury. He is growing, [he] shows maturity, [he] sees more than the others.
"You don't have to force anything. Things come naturally and he has worked to get to this point. He has talent, he has a goal, and hopefully he can support everything he says here on the field."
Morata famously signed for Atletico following a loan move from Chelsea in 2020, only to promptly be loaned back out to former club Juventus for the subsequent two seasons.
The subject of his future remains up in the air beyond the end of the transfer window, and Simeone admitted he does not know what the next steps will be for the Spanish international, though he hopes for the star to remain.
"I am not the owner of the club, I am the coach," he added. "He is doing very well, working in an extraordinary way, and we hope that Morata will continue with us.
"I think that all footballers have to have confidence to do important things. He came with humility, desire to work, without demanding anything, striving to get to this shape and that is what we want to see."
Atletico took the lead within two minutes when in-form forward Joao Felix capitalised on a goalkeeping error to score, registering his sixth goal involvement in six league games.
Yet Cadiz drew level when Alvaro Negredo netted a superb header just before half-time.
Despite Diego Simeone's men registering only six shots to Cadiz's 14 throughout the contest, as well as tallying a mere 0.60 expected goals (xG), De Paul swept home his first LaLiga goal after 68 minutes to send last season's champions third in the table.
Javi Serrano received the fastest red card issued to a LaLiga substitute this season, being dismissed four minutes and 49 seconds after entering the fray late on, but Atletico held out for a crucial victory, and De Paul was delighted with the team's character on a difficult evening.
"We pulled it off," the Argentina midfielder told LaLiga TV. "We had the character to do it. We leave happy and wanting to continue improving.
"I don't know if we relaxed with the 1-0. The game took on a different dynamic, Cadiz had to come looking for us. We were well placed but we failed in our passes.
"The important thing is the attitude, the desire and that is the fourth victory in a row.
"Luckily the goal came. It's nice to score when you help the team."
The Spanish champions have lost on their last two away trips to face English sides in the Champions League, at Chelsea in 2020-21 and Liverpool this season without scoring a goal in either, but De Paul hoped the team's strong domestic form would serve them well at Old Trafford.
"That confidence has to serve us for the match in Manchester," he said. "Hopefully we can have a great match there."
Atletico boss Simeone, meanwhile, was not happy with his side's limp performance, but emphasised the importance of the result as Atletico battle for a top-four finish and a return to the Champions League next season.
"Cadiz controlled the game, not having clear scoring situations, but neither did we, neither pressing, nor winning the second ball, nor making quick transitions", Simeone said.
"[It was] a flat, flat, slow game, without intensity, without recovery, without quick transitions, without winning the second ball. [It was] a little better in the second half, but we need to get back to the situations we've been showing in these last few games.
"In this final stretch of the championship, if I always say that the most important thing is to win, [it is] much more so now."
Atletico now possess a five-point cushion over fifth-placed Real Betis in LaLiga, although Betis possess a game in hand.
A clutch of chances had been spurned by the time Vitolo came off the bench to replace Marcos Llorente with 17 minutes remaining, with Joao Felix and Alvaro Morata going close.
When the breakthrough came in the 81st minute it was dramatic, Vitolo heading at goal after a corner from the left reached him at the far post.
Valladolid defender Kiko Olivas felt he had nodded it off the line after diving spectacularly to reach the ball, but replays showed it was six inches over and Atletico moved back up to third.
The visitors withstood an early spell of pressure and almost took the lead in stunning fashion when Julian Alvarez's strike from distance cannoned off the crossbar.
But Diego Simeone's side found themselves a goal down in the 35th minute when Isi Palazon turned home Raul de Tomas' cross after good work from Jorge de Frutos.
However, parity was restored four minutes after the break when Conor Gallagher struck beyond Augusto Batalla from the edge of the area to net his second goal in as many games for his new club.
Atletico continued to push for a winner, with Alvarez and Angel Correa going close, but Rayo Vallecano were able to hold firm for the closing exchanges.
The result leaves Simeone's side in fourth place, six points behind league leaders Barcelona who thumped Villarreal 5-1 earlier in the day.
Data Debrief: Gallagher embracing advanced role
Having only scored 10 goals in 90 appearances for Chelsea, Gallagher is flourishing under Simeone's stewardship in Spain.
During the contest, only Koke and Alvarez (both 14) made more passes into the final third than Gallagher (11), with his strike coming from an expected goals (xG) total of just 0.06.
But the England international did not neglect his defensive responsibilities. Gallagher won more tackles (four) than anyone on the pitch, while also winning three fouls.
The home fans threw objects onto the pitch near Thibaut Courtois in the 69th minute, forcing a stop to proceedings as the trouble was dealt with.
Shortly before that, Eder Militao had opened the scoring for the visitors, with his rifled effort taking a deflection past Jan Oblak into the back of the net 64 minutes in.
The game was stopped for around 20 minutes, and when the players returned to the pitch, Atletico piled the pressure on.
They eventually levelled the score in the 95th minute, with substitute Correa rounding Courtois to roll it into an empty net, and the goal, which was initially ruled offside, was given following a VAR review.
Diego Llorente was then sent off four minutes later, sliding in with a heavy challenge on Fran Garcia, with VAR upgrading his yellow card to a red.
Real Madrid are second in the standings on 18 points, three behind Barcelona, but two ahead of Atletico in third after eight games.
Data Debrief: Sharing the spoils
For the most part, the Madrid derby was a cagey affair, with neither side creating too much of note in the opening exchanges, but they both ramped up the pressure after the break.
Vinicius Junior's assist for the opener was his fifth in all competitions so far this season, the joint-most of any player across the top five European leagues.
But you can never count Atletico out - they have scored five goals in the final 15 minutes of the second half so far this season, with no team in LaLiga netting more.
All in all, it was a memorable tie, even more so for Antoine Griezmann, who was making his 500th LaLiga appearance, becoming the 14th player to hit the milestone in the competition's history.
Lille have now beaten a second Madrid team in consecutive matchdays after also stunning holders Real Madrid 1-0 earlier in October.
Atletico took the lead in the eighth minute with Julian Alvarez intercepting a weak back-pass from Lille defender Ousmane Toure and slotting in for the lead.
There was more bad news for Lille when they had to take off injured midfielder Remy Cabella in the 16th minute, bringing in Edon Zhegrova, but they avoided further pain as Alexander Sorloth wasted three golden scoring opportunities in the first half.
The visitors punished Atleti by leveling in the 61st minute as Zhegrova whipped in a superb left-footed shot into the top far corner.
Lille then scored again to seal their comeback courtesy of a 74th-minute penalty by David, who had also scored the winner against Real.
The Canadian then added another goal with a deflected effort in the 89th to lift Lille to six points. Atletico, meanwhile, are on three with just one win from their three games so far.
Data Debrief: Lille put another Madrid side to the sword
Three weeks on from defeating Real Madrid in one of the most famous results in their history, Lille followed it up with three more points against Atletico.
In doing so, they are just the third team in Champions League history to beat those two sides in a single edition of the competition, along with Chelsea (2020/21) and Manchester City (2021/22).
David was the hero after his 65th-minute introduction, netting his fifth and sixth goals in this season's competition - at least twice as many as any other Lille player.
Lille have now beaten a second Madrid team in consecutive matchdays after also stunning holders Real Madrid 1-0 earlier in October.
Atletico took the lead in the eighth minute with Julian Alvarez intercepting a weak back-pass from Lille defender Ousmane Toure and slotting in for the lead.
There was more bad news for Lille when they had to take off injured midfielder Remy Cabella in the 16th minute, bringing in Edon Zhegrova, but they avoided further pain as Alexander Sorloth wasted three golden scoring opportunities in the first half.
The visitors punished Atleti by leveling in the 61st minute as Zhegrova whipped in a superb left-footed shot into the top far corner.
Lille then scored again to seal their comeback courtesy of a 74th-minute penalty by David, who had also scored the winner against Real.
The Canadian then added another goal with a deflected effort in the 89th to lift Lille to six points. Atletico, meanwhile, are on three with just one win from their three games so far.
Data Debrief: Lille put another Madrid side to the sword
Three weeks on from defeating Real Madrid in one of the most famous results in their history, Lille followed it up with three more points against Atletico.
In doing so, they are just the third team in Champions League history to beat those two sides in a single edition of the competition, along with Chelsea (2020/21) and Manchester City (2021/22).
David was the hero after his 65th-minute introduction, netting his fifth and sixth goals in this season's competition - at least twice as many as any other Lille player.
There were three red cards in the contest, with Elche captain Gonzalo Verdu dismissed late in the first half before Mario Hermoso was sent off for the hosts early in the second.
Joao Felix and Morata struck after that to seal the win, with Elche substitute Domingos Quina also seeing red in stoppage time as the Rojiblancos eased to three points at the Metropolitano.
After a three-game winless streak ahead of the mid-season World Cup break checked their momentum, Diego Simeone's side will be relieved to get back to winning ways.
Chances were few and far between for Atletico in the first half, and it was telling that even Verdu's VAR-assisted dismissal for an off-the-ball foul on Morata just before the break did little to lift them.
Their man advantage was temporary too, with Hermoso handed his marching orders after back-to-back bookings, the second for a reckless foul on Helibelton Palacios after the interval.
But Joao Felix's close-range header, turning in Antoine Griezmann's short rebound cross, gave a fresh lease of life to the hosts and allowed them to play with greater freedom.
That translated into a second goal, this time after Morata exquisitely dribbled in off the right wing to turn the defence inside out in the 74th minute, and effectively put the game to bed with a deflected effort that lopped over Edgar Badia and in.
Elche's efforts to respond saw their discipline slip once again, with late substitute Quina also dismissed for a quick double booking, the second after a clumsy foul on Morata, as Atletico cruised through to victory.
Atletico's sixth win of the season moved them up to third in LaLiga after 12 games, while Las Palmas remain inside the bottom three in the Spanish top-flight.
Diego Simeone's side started strongly at the Metropolitano Stadium, with Antoine Griezmann and Julian Alvarez going closest to netting the first goal.
But their dominant opening was rewarded in the 37th minute when Simeone was sent through by Nahuel Molina, with the Argentine slotting past Jasper Cillessen for his first LaLiga goal.
The hosts threatened to extend their advantage before the break, but Samuel Lino and Pablo Barrios saw their efforts unable to trouble Cillessen.
Simeone's side continued to dominate proceedings, finally getting the goal their display merited seven minutes from time, with Sorloth beating the offside trap before curling the ball home to seal the victory.
Data Debrief: Like father, like son
Simeone followed in his father's footsteps against with his goal against Las Palmas, netting his first strike for Atletico in his eighth LaLiga match, almost 20 years after his father and manager, Diego, scored his last goal for the club against Real Madrid.
But Sorloth also impressed. Since his arrival in LaLiga in the 2021-22 season, only Karim Benzema (46), Vinicius Junior (47) and Robert Lewandowski (56) have scored more goals than the Norwegian (43, level with Iago Aspas).
Atletico have now won nine of their last 11 matches against Las Palmas in LaLiga (L1), keeping a clean sheet in nine of those games.
Atletico's sixth win of the season moved them up to third in LaLiga after 12 games, while Las Palmas remain inside the bottom three in the Spanish top-flight.
Diego Simeone's side started strongly at the Metropolitano Stadium, with Antoine Griezmann and Julian Alvarez going closest to netting the first goal.
But their dominant opening was rewarded in the 37th minute when Simeone was sent through by Nahuel Molina, with the Argentine slotting past Jasper Cillessen for his first LaLiga goal.
The hosts threatened to extend their advantage before the break, but Samuel Lino and Pablo Barrios saw their efforts unable to trouble Cillessen.
Simeone's side continued to dominate proceedings, finally getting the goal their display merited seven minutes from time, with Sorloth beating the offside trap before curling the ball home to seal the victory.
Data Debrief: Like father, like son
Simeone followed in his father's footsteps against Las Palmas, netting his first goal for Atletico in his eighth LaLiga match, almost 20 years after his father and manager, Diego, scored his maiden goal for the club in his ninth game in the competition against Real Madrid.
But Sorloth also impressed. Since his arrival in LaLiga in the 2021-22 season, only Karim Benzema (46), Vinicius Junior (47) and Robert Lewandowski (56) have scored more goals than the Norwegian (43, level with Iago Aspas).
Atletico have now won nine of their last 11 matches against Las Palmas in LaLiga (L1), keeping a clean sheet in nine of those games.
The German side took a shock lead in the fourth minute thanks to a header by striker Benjamin Sesko, capping a quick counter-attack.
However, Antoine Griezmann struck a fine volley into the top corner in the 28th minute to level the scores.
Atletico dominated the match with 20 attempts on goal in total, but it wasn't until the 90th minute that they finally managed to find the winner, with Gimenez heading in a cross from Griezmann.
Data debrief: Griezmann inspires Atleti again
Griezmann proved once again to be the talisman for Atletico Madrid, with a goal and an assist, three chances created, winning 100% of his aerial duels and recovering the ball eight times.
After netting Atletico's first-half equaliser in this match, 26 of Griezmann’s 37 goals in the Champions League have now come on home soil, moving him level for home goals in the competition with Sergio Aguero and Alessandro Del Piero.
Leipzig have now failed to win in their last three games in Champions League, which is their longest winless streak in the competition since a run of six games from February to November 2021.
Marcos Llorente and Samuel Lino went close in the first half before Atletico took the lead in the 39th minute, new signing Gallagher finishing into the bottom corner after latching onto a delightful pass from Rodrigo De Paul.
Valencia fought hard for an equaliser, with Javi Guerra's long-range effort going wide, but they were unable to prevent Antoine Griezmann from making it 2-0 after Lino's header fell into his path nine minutes after the break.
Another new recruit, Alvarez, put the icing on the cake with his first goal in the Spanish top flight since arriving from Manchester City, when he slotted home Rodrigo Riquelme's cross in the 93rd minute.
Atletico, who are still unbeaten this season, moved into second place, level on 11 points with Real Madrid and four behind leaders Barcelona.
Data Debrief: New boys off the mark
Gallagher's opener made him the third-youngest Englishman to net in LaLiga this century, at the age of 24 years and 222 days.
Only Jude Bellingham (20 years and 44 days) and Mason Greenwood (22 years, seven days), both in 2023, have done so at a younger age.
He wasn't the only new recruit to impress on Sunday, though.
Alvarez's goal made him the 14th Argentinian player to score for Atleti since the turn of the century, with no other foreign nation supplying as many unique goalscorers for Los Colchoneros in that time.
Diego Simeone's side struck three times in the final 21 minutes to extend their unbeaten start to the LaLiga season, while maintaining the pressure on pace setters Barcelona and Real Madrid.
Leganes had only scored once in eight previous top-flight meetings with Atletico, but broke the deadlock in the 34th minute through Yvan Neyou's brilliant strike into the top corner.
The hosts brought themselves level in the 69th minute, when Sorloth back-heeled in Axel Witsel's cross for his first home league goal since arriving from Villarreal.
Antoine Griezmann completed the turnaround with 11 minutes remaining, as his lofted cross crept in at Marko Dmitrovic's far post.
And Sorloth sealed the victory deep into stoppage time, turning home a rebound after Julian Alvarez's initial effort fell kindly for him.
Data Debrief: Another late show from Atletico
Atletico won after trailing at half-time in a LaLiga game for the first time since doing so against Cadiz just over a year ago, having failed to win in their nine previous such matches.
Sorloth's double proved crucial in the hosts' fightback. The former Villarreal forward's first Atleti goals on home soil took his LaLiga tally for 2024 to 20, with only Barcelona's Robert Lewandowski (21) netting more during the calendar year.
Los Rojiblancos' late turnaround means they have won a league-high seven points from goals scored in the last 15 minutes of their matches this season.
The Spanish side have now won each of their last 10 matches in all competitions as they closed in on the automatic qualification spots.
Julian Alvarez opened the scoring for Atletico with a well-taken strike, curling his shot into the top-right corner past Dominik Takac after just 16 minutes.
Slovan almost caused an upset against the run of play shortly after as Tigran Barseghyan caught out Jan Oblak with a floated effort, but struck the top of the crossbar.
Atletico continued to dominate in the first half and got their reward as Griezmann scored for the fifth successive match with a thumping header just before the break.
The visitors briefly got back into the match to pull it back to 2-1 when Davis Strelec earned a penalty and converted himself from 12 yards, but Griezmann restored the two-goal cushion six minutes later with a simple finish at the near post.
Atletico moved up to 10th with 12 points from six matches, while Slovan are rooted to the bottom of the 36-team table having lost all six games and they cannot make the playoffs.
Data Debrief: Atletico's winning run goes on
After a poor start to the Champions League that saw Atletico lose two of their first three games, they have since turned things around by winning the following three in the competition.
But it is not just in Europe where they are flying high as they have now scored 30 goals during their 10-match winning run.
Since the start of last season, no team have won more home matches in the Champions League than Atletico (W7 L1), and have scored at least two goals in all of those home victories.
Among teams who have scored 100+ goals in the Champions League, only Lionel Messi (20.4% for Barcelona) has scored a higher percentage of a club's goals in the competition than Griezmann has for Atletico (19% - 36 of 189).
The result moved Diego Simeone's side up to third in the standings after 16 games so far, a point behind Real Madrid and three adrift of leaders Barcelona.
After Griezmann had rattled the crossbar early on, Atletico took the lead in the 10th minute through Rodrigo De Paul's fierce effort into the roof of Alvaro Fernandez's net.
But Sevilla responded just two minutes later, with Dodi Lukebakio levelling the scores before Isaac Romero rounded off a quick counter-attack with a fine finish.
Juanlu Sanchez then put the visitors two goals in front in the 57th minute, tucking the ball past Jan Oblak after being picked out by the influential Kike Salas.
But Atletico's comeback started five minutes later as Griezmann reduced the deficit before substitute Samuel Lino's effort from distance restored parity in the capital.
However, more drama would unfold after Griezmann gathered Lino's pass, firing the ball in off the crossbar in the fourth minute of second half stoppage time.
Data Debrief: The late late show
Atletico laid down a huge marker of their title credentials this season on Sunday, with their powers of recovery on show with their late turnaround on home soil.
And the hosts were worthy of their dramatic triumph, having registered an expected goals (xG) of 2.11 from their 14 shots compared to Sevilla's 0.39 from their four efforts.
Griezmann proved to be Atletico's saviour once again, with the Frenchman putting on an impressive display in the process. He registered the most shots on target (three) and touches in the opposition box (nine) for his side, while also accumulating a team-high xG tally of 0.76.
