Clark – aged 17 years, four months and 18 days – became the youngest player to score in his first two MLS appearances on Wednesday, per Opta.
Hours after joining the Red Bulls, Clark capped his debut with a goal in Saturday's 1-0 win over Atlanta United.
Clark became the youngest player to score his maiden goal for the Red Bulls since Jozy Altidore in 2006.
He continued where he left off against Toronto, netting the equaliser with 13 minutes remaining midweek.
Following Alejandro Pozuelo's 23rd-minute penalty, Clark earned the visiting Red Bulls a point by firing a shot into the top corner of the net from outside the box.
The Red Bulls are seventh in the Eastern Conference, while Toronto – already play-off bound – remain top through 18 games.
Elsewhere, reigning Supporters' Shield holders Los Angeles FC and struggling LA Galaxy were beaten.
Lucas Cavallini's brace lifted Vancouver Whitecaps to a 2-1 victory against fourth-placed LAFC.
Canada international Cavallini has now scored in back-to-back games after finding the net just twice in his first 11 MLS matches for the Whitecaps, who climbed up to eighth in the standings and in the play-off positions.
As for the Western Conference's bottom side – the Galaxy – they were swept aside 4-0 by San Jose Earthquakes in the Cali Clasico.
Former Manchester United and Real Madrid striker Javier Hernandez was substituted early in the second half, with the Galaxy only managing four goals in the 652 minutes 'Chicharito' has been on the pitch this season.
It was a sixth consecutive defeat for the slumping Galaxy as the Earthquakes moved within a point of LAFC in the west.
Wednesday's scheduled Minnesota United-Chicago Fire fixture was postponed due to a suspected coronavirus case among Minnesota's team delegation.
In other results, New England Revolution edged Montreal Impact 3-2, FC Cincinnati were 2-1 winners over Columbus Crew, Orlando City and New York City drew 1-1, Atlanta saved a 1-1 draw at Inter Miami, Sporting Kansas City fell 1-0 to Dallas, DC United and Philadelphia Union shared the points in a four-goal clash, Real Salt Lake trumped Portland Timbers 2-1 and Nashville accounted for Houston Dynamo 3-1.
Adam Buksa's goal after 70 minutes kept New England atop the east with a 1-0 win over FC Cincinnati.
The Revolution are now five points clear of second-placed Orlando City after the Lions' 2-1 defeat to New York Red Bulls.
Ten-man New York City FC stunned Los Angeles FC 2-1 on Ismael Tajouri-Shradi's 90th minute goal after Jesus Medina had equalised 20 minutes earlier.
Trailing 2-0 heading into the final 10 minutes, Nashville saw Hany Mukhtar score in the 80th and 83rd minutes to lift the visitors to a 2-2 draw with Atlanta United.
Mason Toye's 87th-minute strike gave Montreal a 1-0 victory over Chicago Fire, while Columbus Crew held on to beat Toronto FC 2-1 on early goals by Luis Diaz and Gyasi Zardes.
Sporting Kansas City rallied from a first-half deficiit to defeat Houston Dynamo 3-2 as Gianluca Busio, who turned 19 on Friday, started the comeback with an outrageous free kick.
Ola Kamara's brace led the way as D.C. United rolled 3-0 to keep Inter Miami winless at home.
A late own goal from Tanner Beason of the San Jose Earthquakes gave LA Galaxy a 1-0 win.
Niko Hansen's 78th-minute tally salvaged a 1-1 draw for Minnesota United against Real Salt Lake after Damir Kreilach opened the scoring in the 13th minute.
Colorado Rapids got goals from Keegan Rosenberry, Tanner Tessmann and Michael Barrios to ease past last-place FC Dallas 3-0.
Thomas McNamara's goal in the 88th minute gave New England a 3-2 victory over New York City FC, just three minutes after Ismael Tajouri-Shradi had equalised for the home side.
Gustavo Bou and Jon Bell also found the net for the Revolution, who are five points clear of Orlando City in the Eastern Conference.
Out west, goals four minutes on either side of half-time from Yeimar Gomez and Raul Ruidiaz lifted unbeaten Seattle to a 2-1 win at LA Galaxy.
Orlando City got early goals from Tesho Akindele and Nani before Junior Urso netted in the 84th minute to defeat Toronto FC 3-2.
Columbus Crew got a brace from Gyasi Zardes to beat Chicago Fire 2-0, while Colorado Rapids won by the same scoreline at FC Cincinnati as Diego Rubio and Jonathan Lewis found the scoresheet.
Ola Kamara's 72nd-minute penalty was the difference for D.C. United in a 1-0 win over Inter Miami, who saw Gregore and Ryan Shawcross shown red cards.
Portland Timbers defeated Sporting Kansas City 2-1 on first-half goals from Dairon Asprilla and Marvin Loria.
Ricardo Pepi's 68th-minute equaliser gave FC Dallas a 1-1 draw with Minnesota United after Franco Fragapane had given the visitors a first-half lead, while Austin FC and San Jose Earthquakes finished in a 0-0 draw.
Houston Dynamo earned a point on the road in a 1-1 draw against Los Angeles FC as Maximiliano Urruti matched Jose Cifuentes' second-half goal.
Cristian Roldan inspired Seattle to a 3-1 win over the Galaxy in California.
Roldan opened the scoring in the 12th minute, completing a fine team move by getting on the end of a Jordan Morris cross.
Morris doubled the lead seven minutes before half-time, finishing after a lovely pass from Nicolas Lodeiro.
Roldan produced a clinical finish from a Joao Paulo pass to make it 3-0 just after the hour-mark, with Seattle winning despite Sebastian Lletget's late goal for the LA Galaxy.
It marked Roldan's third multi-goal game in MLS, and two have come against the Galaxy.
Seattle are top of the Western Conference, equal on points with the Portland Timbers, who recorded a 1-0 win over the Vancouver Whitecaps.
After joining Inter Miami following his Juventus release, Higuain had a tough debut in a 3-0 loss to the Philadelphia Union.
Higuain hit the outside of the post with a bicycle kick and later put a penalty over the crossbar.
Anthony Fontana, Ilsinho and Brenden Aaronson scored for Philadelphia, who are second in the Eastern Conference.
Higuain, meanwhile, has failed to convert his past four penalties in all competitions.
Eastern Conference leaders Columbus Crew fell to a 3-1 loss to Toronto.
The New York Red Bulls thrashed the Montreal Impact 4-1, the New England Revolution beat DC United 2-0 and Chicago Fire overcame Atlanta United 2-0.
Minnesota United played out a goalless draw with Real Salt Lake, while Dallas' clash with Orlando City also finished 0-0.
The San Jose Earthquakes ended a nine-game winless run by beating Los Angeles FC 2-1.
Trailing 4-2 heading into the 90th minute, former Manchester United and Italy forward Giuseppe Rossi reduced the deficit for RSL in Portland – his first MLS goal.
And Sam Johnson completed the stunning comeback against the MLS is Back Tournament champions in the fourth minute of stoppage time.
In a wild showdown, the Timbers opened the scoring through Diego Chara in the sixth minute before RSL's Corey Baird restored parity 13 minutes later, but Jaroslaw Niezgoda's effort within two minutes ensured Portland led 2-1 at half-time.
After Real Salt Lake equalised again, this time courtesy of Damir Kreilach three minutes into the second half, Portland took control of the contest.
Sebastian Blanco's stunning effort with 20 minutes remaining and Felipe Mora's effort five minutes from time seemingly had the Timbers on track before the hosts capitulated.
The Timbers are fourth in the Western Conference, a point above RSL after seven matches.
LA Galaxy beat San Jose Earthquakes for the first time since 2018 thanks to their 3-2 triumph in the California Clasico.
Sebastian Lletget's 82nd-minute goal settled the five-goal thriller after the Earthquakes had led 1-0 and 2-1 against the Galaxy.
After posting just their second win in the regular season, the Galaxy are ninth in the west, while the Earthquakes are eighth.
In other results, Philadelphia Union crushed DC United 4-1, New York City accounted for Chicago Fire 3-1, Dallas defeated Minnesota United by the same scoreline and Orlando City also topped Atlanta United 3-1.
FC Cincinnati played out a 0-0 draw with Columbus Crew, New York Red Bulls drew 1-1 against New England Revolution, while Western Conference leaders Sporting Kansas City were held to a 1-1 draw by Colorado Rapids.
Alan Pulido, Luis Martins and Daniel Salloi all scored within 16 minutes as KC raced to a 3-0 lead. Salloi's classy volley took his tally to nine goals this MLS season.
Israeli midfielder Gadi Kinda added a fourth in the 58th minute with Graham Zusi getting his second assist, before LAFC got a consolation from Danny Musovski.
The win lifted Sporting KC past Seattle Sounders who conceded in the 90th minute to draw 1-1 at home with Dallas.
Fredy Montero had put the Sounders ahead in the 72nd minute with a set-piece header but Dallas equalised from Franco Jara's 90th-minute close-range strike.
Sporting KC are ahead of Seattle on goal difference, with both sides having 33 points, although the leaders have a game in hand.
LA Galaxy are third following a 1-0 victory over Real Salt Lake, secured by Efrain Alvarez's cool 53rd-minute winner.
Eastern Conference leaders New England extended their unbeaten run to five games with a 0-0 draw against Nashville, who slip to fourth despite the result.
The draw also extends Nashville's undefeated streak to nine games.
Former England international Kieran Gibbs netted a 66th-minute equaliser to earn Inter Miami a 1-1 draw away to fellow Florida outfit Orlando City. The goal was Gibbs' first in the MLS.
Philadelphia Union ended their three-game winless run with a 3-0 victory over Toronto after three first-half strikes.
Ola Kamara and Yordy Reyna both netted doubles as DC United won 4-2 over Columbus Crew.
Tomas Pochettino scored a first-half brace as struggling Austin won 3-2 over Houston Dynamo.
Chicago Fire and 10-man New York City played out a goalless draw, while New York Red Bulls and Cincinnati also ended 0-0 and Portland Timbers drew 1-1 with San Jose Earthquakes.
Sergio Santos netted three times as Philadelphia crushed Toronto 5-0 at Subaru Park on Saturday.
The result equalled the Union's biggest ever win and Toronto's largest defeat, as per Opta.
Philadelphia needed until the 27th minute to get going, Sergio Santos heading in a wonderful cross from Kai Wagner.
Just six minutes later and the hosts doubled their lead, Mark McKenzie heading in from close range after a corner.
Jamiro scored a spectacular third for Eastern Conference leaders Philadelphia in the 56th minute, his 20-yard effort going in off the underside of the crossbar.
Sergio Santos put away two more to complete his hat-trick – the fourth in the Union's history and first since C.J. Sapong in May 2017.
Western Conference leaders Sporting also enjoyed a fine win, thrashing the Colorado Rapids 4-0.
Alan Pulido, Andreu Fontas, Gadi Kinda and Gerso Fernandes netted in the victory.
Leandro Gonzalez Pirez's 89th-minute winner saw Inter Miami – without the suspended Gonzalo Higuain – edge Orlando City 2-1, while DC United overcame Atlanta United 2-1.
New York City recorded a 3-1 victory over the Montreal Impact and the Vancouver Whitecaps were too good for the San Jose Earthquakes 2-1.
The Chicago Fire and New York Red Bulls drew 2-2, Minnesota United edged Cincinnati 1-0, Houston Dynamo and Columbus Crew drew 1-1 and Real Salt Lake and Dallas played out a goalless draw.
Martinez equalised via an 86th-minute spot-kick to earn Atlanta a 1-1 draw with the Sounders at Lumen Field in Seattle on Sunday.
The Sounders had taken a sixth-minute lead from Raul Ruidiaz, who headed home Joao Paulo's corner to make it six goals in seven games.
Last season's MLS Cup runners-up Seattle remain undefeated and top of the Western Conference through seven matches, but had their four-game winning run ended as Atlanta – led by former Manchester United and Real Madrid defender Heinze – sit fifth in the east.
Last season's Supporters' Shield winners Philadelphia Union moved up into third in the east with a 1-0 victory away to DC United.
Kacper Przybylko netted the winner on the stroke of half-time for the Union, who are now unbeaten in their past four games.
Jamiro Monteiro laid off a perfectly weighted pass into the box for the Polish attacker to control and convert.
Union goalkeeper Andre Blake made a spectacular second-half save to deny United's 18-year-old midfielder Kevin Paredes with a curled effort from the edge of the box.
Undefeated Nashville edged past newcomers Austin 1-0 courtesy of a 35th-minute volley from Randall Leal.
Jared Stroud thought he had scored a second-half equaliser but it was disallowed by VAR for offside.
Nashville, who drew four of their opening five games, have won two of their past three matches to move up to fourth in the Eastern Conference, while Austin have lost three in a row on the road.
Super sub Ruidiaz came off the bench and scored a delightful game-winning goal just past the hour-mark as the Sounders downed Dallas 1-0 in MLS on Wednesday.
The Sounders were winless in 10 consecutive visits to Dallas (D3 L7, including play-offs) dating back to 2014 – their second-longest winless away run against a single opponent in MLS (11 straight at LA Galaxy from 2010 to 2015).
But Seattle snapped that skid thanks to Ruidiaz as Sporting KC's 1-1 draw with Portland Timbers allowed the Sounders to move top of the west by one point.
Atlanta extended their winning streak to three matches after Ezequiel Barco's first-half goal secured a 1-0 win at home to Toronto.
Since the sacking of head coach Gabriel Heinze following a falling out with star Josef Martinez, Atlanta – who had won successive matches for the first time since the opening two games of the 2020 season entering the fixture – have steadily climbed the table.
Atlanta are three points outside of the play-off positions in the Eastern Conference, which is topped by New England Revolution – 3-2 victors against DC United despite ending the contest with 10 men.
Elsewhere, Rodolfo Pizarro's stoppage-time winner guided Inter Miami to a dramatic 3-2 win against Chicago Fire midweek.
Pizarro struck in the 93rd minute to clinch a third straight home triumph for David Beckham's Inter Miami, who have now lost just once in their last six games.
Philadelphia Union and New York Red Bulls were 1-0 winners over New York City and Columbus Crew respectively, Vancouver Whitecaps topped Austin 2-1, Real Salt Lake defeated Houston Dynamo by the same scoreline, 10-man Montreal drew 0-0 with Cincinnati, while Nashville and Orlando City played out a 1-1 draw.
The Cascadia derby did not disappoint on Sunday, with the Sounders snapping a three-game winless streak behind Montero and Ruidiaz.
Entering the fixture, the slumping Sounders had won three of their last four away matches against the Timbers (L1) after winning just three of the first 14 MLS encounters in Portland (D3 L8, including play-offs).
Montero scored twice inside the opening 29 minutes to put the Sounders in control before Sebastian Blanco and George Fochive restored parity for the Timbers by the 52nd-minute mark at Providence Park.
Beginning with the 2018 playoffs, Ruidiaz had scored (eight) or assisted (two) on 10 of the Sounders' last 14 goals against the Timbers, including seven of eight goals in Portland (five goals and two assists) during that time.
Ruidiaz turned Sunday's match on its head with a stunning brace, including his memorable 55th-minute free-kick.
Jimmy Medranda's thunderous 77th-minute volley and Nicolas Benezet's stoppage-time effort completed the rout.
Seattle are second in the Western Conference, only a point behind Sporting Kansas City after 19 games, while Portland are eighth.
Elsewhere, Josef Martinez celebrated a long-awaited home goal as Atlanta United edged Los Angeles FC 1-0.
Martinez had not scored at Mercedes-Benz Stadium since October 2019, but the Venezuelan star ended his drought in the 47th minute.
Nashville are third in the Eastern Conference following their 5-2 drubbing of DC United – a victory inspired by CJ Sapong's brace, while snapping DC United's five-game unbeaten streak.
Chicago Fire topped defending champions Columbus Crew 1-0 via Luka Stojanovic's winner with 15 minutes remaining.
The Sounders remain undefeated through six matches this season thanks to a two-goal second half at Lumen Field in Seattle.
Entering the contest, Seattle had 13 points from their first five matches for the second time in the last three seasons – the only team in the last 20 seasons to have at least 13 points after five games more than once.
The Sounders stayed hot courtesy of Xavier Arreaga and Brad Smith – the former opening the scoring in the 57th minute.
Smith doubled the lead with 17 minutes remaining when the Australian full-back pounced for his third goal of the season.
The Sounders are four points clear of LA Galaxy in the Western Conference, while Sporting Kansas City are a point further back in third following their 3-0 win over Vancouver Whitecaps.
LAFC are bottom of the west with five points from five matches in 2021.
Former Juventus and Real Madrid forward Higuain was the hero for Inter Miami, who prevailed 3-2 in a thriller at Cincinnati.
Higuain scored the winning goal five minutes from the end after Cincinnati's Nick Hagglund has restored parity three minutes earlier.
David Beckham's Inter Miami – led by former Manchester United team-mate and head coach Phil Neville – raced out to a 2-0 half-time lead via Brek Shea and Higuain before Cincinnati rallied with goals from Alvaro Barreal and Hagglund.
Former Argentina international Higuain, though, had the final say with his fourth goal of the season.
Elsewhere, New England Revolution topped defending champions Columbus Crew 1-0 and Orlando City beat DC United by the same scoreline.
Orlando have opened the season unbeaten in their first five games (W2 D3). The Lions have lost just three regular-season matches since the end of the MLS is Back Tournament, fewer than any other team that was in MLS both last season and this.
Sporting claimed a 2-1 win over Minnesota United at Allianz Field to pull clear atop the Western Conference.
Michael Boxall's 55th-minute own goal proved decisive as Sporting claimed a fifth win in six MLS games, going four points clear of second-placed Minnesota.
Gadi Kinda got on the end of a Jaylin Lindsey cross to give Peter Vermes' Sporting a 12th-minute lead.
Minnesota were level just after the half-hour mark, an unfortunate deflection off Lindsey leading to an own goal.
But Boxall turned a cross into his own net 10 minutes into the second half for what proved to be the winner.
Toronto recorded a second win in four days over the Vancouver Whitecaps with a 1-0 victory.
Richie Laryea's low finish in the 15th minute was all Toronto needed, getting back to within a point of Eastern Conference leaders Columbus Crew.
In the day's other games, Cincinnati and DC United drew 0-0, while the Houston Dynamo's clash with Dallas also finished goalless.
Johnny Russell's 79th-minute goal gave Sporting KC a 2-1 win away to Seattle Sounders, locking up a play-off spot for the second-placed team in the Western Conference table as Russell netted for the seventh straight game.
Colorado also are in after defeating Portland Timbers 2-0 behind golas from Dominique Badji and Diego Rubio.
The Seattle loss ensured New England, who face Orlando City on Sunday, will finish atop the overall table. The Revs are on 69 points, 20 points clear of Philadelphia and Nashville in the Eastern Conference and 11 clear of Seattle overall.
Nashville had a chance to clinch the play-offs with a win but fell 1-0 to Philadelphia Union on Kacper Przybylko's first-half penalty.
Inter Miami got a goal and three assists from Gonzalo Higuain, while his brother Federico also found the net in a 5-1 rout of Cincinnati, who lost their ninth in a row.
Toronto dealt a blow to rival Montreal's play-off hopes as Jozy Altidore's free kick in the fifth minute of stoppage time secured a 1-1 draw after Sunusi Ibrahim had netted in the 55th minute for the visitors.
Minnesota and LAFC also finished at 1-1, as did San Jose Earthquakes and Vancouver Whitecaps.
New York City crushed DC United 6-0 and Sean Nealis' 87th-minute goal lifted New York Red Bulls past Columbus Crew 2-1.
Sebastian Lletget's brilliant 83rd-minute equaliser gave LA Galaxy a 2-2 draw with Dallas, while Chicago Fire downed Real Salt Lake 1-0.
The victory brought the visitors within two points of the first-placed Sounders in the MLS Western Conference table, with one fewer match played.
KC captain Johnny Russell set the tone in the 31st minute with a beautiful free kick from just outside the area to give the visitors the lead, and Daniel Salloi doubled the advantage before half-time.
After Fredy Montero answered for Sounders in the 51st minute, Cameron Duke sneaked behind the defence in the 72nd minute to seal the win.
KC are unbeaten in their last five matches and have only one loss in their last 10.
A brace from Gustavo Bou helped New England Revolution expand their lead atop the Eastern Conference with a 2-1 win over Montreal.
Kacper Przybylko found the net for the third straight game, putting home a rebound in the 85th minute to salvage a 1-1 draw for Philadelphia against Inter Miami as Phil Neville's side remain bottom of the table.
New York City FC matched their season-high in goals, scoring four times after the break in a 5-0 demolition of Orlando City.
Ola Kamara's 27th-minute goal gave DC United a 1-0 victory over New York Red Bulls.
Johnny Russell scored a goal and assisted two others as Sporting KC routed Minnesota at Children's Mercy Park on Wednesday.
Russell converted a penalty as part of a three-goal first half, with Khiry Shelton and Daniel Salloi also on target against the visitors.
Cameron Duke added a fourth goal seven minutes into the second half as Sporting KC found the back of the net in their 28th consecutive regular-season home game dating back to August 2019 – the longest active streak in MLS.
Sporting KC are a point clear in the west, though second-placed Seattle Sounders have played two games less, while Minnesota are two points outside the play-off positions.
San Jose Earthquakes star Javier Lopez scored a hat-trick, but Real Salt Lake still prevailed 4-3 in a wild clash.
Lopez opened the scoring in the 26th minute and completed his treble in the second half, however, RSL emerged victorious thanks to Rubio Rubin's brace.
The result snapped a five-match away losing streak for RSL, who ended San Jose's run of three consecutive wins over their rivals in MLS – a run that had equalled the longest streak by either team in history.
Elsewhere, former Manchester United and Real Madrid striker Javier 'Chicharito' Hernandez salvaged a 1-1 draw for LA Galaxy against Houston Dynamo.
Another ex-United star, Nani, was sent off in the first half as Orlando City were beaten 4-2 by Montreal, Ola Kamara's opening-half hat-trick lifted DC United past Chicago Fire 3-0, Atlanta United were 4-0 winners against FC Cincinnati courtesy of a Josef Martinez double, Los Angeles FC edged Austin 2-1 and 10-man Portland Timbers drew 2-2 with Colorado Rapids.
DC United appeared on track for victory following Nigel Robertha's ninth-minute opener away to New York City on Sunday.
That was until New York City – who have never lost a home match to DC United (W5 D2) – rallied, with Keaton Parks equalising in the 84th minute after flicking home a header from Maxi Moralez's corner.
Thiago then took centre stage in the 95th minute – the Brazilian embarking on a spectacular solo run from his own half, breezing by his opponents and finishing decisively.
New York City have scored in 21 consecutive MLS games (including playoffs). It is the longest active run in the league and longest in club history.
With the win, New York City are fourth in the Eastern Conference – six points adrift of leaders New England Revolution, who lost 2-1 to Dallas.
The Revolution were unable to restore their five-point lead atop the table following Ricardo Pepi's brace for Dallas.
Homegrown star Pepi was the hero for Dallas, who snapped their six-game winless streak by topping the Eastern Conference leaders.
In other results, Atlanta United and New York Red Bulls played out a goalless draw, while Austin and reigning MLS champions Columbus Crew also drew 0-0.
Sibling pair Diego and Yimmi Chara were among the goals as the Timbers – unbeaten in six matches – eased past RSL at Providence Park on Saturday.
Felipe Mora, Dairon Asprilla, Jaroslaw Niezgoda and Cristhian Paredes also scored for the Timbers, who have netted in 16 consecutive matches against RSL (including play-offs) – the second longest streak against any opponent in their history, behind the 17 straight versus Dallas from August 2012 to March 2018.
The Timbers led 2-1 at half-time before putting RSL to the sword in the second period to match their six-game unbeaten streak from September-October last season.
Portland are fourth in the Western Conference, six points behind leaders Sporting Kansas City, while RSL occupy the seventh and final play-off position in the west.
Los Angeles FC are three points outside the top seven following their 2-0 defeat to San Jose Earthquakes, while Vancouver Whitecaps are also on 33 points after topping Dallas 1-0.
The Union defeated Atlanta 1-0 thanks to Kacper Przybylko's goal with less than 20 minutes remaining.
Back-to-back wins sent Philadelphia up to fourth in the Eastern Conference as Atlanta's three-game winning streak came to an end to leave them eighth in the east and outside the post-season positions.
In other results, Supporters' Shield leaders New England Revolution were 2-1 winners over Orlando City.
The Revolution extended their MLS single-season record for wins by one-goal margins to 16. Nine of New England's last 10 MLS victories have come by a one-goal margin.
It continued Orlando's misery against New England – the team have never won at the Revolution (D1 L5), the only side they have visited more than three times without recording a victory in MLS play.
DC United prevailed 4-2 against FC Cincinnati, New York Red Bulls overcame rivals New York City 1-0, defending champions Columbus Crew won 2-1 against Montreal, Houston Dynamo lost 2-0 to Minnesota United, while Colorado Rapids and Toronto played out a 0-0 draw.
Patrick Mullins' first-half goal saw Toronto edge FC Cincinnati 1-0 on Sunday to book a spot in the play-offs.
Mullins produced a side-footed finish from inside the area after a Richie Laryea cutback just before the half-hour mark.
Toronto are top of the Eastern Conference and three points clear of Philadelphia Union.
Philadelphia won six straight home regular-season matches for the first time in their history, as per Opta, thanks to a 2-1 win over Montreal Impact.
Danny Musovski scored a double as LAFC enjoyed a 3-1 victory against Seattle Sounders.
LAFC are fourth in the Western Conference, which the Sounders top.
Erik Hurtado scored a spectacular volley to see Sporting Kansas City edge a 10-man Nashville 2-1.
Hurtado produced a wonderful finish from Amadou Dia's lofted pass to earn Sporting three points.
New England Revolution beat New York City 2-1, Chicago Fire were 2-1 winners over DC United and Jaroslaw Niezgoda netted twice as Portland Timbers claimed a 3-0 victory against San Jose Earthquakes.
Toronto moved level on points with Philadelphia after a 2-1 win over Inter Miami and the Union's 2-1 defeat to Columbus Crew on Sunday.
Columbus took a 37th-minute lead at home, Artur finding the bottom corner from 20 yards.
However, Philadelphia drew level in the 57th minute thanks to a penalty from Jamiro, although the hosts would strike late.
Krisztian Nemeth got on the end of a Luis Diaz Espinoza cross from the right to tap away a winner six minutes from time for Columbus, who are third in the Eastern Conference.
Toronto boosted their chances of winning the Supporters' Shield by overcoming Inter Miami.
Former Juventus midfielder Blaise Matuidi opened the scoring for Inter Miami with his first MLS goal.
But Toronto would win after conceding the opening goal for the third time this season, which is tied for the most with San Jose Earthquakes, as per Opta.
Ayo Akinola scored a fine equaliser after outmuscling his opponent before Gonzalo Higuain almost responded for Inter Miami, hitting the crossbar with a powerful 20-yard effort in the 79th minute.
Instead, Alejandro Pozuelo tucked away an 84th-minute penalty for the winner for Toronto.
Pozuelo has scored each of his past seven penalties for Toronto in MLS.
Valentin Castellanos scored a hat-trick to inspire New York City to a 5-2 derby win over the Red Bulls.
Castellanos became just the second player to net a hat-trick in the Hudson River Derby, joining David Villa (2017).
Elsewhere, Teal Bunbury's brace saw New England Revolution overcome DC United 4-3 in a thriller and Atlanta United beat Cincinnati 2-0.
Orlando City edged Montreal Impact 1-0, Colorado Rapids beat Seattle Sounders 3-1, the Portland Timbers overcame the Vancouver Whitecaps 1-0 and LA Galaxy edged Real Salt Lake 2-1.
Alejandro Pozuelo's fine run of form continued as Toronto came from behind to beat the Philadelphia Union 2-1 in Connecticut.
Sergio Santos' delicate chip had put Philadelphia ahead in the fifth minute, but Toronto fought back in the second half.
Ayo Akinola headed in a Tony Gallacher cross from the left approaching the hour-mark to bring Greg Vanney's side level.
Pozuelo scored what proved to be the winner in the 76th minute, heading in at the back post following a corner.
As Toronto won for the 10th time in their past 13 meetings with the Union, Pozuelo has been directly involved in 10 goals since the MLS regular season resumed in August, as per Opta.
Toronto joined Columbus on 31 points atop the Eastern Conference after the Crew were held to a 2-2 draw by Dallas.
LA Galaxy are bottom of the Western Conference after slumping to a 2-1 loss to the San Jose Earthquakes in the California Clasico.
The Galaxy seemed on track when Sebastian Lletget put away the opener after Javier Hernandez hit the post, and goalkeeper David Bingham saved Chris Wondolowski's 12th-minute penalty.
But Marcos Lopez drilled in a wonderful equaliser before half-time, and Andres Rios made no mistake with San Jose's second spot-kick of the game in the 82nd minute.
Orlando City continued their fine season with a 3-1 victory over the New York Red Bulls.
The club's tally of 29 points from their first 15 matches is five more than they have ever had through the same number of games in any previous campaign, according to Opta.
Gonzalo Higuain's Inter Miami fell to a 3-2 loss to New York City, while Atlanta United crushed DC United 4-0.
Montreal Impact and Chicago Fire drew 2-2, Alan Pulido scored a brace as Sporting Kansas City edged Houston Dynamo 2-1 and Minnesota United enjoyed a 2-0 victory over Cincinnati.
Western Conference leaders the Seattle Sounders beat the Vancouver Whitecaps 3-1, while the clash between the New England Revolution and Nashville finished goalless.
