Two of the shining lights of the campaign face off in Buffalo as the Bills host the Minnesota Vikings.
History will be made in Munich as the Tampa Bay Buccaneers face the Seattle Seahawks in the first-ever regular season NFL game played in Germany, while the San Francisco 49ers will look to continue their return to winning ways against the Los Angeles Chargers.
Stats Perform takes a closer look at the numbers behind some of Sunday's NFL clashes.
Minnesota Vikings (7-1) @ Buffalo Bills (6-2)
The Vikings have played eight games at Highmark Stadium and have held the Bills to 23 points or fewer in each one, which is the longest streak of allowing 23 points or fewer by a visiting team in the stadium's history.
Minnesota have won six straight games, all by eight points or fewer, tied for the second-longest streak of one-possession wins in NFL history, behind a seven-game streak by the Kansas City Chiefs in 2020.
T.J. Hockenson boasted nine catches on his Vikings debut last week, tying the Bills' Keith McKeller (October 18, 1987) for the most receptions by a tight end on debut with a team in the Super Bowl era.
The Bills have allowed 21 points or fewer in 12 straight regular-season games, the longest streak in franchise history and the second longest by any NFL team over the last 15 seasons (Baltimore Ravens, 13 straight from 2019-20).
Buffalo are allowing just 4.6 points per game in the second half this year. No NFL team has allowed fewer than 5.0 points per game in the second half over a full season since the Carolina Panthers in 1996 (3.5).
Seattle Seahawks (6-3) @ Tampa Bay Buccaneers (4-5)
It should be a great experience in Bavaria, but the Bucs are 0-3 in games played outside the United States (all in London), having been outscored 96-51 in those games. The Seahawks, meanwhile, are 2-0 outside the U.S. (one in Toronto, one in London), outscoring their opponents, 77-20.
Pete Carroll is in his 17th season as an NFL head coach and has had at least six wins in each campaign. The only other coach to have six or more wins in each of his first 17 seasons was Don Shula, who did so in all 33 seasons of his career.
Kenneth Walker III is the first NFL rookie to rush for a touchdown and have his team win in each of his first four career starts since Robert Edwards for the New England Patriots in 1998.
Tom Brady has thrown at least 40 passes with no interceptions in seven consecutive starts. No other QB in NFL history has done that in more than four straight starts.
The Bucs have rushed for 75 or fewer yards in eight straight games, the second-longest streak in the Super Bowl wera behind a nine-game streak by the Cardinals from 1991-92.
Los Angeles Chargers (5-3) @ San Francisco 49ers (4-4)
The Chargers are looking to win their sixth-straight game against the 49ers, which would make them the first team to do so since the Seahawks (nine games from 2014 to 2018).
Justin Herbert was not sacked in the Chargers' recent win against the Atlanta Falcons. The Chargers have allowed the fewest sacks in the league this season (10), and have not allowed 10 or fewer sacks through eight games since the 2008 season (also 10).
Through 40 career starts, Herbert has played a part in 90 touchdowns (82 passing, eight rushing). Only Patrick Mahomes (107), Dan Marino (95) and Kurt Warner (91) accounted for more scores in their first 40 starts.
San Francisco's last five games have all been decided by at least 14 points (3-2 record). They have not had six consecutive such games since an eight-game streak in 1999.
Christian McCaffrey threw for, rushed for and caught a touchdown in San Francisco's win over the Rams. He was the first player to do so since the Chargers' LaDainian Tomlinson completed the feat in Week 6 of the 2005 season.
Elsewhere...
The Jacksonville Jaguars (3-6) will need a plan to deal with Chiefs (6-2) QB Mahomes, who attempted 68 passes (completing 43) in last week's win over the Tennessee Titans, both of which set single-game team records. The only player to attempt more passes in a win in the NFL since 1950 was Drew Bledsoe with 70 in Week 11 of the 1994 season.
Former Chief Tyreek Hill has 1104 receiving yards this season for the Miami Dolphins (6-3), the most by any player through his team's first nine games in the Super Bowl era. Prior to this year, there had only been 11 times a Dolphins receiver recorded 1100 yards in an entire season, and Hill will look to add to those against the Cleveland Browns (3-5).
Last week was Cooper Kupp's 20th career game with at least 100 receiving yards and a touchdown, the most in the NFL since he entered the league in 2017. The only other players with more than 15 such games in that span are Davante Adams (19) and Hill (18), and the Los Angeles Rams (3-5) will need their star to step up again against the Arizona Cardinals (3-6).
Aaron Rodgers' passer rating is at 89.0 this season after posting 111.9 in 2021. The decrease of 22.9 is the largest by a Green Bay Packers quarterback (min. five games played) since Bart Starr from 1966 to 1967 (105.0 to 64.4). With a record of 3-6, the Packers will hope he can improve that against the Dallas Cowboys (6-2).