The Leewards were bundled out for 68 in 19.4 overs after winning the toss.
Captain Jahzara Claxton was the only batter in double figures for the Leewards with 25 as Trisha Hardat ripped through the batting on her way to a match-winning 4-10 off her four overs.
She was well supported by Danellie Manns who took 2-14 from four overs.
Guyana were then on their way to a comfortable chase at 63-5 in the 12th over before rain came and brought proceedings to a close.
At the time of the delay, Guyana were 63-5, 23 runs ahead of the DLS par score.
Naomi Barkoye led the way with 24 while Shonette Belgrave made 21.
Amara Richards and Sainvani Kambalapalli took two wickets, each, to help the Leewards effort.
At Diego Martin Sports Complex, 2023 champions Trinidad & Tobago defeated the Windward Islands by five wickets to claim third place.
T&T restricted the Windwards to 67-7 off their 20 overs after winning the toss and fielding first.
Nesha Alexander with 18, captain Zaida James with 11 and Denella Creese with 10 were the only Windwards batters into double figures as Kenika Cassar bowled brilliantly on her way to figures of 2-5 from her four overs.
Kirah Manpaul took 2-8 from her one over in support.
Trinidad & Tobago then needed 17 overs to reach 68-5. Brianna Harricharan led the way with 17* while Katrina Ruben made 12.
Amiah Gilbert took 2-18 from two overs.
At the Sir Frank Worrell Memorial Ground, Jamaica defeated Barbados by seven wickets to claim fifth place.
Barbados, after winning the toss and batting first, were bowled out for 63 19.1 overs by the Jamaicans.
Naijanni Cumberbatch led the way for the Bajans with 20. Moniqueca Reid took 3-20 from her four overs for Jamaica while Sashane Ricketts took 2-1 from 1.1 overs.
Chrishana McKenzie then spearheaded a successful chase with 21* while Jaunel Deers made 17 as Jamaica reached 64-3 in 19.3 overs.
At the same venue on Thursday, the Leewards secured a seven-run win over Jamaica via the DLS method.
The Leewards first posted 124-6 from their 20 overs after being put in to bat by the Jamaicans. Captain Jahzara Claxton led the way with 29 while Sainvani Kambalapalli made 22 and Kimberley Anthony made 20.
Brianna Plummer, Abigail Bryce and Aneisha Miller each took two wickets for Jamaica.
At the time of the rain delay, Jamaica were 55-3 off 10.4 overs, seven runs short of the DLS par score.
At the Sir Frank Worrell Memorial Ground, Guyana, who booked their spot in the final thanks to wins in the first four rounds, suffered a narrow two-wicket loss to the Windward Islands in round five.
The Guyanese were bundled out for just 60 in 18 overs after winning the toss. Nesha Alexander was the pick of the Windwards bowlers with 4-8 from her four overs while Selena Ross took 3-8 off three overs in support.
The Windwards then hade a tough time of it in their chase, needing 18.3 overs to reach 61-8.
Denella Creese led the way with 25 as Trisha Hardat and Nyia Latchman tried their best with the ball for Guyana.
Hardat took 2-2 from two overs while Latchman took 2-6 from her four overs.
The other round five fixture saw Barbados defeat Trinidad & Tobago by 12 runs via the DLS method at the Diego Martin Sports Complex.
Barbados made 100-5 from their 20 overs after being put in to bat. Asabi Callender led the way with 40 while Naijanni Cumberbatch made 30* against 2-9 off four overs from Kenika Cassar and 2-13 off three overs from Brianna Harricharan.
Trinidad & Tobago’s target was then revised to 95 off 18 overs due to rain.
They lost wickets early and never recovered, eventually being restricted to 82-9 off 18 overs.
Erin Deane starred with 4-12 from her four overs while Cumberbatch and Nia Wood took 2-14, each.
Also on Saturday, Trinidad and Tobago will face the Windward Islands in the third-place playoff at the Sir Frank Worrell Memorial Ground while Jamaica will face Barbados in the fifth-place playoff at the Diego Martin Sports Complex.
At the Diego Martin Sporting Complex, leaders Guyana secured a dominant 81-run win over Jamaica.
Guyana made 133-7 from their 20 overs after winning the toss. Naomi Barkoye led the way with 46 off 34 balls while captain Realeanna Grimmond made 31 off 30 balls in support.
Abigail Bryce took 3-22 from four overs for Jamaica.
Danielle Manns then starred with 4-15 from her four overs to help bundle out the Jamaicans for a paltry 52 in just 15.2 overs.
Nyia Latchman took 2-8 from 3.2 overs while Trisha Hardat took 2-11 from two overs.
At the Sir Frank Worrell Memorial Ground in St. Augustine, hosts Trinidad & Tobago defeated the Leeward Islands by four wickets.
The Leewards, after winning the toss, were restricted to just 82-8 from their 20 overs.
Captain Jahzara Claxton made a patient 42* off 64 balls to lead the Leewards effort against 2-15 off four overs from Kenika Cassar.
T&T then made a meal of the chase, needing 19.4 overs to reach 83-6. Captain Samara Ramnath led the way with 35 against 2-19 from four overs from Kimberley Anthony.
The match between Barbados and the Windward Islands at the Brian Lara Cricket Academy ended in a no result.
