France talisman Antoine Dupont has recovered from coronavirus in time to captain Les Bleus in their Six Nations opener against Italy on Sunday.

World Rugby Player of the Year Dupont had withdrawn from his country's initial squad for the Championship having tested positive, yet he has now been cleared to return for matchday one.

The scrum-half, who is skipper in place of the injured Charles Ollivon, was the 2020 Player of the Championship and starred again in 2021 as France came agonisingly close to the title, leading the tournament with five try assists.

Four of those assists came in last year's meeting with Italy, becoming the first player to achieve that feat in a single game in Six Nations history.

Les Bleus are not quite clear of COVID-19 for this clash, however, as coach Fabien Galthie will be absent following his positive test, meaning general manager Raphael Ibanez is in charge.

He comes up against Kieran Crowley in his first Six Nations match as Italy coach in Saint-Denis.

Crowley has named a youthful Azzurri side, including two debutants in the XV in Tommaso Menoncello and Toa Halafihi.

Italy have only won one of 24 away Tests against France – back in March 1997 – and come into this match on a record 32-game losing run in the Six Nations.

France team: Melvyn Jaminet, Damian Penaud, Gael Fickou, Jonathan Danty, Gabin Villiere, Romain Ntamack, Antoine Dupont (captain); Cyril Baille, Julien Marchand, Uini Atonio, Cameron Woki, Paul Willemse, Anthony Jelonch, Dylan Cretin, Gregory Alldritt.

Replacements: Peato Mauvaka, Jean-Baptiste Gros, Demba Bamba, Romain Taofifenua, Francois Cros, Maxime Lucu, Yoram Moefana, Thomas Ramos.

Italy team: Edoardo Padovani, Tommaso Menoncello, Juan Ignacio Brex, Marco Zanon, Montanna Ioane, Paolo Garbisi, Stephen Varney; Danilo Fischetti, Gianmarco Lucchesi, Tiziano Pasquali, Niccolo Cannone, Federico Ruzza, Sebastian Negri, Michele Lamaro (captain), Toa Halafihi.

Replacements: Epalahame Faiva, Ivan Nemer, Giosue Zilocchi, Marco Fuser, Giovanni Pettinelli, Manuel Zuliani, Callum Braley, Leonardo Marin.

The 2022 Six Nations campaign begins with a mouth-watering contest between defending champions Wales and a well fancied Ireland side at the Aviva Stadium in Dublin on Saturday. 

Wales won the championship for a sixth time last March, narrowly missing out on a Grand Slam with defeat to France in their final game, but they enter this year's tournament as outsiders in the eyes of many.

Much like Ireland, France will be eyeing top spot after going 12 years since their most recent triumph – Les Bleus' longest-such run since joining the Five Nations in 1947 – with their campaign beginning at home to an Italy side without a win in 32 games in the competition.

A relatively inexperienced England side do battle with perennial dark horses Scotland at Murrayfield for the Calcutta Cup, meanwhile, with the hosts looking to record back-to-back wins in this fixture for the first time since 1984.

Ahead of the opening round, Stats Perform previews the upcoming matches with help from Opta.

IRELAND v WALES

FORM

Ireland have won four of their last five meetings with Wales, though their solitary defeat in that run came in the most recent match between the sides in last year's Six Nations when going down 21-16.

Wales have lost their last four away games against Ireland, their worst-such run since losing four in a row between 2002 and 2006, but never before have they lost five in a row away to Ireland.

Ireland have won 27 of their last 29 Tests at the Aviva Stadium, including their last six in a row, with their only defeats coming against England in 2019 and France in 2021 – both in the Six Nations.

ONES TO WATCH

Johnny Sexton will win his 102nd international cap for Ireland this weekend and remains a key player for his country. The 36-year-old recorded the best goal kicking success rate of any player (minimum of three kicks) in last year's Six Nations, finding the target from 25 out of 26 (96 per cent).

Wales are without a long list of players due to injury, most notably skipper Alun Wyn Jones. It's set to be the first Six Nations the Dragons have played without Jones since 2006, with fly-half Dan Biggar being left with big shoes to fill in his first game as captain.

SCOTLAND v ENGLAND

FORM

Scotland have won five of their last six Test matches, with their solitary defeat in that run coming against the world champions South Africa in November.

England have won 15 of their last 18 Tests, including their last five in a row, although their three defeats in that spell all came in last year's Six Nations – just the fourth time they had lost more than twice in an edition of the tournament since 2000 (also lost three in 2005, 2006 and 2018).

This will be the 140th Test between the rival nations in a fixture that dates back to the first ever rugby international back in 1871. Scotland have won on 44 occasions, compared to 76 victories for England, with the other 19 ending all square.

ONES TO WATCH

Scotland have named a near-identical XV to the one that ended last year's Six Nations, Duhan van der Merwe among them. The British and Irish Lions wing beat 31 defenders in the 2021 edition, surpassing Brian O'Driscoll's record for the most in a single Six Nations (30 in 2000).

In the absence of Owen Farrell and Courtney Lawes, Tom Curry will captain England at the age of just 23, making him the youngest player to do so since Will Carling in 1988.

FRANCE v ITALY

FORM

France and Italy have met on 45 occasions, with Les Bleus winning 42 of those matches. That 93 per cent win rate is their highest against any nation they have faced more than five times.

Italy have lost 23 of their last 24 away games with France in Test rugby, including their last 14 in a row. The Azzurri's only victory in France came in Grenoble in 1997.

France have won 12 of their last 13 Test matches at home, although their solitary defeat in that run came in their most recent Six Nations game against Scotland. They have not trailed at half-time in a home game since February 2018, going into the break ahead (17 times) or level (twice) in each of their last 19 such games.

ONES TO WATCH

Captain and recently crowned World Rugby Player of the Year Antoine Dupont will be looking to pick up from where he left off in 2021. He was directly involved in eight tries during the last Six Nations, more than any other player, scoring three and assisting a Championship-high five.

Sebastian Negri made 64 carries and 68 tackles during the 2021 tournament, his combined tally of 132 carries and tackles being the second most of any player in the Championship, behind only Taulupe Faletau (140). Italy could do with more of the same here to help avoid another loss.

France head coach Fabien Galthie will miss the Six Nations favourites' opening game against Italy after a positive COVID-19 test.

The 52-year-old said he was experiencing only mild symptoms of the coronavirus, and the French Rugby Federation (FFR) stated Galthie would stay involved with the team from afar.

The FFR said: "Fabien Galthie tested positive for COVID-19 on Thursday, February 3, via an antigen test according to the established protocol. The result has been confirmed by a PCR test this Friday, February 4."

Galthie will be able to rejoin the squad from February 8, if he tests negative by then, or February 10.

France team manager Raphael Ibanez is set to stand in for Galthie when Italy visit the Stade de France on Sunday.

There were no more COVID-19 cases detected when the France squad were tested on Friday morning, the FFR said, with another round of testing planned for Saturday.

Galthie said: "This morning, I have tested positive for COVID-19. I'm feeling fine with mild symptoms. As a consequence, I'm isolating and will work remotely this week. Raphael Ibanez and all of my staff, in whom I have full confidence, will be my go-betweens on the pitch."

France cancelled their scheduled Friday news conference as a result of Galthie's test result.

Les Bleus, who finished second in last year's championship but have not won the Six Nations since 2010, are rated as favourites with the bookmakers for the title this time around.

Eleven months on from playing the roles of party poopers against the same opponents, France will this weekend set out on a journey that Fabien Galthie and his men will hope ends with the Six Nations trophy being held aloft at the Stade de France on March 19.

Les Blues denied Wales Grand Slam glory with an enthralling 32-30 victory in Paris in the Dragons' final match of an otherwise perfect 2021 campaign, snatching the win through an injury-time Brice Dulin try, but they ultimately fell short by finishing four points adrift in second.

Now on their longest run without winning the championship since joining the Five Nations in 1947, with their most recent triumph coming in 2010, France will consider anything other than first place this time around a real disappointment.

But if that is to happen, then Galthie's side have a number of obstacles to navigate, not least beating defending champions Wales – now one shy of England's record of seven Six Nations crowns – in Cardiff in the fourth round of fixtures.

Wales have been Six Nations champions four times in the last 10 years, yet few are giving them much of a chance this time around after failing to push on in the second half of 2021.

Wayne Pivac's side are without inspirational skipper Alun Wyn Jones and do not exactly have history on their side, having won back-to-back championships just once – doing so in 2012 and 2013 – but the Dragons do at least play three of their five matches on home soil.

A fast start is imperative but a first-round trip to in-form Ireland presents the reigning champions with arguably their toughest assignment of the tournament. Champions in 2018, four barren years would feel like a lifetime should Ireland miss out again.

Andy Farrell's charges are certainly not lacking momentum thanks to a strong end to the last campaign. Eight wins in a row, including a famous triumph over New Zealand in November – only their third win in that fixture in 33 meetings – has them riding the crest of a wave.

A lack of playing time at club level for certain players could hamper Ireland in their opener, however, setting up an intriguing game to kick things off on Saturday at the Aviva Stadium.

While it is clear what can be expected from France, Ireland and Wales, fellow heavyweights England enter this latest edition as something of an unknown quantity due to injury absentees, skipper Owen Farrell among them.

Tom Curry will have to step up and lead an inexperienced England side that contains seven players with 10 caps or fewer in their starting XV to face Scotland. It will make for a challenging six weeks from Eddie Jones' perspective, but one he will be relishing in his seventh Six Nations with the Red Rose.

England are one of two sides, along with Ireland, yet to collect the Wooden Spoon. That cannot be said of Italy, who have propped up the table in each of the last six years, that after finishing bottom only once in the previous four campaigns.

Another disappointing 2021 saw Italy lose all five matches as their losing run in the tournament stretched to 32 games, the longest such streak in either Five or Six Nations history.

Italy's place in future competitions continues to be debated, with a possible promotion and relegation system being touted by some, but for now the Azzurri will simply be focused on proving their doubters wrong by ending a long-running losing streak that stretches back to 2015.

While there are some promising signs at age-group level, it is hard to see past Italy claiming an unwanted 17th Wooden Spoon this time around, particularly with trips to Paris, Dublin and Cardiff to prepare for.

Exactly who Italy will battle it out for to avoid bottom spot is a tougher question to answer than predicting an overall winner, with Scotland one of those whose campaign could go either way.

Experienced but too inconsistent, Gregor Townsend's perennial dark horses need to find a way to string together a run of victories to remain in contention right until the end. 

The hallmarks of a great team were there 12 months ago when enjoying more possession (58 per cent) and territory (55 per cent) than any other side, as well as managing the best tackle success rate (91 per cent), but there are still a number of issues that need to be ironed out.

That is a running theme throughout, though, and all adds to the unpredictability and excitement.

With fans back inside grounds, scores to be settled and no shortage of subplots, it is easy to see why this year's Six Nations is the most anticipated in several years.

Eddie Jones insists Tom Curry is the perfect choice to lead England into their Six Nations campaign as he compared his new captain to New Zealand great Richie McCaw.

With Owen Farrell and Courtney Lawes ruled out through injury, Curry was named as skipper on Thursday ahead of this weekend's opening clash against Scotland.

At the age of 23, Curry becomes England's youngest captain since 22-year-old Will Carling in 1988, yet the youngster already has 36 senior caps to his name.

Curry also has experience of representing the British and Irish Lions, and England boss Jones is comfortable with his choice to hand the Sale Sharks flanker the armband.

"Captaincy is not about the number of caps, it's about the person who can lead a group of players by example," Jones said at his pre-match news conference.

"There is no better player in our squad than Tom to do that. He reminds me of a young Richie McCaw."

McCaw earned 148 Test caps for New Zealand across a celebrated career that saw him win two World Cups and three World Player of the Year awards.

England begin their quest for a fourth Six Nations title in seven attempts under Jones with a trip to Scotland on Saturday.

The Red Rose have won only one of the past four Calcutta Cup clashes, having previously won eight in a row, which Jones believes makes his side second favourites this week.

"It's all about getting the team on the front foot. That goes in line with how we want to play the game," Jones said.

"We want to go up there and take Scotland on. It's the first time I'm going up there as underdogs and where Scotland are red-hot favourites. They're expected to win.

"Every time the players will look at the crowd, they will feel that expectation. They've got to cope with that. There will be 62,000 fans and they'll be thinking about all the fans watching on TV. They've got to carry that burden. Every game is the same for us.

"We're always expected to win, so it's no different for us. We've had a really good preparation and feel we have enough in our set-piece to get an advantage."

England have included seven players with 10 caps or fewer in their starting XV for the showdown at Murrayfield.

Scotland have gone with a more experienced side, with the headline news being Jonny Gray's return after missing the autumn series through injury.

Stuart Hogg will once again captain the side at full-back, with replacement Ben White the only uncapped player in the squad.

Scotland team: Hogg (c); Graham, Harris, Johnson, Van der Merwe; Russell, Price; Sutherland, Turner, Z Fagerson, Gray, Gilchrist, Ritchie, Watson, M Fagerson.

Replacements: McInally, Schoeman, Nel, Skinner, M Bradbury, White, Kinghorn, Tuipulotu.

England team: Steward; Malins, Daly, Slade, Marchant; Smith, Youngs; Genge, Cowan-Dickie, Sinckler, Itoje, Isiekwe, Ludlam, Curry (c), Simmonds.

Replacements: George, Marler, Stuart, Ewels, Dombrandt, Randall, Ford, Nowell.

Wales will give Josh Adams his first international start at centre when they take on Ireland in their opening game of their Six Nations title defence at the Aviva Stadium on Saturday.

The Cardiff Blues star, who has scored 17 tries in 35 Tests for Wales, will be given the number 13 jersey for the first time as head coach Wayne Pivac attempts to rediscover the magic achieved in last year's tournament when he moved George North to the role.

Adams will play in the midfield alongside Nick Tompkins, while Will Rowlands is back in the starting line up alongside vice-captain Adam Beard.

Taine Basham will be making his debut in the Six Nations in the back row with Aaron Wainwright and Ellis Jenkins.

George North is looking forward to the day his children face the big choice: cycling or rugby.

North is also looking forward to the Six Nations Championship, starting this weekend, when Wales begin their title defence against Ireland in Dublin.

There is an awful lot for this 29-year-old to be looking forward to, now that his injury hell has passed.

For now, North is enjoying the freedom of being able to run again, after suffering an anterior crucial ligament (ACL) injury in his right knee last April, playing for the Ospreys.

It ended his year on the rugby pitch, ruining hopes of a starring role for the British and Irish Lions in South Africa and denying him a shot at the Springboks, Australia and New Zealand in the autumn internationals.

North would sooner have been healthy and active of course, but being sidelined has had its upsides. He and his wife, double Olympic cyclist silver medallist Becky James, welcomed their second son, Tomi, a brother for Jac, in October.

Rather than dividing his time between the family and Wales camps, North has been essentially a stay-at-home dad for months on end.

"It's been brilliant. Normally I'm away playing or touring or something," says North, who is a Land Rover ambassador.

"To have this time at home, it's priceless. But Becky's been a superstar. When I had my surgery to start with, I couldn't do much on crutches with Jac, and obviously Tomi's joined us now and he's class.

"I'm in that stage now where effectively I'm in pre-season again, and I'm absolutely battered when I come home from training. And I'm not much use to anyone, but she's been amazing through this whole process.

"It has been tough, but it's been amazing you know, the two boys are amazing. Thank goodness for Becky, because it'd have been a lot harder at one point, with one leg up and hopping around the place. Especially my surgery, it was very tough. But yeah, she's a superhero."

Wales have been Six Nations champions four times in the last 10 years. Despite being holders, however, few are giving them much of a chance this time around.

After all, Wales have been up and down with results in the tournament. Across the last five years, they have trailed in fifth twice, as well as clinching a couple of championships, including the 2019 grand slam.

This time, they head into the tournament without a clutch of key players: North is absent, but so too is captain Alun Wyn Jones, with Taulupe Faletau, Leigh Halfpenny, Josh Navidi, Ken Owens and Justin Tipuric also sidelined.

Head coach Wayne Pivac said his squad has lost around 680 caps' worth of experience, but Wales should still be no mugs.

The players Pivac has chosen for the tournament come with an average of 27.1 Test caps of experience, only topped by Ireland's 30.9 among the six teams.

Those that are missing are proven class, however. In last year's championship, Faletau had 66 carries, putting him in third place among all players, while Tipuric made the most tackles (82). Faletau was fourth on that list (74), and skipper Jones was sixth (72).

On the Six Nations all-time list, North, who has featured on the wing and at outside centre, ranks fourth for metres gained (2,548), third for defenders beaten (126), and third for most clean breaks (48).

Jones is top of the all-time tackles chart (719), with fly-half Dan  Biggar a different animal to the absent lock. Biggar sits second on the Six Nations' all-time try assists list, after setting up 17 five-pointers in the competition.

To lose a raft of proven top-level talent would hurt any team, and North is not blind to that. He has been in and around the Wales squad since his late teens, however, so is certain there will be no defeatist attitude in Pivac's camp.

"Obviously there are a number of players out missing, and I think Wayne's come out with a stat of something like 680 caps that he's lost," says North. "That's a tough place to be."

But can Wales kick on regardless? North says so.

"Well, that that's the only way you get better, isn't it? By pushing the standards up every time," North tells Stats Perform News.

"I think for us, as Wales, we're used to being the underdogs, and we're always used to being kind of like always wanting more, and I think that shows in the performances that we have and the results we have had of late.

"From the lads' point of view, that's something they will certainly be looking at: how they push on from last year. Obviously winning the championship [is one thing], but you know the next step is backing it up again and as we said, it's going to be incredibly tough for the boys."

In the 2021 Six Nations, Wales made the most tackles of all teams (871), were third for tackle success with a healthy 88.2 per cent record, ranked second for lineout success with 90.8 per cent, and matched France for the most scrum success with 96.2 per cent.

Pivac's side averaged 3.7 points per entry into the opposition 22, making them the only side to average over three points per entry. It is a hard act to follow.

The loss of veteran skipper Jones gives 32-year-old playmaker Biggar the opportunity to lead the team into the championship.

"Yeah, it's not easy following the most capped player in the world is it!" North says. "I wouldn't like to follow Alun Wyn, put it that way.

"But what you're getting with Dan is a fierce competitor who drives the squad from the front row, right the way back all the way through to the full-back.

"He expects high standards of everyone, and he expects those standards of himself. I'm excited to see Dan as captain because what you see on the field is a fierce competitor. And that's not just on the field, that's Monday to Friday, and that's in whatever jersey he is.

"He expects the best for himself, and also the best from others because you know he is a competitor and wants to win."

North has the most international tries of all current players in the world game, and he has spoken of hoping to be available to Pivac at the back end of the championship.  Wales have home games against France and Italy on March 11 and 19 to finish the campaign.

He longs to make his children proud, even though both are much too young to understand his day job, or to understand their mother was a world champion.

From the routines of parenthood to the cauldron of the Principality Stadium, North is focused on pulling out all the stops. Jac and Tomi are keeping him grounded but also fuelling his ambitions.

"Obviously they don't know what Dad does. They don't know what Mum used to do," he says. "And I think that's something that's special.

"I am looking forward to the day that I'd be able to play and Becky can bring the boys to watch. I'm incredibly proud and honoured to be able to play rugby, but to be able to share that with the boys and, you know, show them more. Whatever they want to do in the future, there's always that conversation, is it a bike or a rugby ball?"

North, who during last year's Six Nations became the youngest player to reach 100 caps for any country, is targeting the 2023 Rugby World Cup as a long-range goal.

That could add up to over two months away from home, and given he will be 31 by the time that tournament comes around, it might be a last shot at global glory.

"I've got a fair few steps to cross off before we get back in any jersey. Certainly it's something I want to be able to put my hand up and be fighting for my selection there," he says.

"I've been very fortunate to go to a few now, and you know that's a big push. It's not too far away, and it's something that is certainly exciting."

There he goes again, always looking forward.

:: George North is a Land Rover ambassador. Visit landrover.co.uk

James Bhatti has withdrawn from Scotland's squad for their opening Six Nations match, while Gregor Townsend will also be without Josh Bayliss.

Scotland face England in their first game of the tournament at Murrayfield on Saturday.

However, Bhatti, a loosehead at Glasgow Warriors, has withdrawn from the squad due to injury.

Bayliss, meanwhile, will remain with his club side Bath for further assessment after he suffered a concussion against Leinster in the Champions Cup on January 22.

Scotland's update also confirmed Duhan van der Merwe and Kyle Rowe had joined up with the squad and that Sean Maitland, who was not selected by Townsend but was with the group, has returned to Saracens. 

After hosting England, Scotland face Wales in Cardiff and then welcome France to Murrayfield before taking on Italy. They round off their campaign against Ireland in Dublin on March 19.

Fabien Galthie provided an encouraging update on Antoine Dupont and Romain Ntamack after France's key duo tested positive for COVID-19 ahead of the Six Nations.

Les Bleus' preparation for the tournament has been hard hit by a host of contracting coronavirus.  

Bernard Le Roux had to make 11 changes to his 42-man squad, with World Rugby Player of the Year Dupont, fly-half Ntamack and Bernard Le Roux among those who were unable to report for international duty.

Galthie on Wednesday revealed the absentees due to COVID-19 are recovering well ahead of his side's opening game of the tournament against Italy at Stade de France a week on Sunday.

The France head coach said: "We keep in touch with all the players from afar, of course.

"We have good news concerning the players and their state of health and spirit and all are doing well."

Mercurial scrum-half Dupont has not played since December 11 due to a knee injury and coronavirus.

Galthie says the playmaker could return for Toulouse in their Top 14 encounter with Racing 92 on Saturday.

"I have spoken to him: he is doing well. He resumed training two weeks ago," said Galthie 

"He wanted to play against Cardiff but the match did not go ahead. Then of course he tested positive for COVID. But he is fine, and is still training. Today he had a test at his club and depending on the results he will play or not for Toulouse this weekend.

"That is up to his head coach Ugo Mola and I have confidence in him he will take the right decision both for his team and for Antoine."

It is 12 years since France won the Six Nations, but they are favourites to end that title drought this time around and that is music to Galthie's ears. 

"I am very happy with this compliment, we’re very happy and proud to be labelled as favourites," he said.

"We are very happy to hear all those positive comments. It's very rewarding, it's rewarding for our two-year work, it's rewarding for all the commitment of the players, the virtues of the team and their dedication on the pitch."

Wayne Pivac has not totally ruled out of the prospect of Alun Wyn Jones making another astonishing early return from injury to play for Wales in the Six Nations.

Jones was not included in the defending champions' squad last week as he recovers from shoulder surgery.

Dan Biggar was named captain for the tournament in the absence of the inspirational lock, who did the damage in a 54-16 thrashing against New Zealand in October.

Jones incredibly recovered from a dislocated shoulder to skipper the British and Irish Lions in South Africa last year.

Wales head coach Pivac says Jones is unlikely to play in the Six Nations, but there is a chance the 36-year-old could feature.

"Never say never," Pivac said, adding: "It's Alun Wyn Jones. I probably wouldn't enter the conversation if it was anyone else, but the guy has broken so many records.

"I honestly say that, I would never say never. But look, it'll be a long shot. Let's just say that.

"Al is working incredibly hard behind the scenes, as you know he would, to get himself in the best shape possible for either the Ospreys or Wales."

Stand-in captain Biggar echoed Pivac's sentiments as the holders prepare for their opening match against Scotland at Murrayfield on February 5.

"I wouldn't put my mortgage on it," the fly-half said.

"I don't think any of us expected [Jones] to turn up in South Africa in the summer, and he managed to get on the plane.

"If there is anybody who has got a chance of being fit for some part of this tournament, then Al is probably the man. I wouldn't rule it out just yet."

England captain Owen Farrell will miss the 2022 Six Nations after suffering a new ankle injury, head coach Eddie Jones confirmed.

The 30-year-old required surgery after damaging his right ankle during training with club side Saracens, who confirmed on Wednesday he will be sidelined for eight to 10 weeks.

Farrell has not played since another ankle injury sustained during the November Test victory over Australia at Twickenham.

The news is a significant blow to Jones' plans, with Farrell having been earmarked to play at number 12 and act as a guide for inexperienced fly-half Marcus Smith.

"Owen has had his operation, so he'll be out of the Six Nations," Jones said.

"[It is a] massive blow for him personally, but it's a chance for people to step up. It's an opportunity for other people to fill those leadership roles and an opportunity for other players to play for that number 12 jumper.

"In today's rugby, it's rare that you have all your best players on the field. We're used to it.

"Last night we had to leave the hotel because of a fire outside, so the boys are adaptable. They know how to get along with things and there's an opportunity there to build a little more leadership depth."

George Ford had already been recalled to the squad following injuries to Farrell and Jonny May, who has a knee problem.

England's preparations for the clash in Glasgow were further disrupted by a positive COVID-19 test for Joe Marler, while Courtney Lawes – among the favourites to deputise for Farrell as captain – has been sitting out training because of head injury protocols.

The team were also evacuated from their hotel in Brighton after a suspected electrical fire nearby.

England begin their campaign against Scotland at Murrayfield on February 5 before facing Italy in Rome a week later.

England suffered a blow to preparations for their Six Nations opener against Scotland after Joe Marler tested positive for COVID-19, while a fire near the team hotel also caused disruption.

Eddie Jones is readying his side for the Calcutta Cup tussle at Murrayfield on February 5, as England bid to improve on last season's disappointing Six Nations performance.

The Red Rose finished fifth in the tournament after just two wins, and preparations for this year's edition have been hit by injury, with captain Owen Farrell set to miss the Scotland game.

Courtney Lawes – initially one of the favourites to deputise as captain – is sitting out training this week because of head injury protocols. Nick Isiekwe has joined up with the squad as cover for Lawes, while George Ford has also been added, and it was revealed on Monday that Elliot Daly is in for Jonny May, who is out with a knee injury.

England announced a fresh blow, with a team statement saying: "Joe Marler has tested positive for COVID and has withdrawn from the training camp in Brighton. All of the other England players and staff have undergone daily lateral flow testing – all of which returned negative results."

England are training in Brighton this week; however, a suspected electrical fire close to their seafront hotel on Tuesday caused the team to seek alternative accommodation, with a 30-metre cordon enforced and nearby premises evacuated.

George Ford is back in the England squad ahead of the upcoming Six Nations as Eddie Jones awaits an update on captain Owen Farrell, but Jonny May is out.

Farrell has endured an injury-hit season so far and suffered a setback in training last week, with his club Saracens revealing he was set to see a specialist about the unspecified issue.

While he is all but ruled out of the Six Nations opener against Scotland on February 5, England are yet to confirm if Farrell can return after the Calcutta Cup clash.

Nevertheless, Ford is back in the selection to make up for Farrell's absence against Scotland, with the Leicester Tigers fly-half seemingly set for his 78th cap.

Ford has not played for England since the 32-18 Six Nations defeat to Ireland last March, with Marcus Smith's emergence nudging him down the pecking order, but he has the chance to stake his claim once again.

Also in Monday's squad update, England confirmed May has withdrawn from the squad with a knee injury, while Courtney Lawes – initially one of the favourites to deputise as captain in Farrell's stead – must sit out training this week because of head injury protocols.

Nick Isiekwe has joined up with the squad as cover for Lawes, while Elliot Daly is in for May.

George North still believes he could feature for Wales at the back end of the Six Nations as he prepares to return from a gruelling knee injury lay-off.

The star back, who has successfully converted from wing to outside centre with Wales, has the most international tries of all current players in the world game.

However, an anterior crucial ligament (ACL) blow has put his career on hold. Sustaining the injury last April forced North to miss the British and Irish Lions' tour of South Africa, plus the autumn internationals.

He was not included in Wales' 36-player squad for the Six Nations this week, absent along with several other notable injury casualties, including captain Alun Wyn Jones.

Champions Wales start their Six Nations defence against Ireland in Dublin on February 5, a date which has come much too soon for North to be considered. His short-term priority is getting in shape with his club side, the Ospreys.

"Hopefully I'll be back into some sort of team training next week," North told Stats Perform.

Asked whether there was any hope of him being available to Wales during the championship, North said: "There's two big steps: getting back to training full time with the Ospreys, then playing for the Ospreys with a view to potentially, maybe, catching the end of it.

"But at the moment I'm just focusing on playing back for the Ospreys."

Wales have home games against France and Italy on March 11 and 19 to finish the campaign, and North may be pushing for selection by then.

He has been a key component of the Wales team since making his debut as a teenager, and passed 100 caps during the Six Nations last year.

The 29-year-old has been itching to get back into action, but his absence from the pitch has allowed North some valuable family time.

He married Olympic cyclist Becky James in 2019, and they had a second son, Tomi, in October of last year.

North describes his wife as "a superstar" for helping him through a difficult rehabilitation period, and the former Northampton and Scarlets star is relishing his return to action.

"I take great confidence in knowing a load of rugby boys that I know have had single or double ACLs and they're still playing now, with no issues," North said.

"Luckily, I'm in a good generation where the medical care is advancing so quickly, so I'm benefiting from that. For me now, the focus is just to get back.

North, who is a Land Rover ambassador, is evidently relieved to be finally "on the home straight", as he puts it. He compares his current routine to that of a demanding pre-season, with full contact training still to come.

"I'm finding already this is the most frustrating part," he said, "because obviously you're a lot closer than you were six months ago."

He can only encourage his Wales colleagues from a distance as the Six Nations looms, and with the likes of Taulupe Faletau, Leigh Halfpenny, Josh Navidi, Ken Owens and Justin Tipuric also sidelined, it will be a challenging campaign for coach Wayne Pivac. North prefers to look at the positives that might come from this testing time.

"With adversity, you get exciting results," said North, "and the younger boys coming through that we've picked are exciting boys, and I'm excited to see how the boys come together to push on.

"Any Six Nations is tough. Obviously, you want your main team out there the best you can, and injuries are a nightmare for any team."

:: George North is a Land Rover ambassador. Visit landrover.co.uk

England captain Owen Farrell is a doubt for the Six Nations after suffering an injury in training.

The versatile Farrell has not played since November after undergoing ankle surgery he required due to damage done during a 32-15 victory over Australia at Twickenham.

Farrell was due to feature for Saracens in their European Challenge Cup clash with London Irish on Sunday, but the 30-year-old has suffered another setback.

Sarries said in a statement: "Owen was back in full training having recovered from the ankle injury he sustained against Australia during the Autumn internationals. 

"We will have a further update after he sees a specialist early next week."

Farrell's place in the England side has been called into question, but Eddie Jones this week firmly backed his skipper after naming his squad for a Six Nations tournament that the Red Rose start against Scotland at Murrayfield on February 5.

"We believe Owen can get into his best form very quickly and we believe he will be right to play against Scotland," the England head coach said.

“We are hopeful he's going to play this weekend. He has got a good training week with us next week and we will know whether he is right to play. We will just have to wait and see how he goes over the next couple of weeks.

"He's the best person to captain the team. Very clearly, he's the best person in my judgement to captain the team.

"If he's fit and eligible for selection, he will captain the team. If he's not then we will make an adjustment to that."

Courtney Lawes would appear to be the most likely player to take over as captain after leading his country in a win over South Africa in the absence of Farrell.