It says a lot about how far the flawless Arizona Cardinals have come that they found plenty to critique even after a 31-5 victory over the Houston Texans.

At 7-0 after routing the Texans on Sunday, the Cardinals are the NFL's lone unbeaten team and are off to their best start since 1974. 

For a team that have not won more than eight games in a season since their last trip to the playoffs in 2015, the Cardinals are brimming with confidence heading into a Thursday game against the 6-1 Green Bay Packers.

While quarterback Kyler Murray said he "wasn't too concerned" when the Cardinals came up empty on their first three offensive possessions – which included Arizona star being caught in the end zone for a safety – he noted they cannot make a habit of it. 

"I don't know why, maybe came out a little lax," Murray told a news conference. "I just know we've got to be better, because you get beat if you come out too slow. Sometimes you may not be able to catch up.

"So for us, I know we're better than what we put out there today. We kind of clicked, for the most part, during the middle of game but [Houston] got after us today. I don't want to take anything away from them. Obviously we won by large lead but for the most part offensively, I think, we can be a lot better."

Murray followed up that safety by leading a 14-play touchdown drive that got the Cardinals on the scoreboard and they did not look back from there, leading 17-5 at the half before tacking on two more TDs after the interval. 

Arizona's slow start may also have been attributable to head coach Kliff Kingsbury's return to the sidelines after missing the previous game against the Cleveland Browns following a positive COVID-19 test. 

While the Cardinals had no trouble in that 37-14 blowout, Kingsbury said it took him a while to find his rhythm against the Texans after missing the entire week of practice before he was cleared to coach in the game on Sunday. 

"I felt a little disconnected," he said. "I didn't feel as into the game as I usually am, just showing up on game day, but the players are awesome, great energy and made me feel very welcome to be back."

Murray said he did not pick up on his coach's discomfort but noted that it did not seem to be detrimental. 

"I'm sure he probably felt a little bit off, but we put up 31 today, defence played great," Murray said. "It was a great team win so for him to feel awkward or whatever and then we still put up 31 is a good job and you know we've got to keep it going because the Packers are coming in as a great team."

In his first game with the Cardinals after being acquired from the Philadelphia Eagles, Zach Ertz caught a 47-yard touchdown from Murray – his longest TD of his career.

Ertz also became the first player in NFL history with a receiving touchdown in consecutive weeks for two different teams.

Tom Brady expressed his gratitude after the Tampa Bay Buccaneers superstar celebrated another milestone in the Super Bowl champions' crushing win over the Chicago Bears.

Brady became the first player in NFL history to throw 600 touchdown passes as the Buccaneers routed the Bears 38-3 on Sunday.

The record seven-time Super Bowl champion finished the game with 602 TD passes, having completed 20 of his 36 passes for 211 yards and four touchdowns.

Brady also tied Drew Brees for the most games with at least four touchdown passes after reaching 37.

"I just think of all the guys that are sharing it with me," Brady told reporters as the Buccaneers reached 6-1 – their best start in franchise history. "That's the reality. There's nothing about this sport that you do by yourself.

"It's the ultimate team sport. It challenges you physically, mentally, emotionally, every week, every day at practice – this is not a sport you can just mail it in.

"It takes 100 per cent of what you have every single day to be successful and I'm just grateful to have amazing team-mates, coaches, to be able to do it for as long as I have is a really incredible blessing in my life.

"I have great family. I've got my little baby girl, who's the biggest cheerleader in the world and her two brothers, who are great cheerleaders and mom who was out there today rooting ... great to have the family here and to win a football game feels really good."

Having moved to 599 TD passes on a four-yard toss to Bucs team-mate Chris Godwin, Brady connected with Mike Evans for a nine-yard score, although the latter was clearly unaware of the historical significance of the play.

Evans gave the ball to a fan in the crowd, leading to a member of Tampa's equipment staff negotiating with the spectator to ensure its return, with the ball likely headed to the Hall of Fame in Canton, Ohio.

"That was really cool," Brady told reporters. "I got it in the bag over there. Mike gave it away. He goes, 'Man, I'm sorry, man. I'll get it.' I said, 'It's alright. I'm sure they'll find a way to get it back.'

"But I don't actually keep too many things so ... in that circumstance, I just felt like that might be a good one to keep."

"[The fan is] gonna get something nice in return. So we'll get him a helmet or a couple jerseys or some other stuff. That was really cool of him to do that."

Carolina Panthers head coach Matt Rhule vowed to stick with Sam Darnold as his starting quarterback, despite benching the team's top offseason acquisition in a 25-3 defeat to the New York Giants. 

Darnold completed 16 of 25 passes for 111 yards with no touchdowns and an interception and also was sacked three times in the NFL on Sunday.

His intentional grounding penalty in the end zone gave the Giants a safety for their first score of the game. 

Rhule handed the reins to backup P.J. Walker in search of a "spark" early in the fourth quarter, but he was even less effective, connecting on just three of 14 attempts for 33 yards. 

With the NFL's trade deadline looming on November 2, The Athletic reported following the game that the Panthers are expected to engage the Houston Texans in talks about acquiring Deshaun Watson. 

Watson requested a trade following last season and has not played this year after accusations of sexual misconduct surfaced during the offseason.

The 26-year-old quarterback has denied the allegations and remains on Houston's 53-man roster but has been inactive for every game. 

Reports last week said the Miami Dolphins and Philadelphia Eagles also were potentially interested in Watson, who has the right to veto any deal. 

Rhule was asked directly about potential interest in Watson on a conference call last week and responded that Darnold was his focus and "I'm not looking anywhere else". 

He maintained his line after the loss to the Giants, despite the Panthers dropping their fourth straight game following a 3-0 start – a slump that has coincided with star running back Christian McCaffrey being out of the line-up due to a hamstring injury. 

"Sam will be our quarterback next week," Rhule said. "He will be our quarterback moving forward.

"We're not winning right now. It's going to take all of us. [Darnold] just needs a lot of help from a lot of guys right now that he's not getting. I see the good moments, too. We're going to keep coaching him."

New York Jets rookie quarterback Zach Wilson appears set to miss at least a few weeks after injuring his right knee in Sunday's 54-13 loss to the New England Patriots. 

The Jets said Wilson – the second overall pick in this year's NFL Draft – hurt his posterior cruciate ligament (PCL) and will have an MRI exam on Monday. 

Wilson got hit by Jets linebacker Matt Judon on a pass attempt early in the second quarter. The Jets trailed 17-0 at the time and backup Mike White came in to lead New York to a touchdown, but the Jets would trail 31-7 by half-time. 

Jets head coach Robert Saleh said the Jets "feel good" about Wilson's prognosis based on the initial examination but will have to wait for the MRI to know more. 

Wilson told reporters he "felt a pop" as his knee got twisted on Judon's hit but said his knee did not hurt after the game. 

"I don't know a lot about the PCL," Wilson said. "The pain really isn't there. It's just feeling like something is a little off as far as being loose and unstable."

While Wilson said he considered a PCL injury the "best-case scenario" compared to an anterior cruciate or medial collateral ligament problem, expectations are he will need some time to recover. 

The 1-5 Jets host the high-flying Cincinnati Bengals (5-2) on Sunday. 

Wilson has completed 57.5 per cent of his passes for 1,168 yards with four touchdowns and nine interceptions, the latter tied with Patrick Mahomes for the most in the NFL. 

Tom Brady made history once again as Super Bowl champions the Tampa Bay Buccaneers rolled past the Chicago Bears 38-3 in NFL action Sunday. 

With a nine-yard strike to Mike Evans in the closing seconds of the first quarter, Brady became the first NFL quarterback to throw 600 touchdown passes.

The 44-year-old – 20-of-36 passing for 211 yards – would finish the game with 602 for his career, all four of his TD tosses going for fewer than 10 yards and three of them landing in Evans' hands. 

Blaine Gabbert took over at quarterback for Brady midway through the fourth quarter with the game well in hand as the Buccaneers improved to 6-1. 

Brady's opposite number, Bears rookie QB Justin Fields, had a brutal day as he was sacked four times and threw three interceptions as Chicago failed to find the end zone. 

Stafford, Rams survive Lions scare

The matchup between Super Bowl contenders the Los Angeles Rams and the winless Detroit Lions finished with the expected result, but the Rams' 28-19 win was much closer than anticipated. 

The Rams (6-1) trailed 19-17 entering the fourth quarter and needed a five-yard touchdown pass from Matthew Stafford to Cooper Kupp early in the period to take the lead and a 47-yard Matt Gay field goal with just over a minute to play to seal the win. 

Stafford completed 28 of 41 passes for 334 yards and three TDs against the team he played for in the first 12 years of his career, while former Rams QB Jared Goff threw a pair of costly interceptions for the Lions (0-7).

Kupp became the first player in the Super Bowl era to have 800-plus receiving yards and nine-plus receiving touchdowns in his team's first seven games of a season.

While the Lions remained the only winless team in the league after Week 7, the Arizona Cardinals (7-0) maintained their status as the lone team with a perfect record, routing the Houston Texans 31-5 behind three TD passes by Kyler Murray. 

After another disastrous outing, at least the Kansas City Chiefs can take solace in knowing Patrick Mahomes does not appear to have been seriously injured in Sunday's 27-3 loss to the Tennessee Titans – but all is not well, either. 

The Chiefs' star quarterback left the game midway through the fourth quarter after taking an inadvertent shot to the head from Tennessee's Jeffery Simmons while being dragged down by Denico Autry. 

Mahomes did not return to the game, as Chad Henne took the reins for Kansas City's final possession, but Chiefs head coach Andy Reid said Mahomes cleared the NFL's concussion protocol and it was his decision not to send him back into the lopsided game. 

The most prominent indicator that Mahomes does indeed "feel fine" as he told reporters post-game was that he spoke to the media at all. If he was still in the concussion protocol he would not have been compelled to do so. 

"Y'all saw the hit," Mahomes said. "I took my time getting up, but I felt fine. I did everything I needed to do to be here."

The overriding question now is what Mahomes and the Chiefs can do to get back on track moving forward.

Since Mahomes took over as Kansas City's starting quarterback for the 2018 season, the Chiefs have never lost more than four regular-season games. Sunday's ugly defeat dropped them to 3-4. 

While Mahomes was hardly the only man at fault, he turned in one of the worst games of his career, including an all-time low 62.3 passer rating. 

He also lost a fumble and threw his ninth interception of the season, tying him for the league lead. He threw just 11 interceptions across 29 games over the last two regular seasons combined. 

"Today, it was probably me," he told reporters. "Just pressing a little bit too early in the game. And then we got down, and we were in that mode where you’re no-huddle, which you don’t want to be in the NFL. You can execute it a little bit, but it’s hard to sustain drives."

The pressure of defending their AFC title appears to have been a strain on the Chiefs in general and Mahomes in particular. Sunday was the second game in his NFL career in which he did not lead a touchdown drive, the other being the 31-9 Super Bowl loss to the Tampa Bay Buccaneers in February. 

"I want to win," Mahomes said. "At the end of the day, I want to win. So I try to do whatever I can to win. But you have to believe in the guys around you. You have to know you can go the long way. You can take a short pass, and guys will make guys miss. You can hang in the pocket and make throws. "

"But at the end of the day, I just want to win. Whatever that takes, I’m going to try to do. I’ll look at this film, learn from it, and try to come out better Monday night this week."

Another week, another piece of history for Tom Brady, who became the first player in NFL history to throw 600 touchdown passes in the Tampa Bay Buccaneers' clash with the Chicago Bears.

Brady went into the Week 7 contest needing two touchdown throws to reach this latest milestone in his remarkable career.

Just before the end of the first quarter, the seven-time Super Bowl champion had the record on Sunday.

Having moved to 599 on a four-yard toss to Bucs team-mate Chris Godwin, Brady connected with Mike Evans for a nine-yard score, although the latter was clearly unaware of the historical significance of the play.

Evans gave the ball to a fan in the crowd, leading to a member of Tampa's equipment staff negotiating with the spectator to ensure its return, with the ball likely headed to the Hall of Fame in Canton, Ohio.

Brady will also one day have a place in Canton but, for now, the 44-year-old superstar is engaged in the process of yet more legacy padding.

He found Evans for two more touchdown throws before half-time to give Tampa Bay a 35-3 lead at the break, defending Super Bowl champions the Buccaneers looking near-certainties to move to 6-1 as Brady seeks his eighth Lombardi Trophy.

Even in an age where the passing game is king, the best teams in the NFL can still fall victim to a dominant rushing performance.

Derrick Henry proved as much on Monday Night Football in Week 6, putting the Buffalo Bills to the sword with a 143-yard, three-touchdown performance as the Tennessee Titans claimed a thrilling primetime win.

It was Henry's fifth successive 100-yard game and his third this season with three touchdowns.

Unsurprisingly, the man who has won the rushing title in each of the last two seasons again leads the league in yardage on the ground.

More noteworthy, however, is the fact Henry is on pace to comfortably break Eric Dickerson's record for most rushing yards in a single season.

Dickerson's mark of 2,105 has stood since 1984, but Henry critically has the benefit of a 17th game in which to make NFL history.

But is Henry's pace sustainable? And, beyond writing one of the most incredible chapters in the NFL record books, what would it mean if Henry does surpass Dickerson?

Henry's potentially historic average

Following his dominant showing against Buffalo, Henry is averaging 130.5 yards per game, putting him on track for 2,219.

Such a gaudy average would be unsustainable for most backs. However, Henry has the exceptional skill set to again prove as the exception.

He finished last season with similar numbers, putting up 126.7 yards per game while leading the league with 378 carries – Dalvin Cook was second with 312 –  as the Titans star surpassed 2,000 for the first time in his career.

And his frightening combination of his size and speed has allowed Henry to display durability beyond most players at his position.

Henry has missed only one game across the previous two seasons, a period in which he carried the ball a league-high 681 times, with his 6ft 3in and 247lb frame and his explosiveness ensuring it is opposing defenders who typically come off worst in collisions.

A favourable schedule

Speaking to that explosiveness is Henry's 2021 yards before contact per attempt average of 3.01. That figure is comfortably above the league average of 2.40 and the difficulty in stopping Henry once he bursts to the second level of the defense is reflected by his number of big-play runs.

Henry leads the league with 19 rushes of 10 yards or more while he is the only player in the NFL with two runs of at least 50 yards.

Simply put, being in the path of this behemoth when he breaks into the open field is the most difficult position for an NFL defender to be in, and he will face plenty of defenses vulnerable to run during the remainder of the season.

On Sunday, the Titans face a Kansas City Chiefs defense ranked 30th in rush yards per attempt allowed (5.15), with six of the last 11 weeks of the season seeing Tennessee meet a team ranked in the bottom half of the league by that metric.

The blend of Henry's proclivity for big gains and a schedule that should present a plethora of opportunities for displays akin to his devastating effort in Week 6 is a perfect recipe for the former Alabama star sustaining his current pace and shattering Dickerson's record, which would be significant for several reasons.

Destined for Canton?

The magnitude of Henry breaking the rushing record cannot be overstated.

At present, it is only the advent of the 17th game that would make his current pace enough for him to surpass Dickerson, who averaged an astonishing 131.6 yards across 16 games.

Yet that would not detract from the scale of Henry's achievement, with that potential piece of history standing as a monument to his consistency.

In addition to claiming a record that has long since seemed unbreakable, Henry would become the first player in NFL history to record multiple 2,000-yard seasons, doing so in successive years.

Putting that into context, no player in NFL history has even posted back-to-back 1,900-yard seasons, with Dickerson the sole player to go over 1,800 yards in consecutive years, his record-breaking 1984 following a 1983 campaign he finished with 1,808 yards as a rookie.

Henry may only be in his sixth season as a pro but, should he maintain his pace and make NFL history, he can surely look forward to a place in the Hall of Fame.

The argument could be made that he would require a longer spell of dominance to secure a spot in Canton. However, Henry is on course for an unmatched two-year run at a time where the unstoppable bell-cow running back is considered a thing of the past.

This is the era of committee backfields, one where any running back taken in the first round can be viewed as a reach, and yet Henry is producing at an unprecedented rate amid a workload that would physically break many tailbacks and carrying the Titans to victories that have helped establish a two-game lead in the AFC South as they look for back-to-back division titles.

Tennessee's flaws on defense will likely prevent the Titans from seriously contending for a deep playoff run this year, but Henry has the distinct opportunity to make sure this season is memorable for entirely different reasons that would be worthy of him being immortalised and receiving a gold jacket after an increasingly astounding career comes to a close.

The Indianapolis Colts appeared destined for a lost season back in Week 3.

Indianapolis started the year with three successive defeats and the Colts' gamble on their ability to revive Carson Wentz's career looking misjudged.

Since then, the Colts have enjoyed wins over the Miami Dolphins and Houston Texans, sandwiched by a heartbreaking defeat to the Baltimore Ravens in which they let slip a 19-point lead and lost in overtime.

The performances in those last three games have led to renewed optimism around a team that has reached the playoffs in two of the last three seasons.

Should Indianapolis knock off the San Francisco 49ers on the road in primetime, then the hype around the Colts will only grow.

Yet the 49ers figure to prove a difficult matchup for a quarterback whose performances in recent weeks have perhaps been slightly overrated.

Sub-par accuracy

Ninth in the league in yards per attempt (8.01) and with nine touchdowns to one interception, the numbers through six games for Wentz are impressive.

Yet his completion percentage is 64.2, 21st among 32 qualifying quarterbacks and that is reflected by his accuracy numbers.

Wentz, per Stats Perform data, has produced an accurate, well-thrown ball on 77.7 per cent of his passes, below the league average of 78.8 for quarterbacks with at least 10 attempts.

And he is set to face a Niners defense that has once again been among the league's best this season.

An intimidating defensive line

While the 49ers are themselves an underwhelming 2-3 and riding a three-game losing streak, their defense is excelling under new coordinator DeMeco Ryans.

The 49ers rank sixth in the NFL by yards per game allowed (329.8) and eighth in yards per play (5.29) and, while they are 30th in the NFL with only 76 pressures, they boast defensive linemen who can get Wentz out of rhythm.

Defensive tackle Arik Armstead and edge rushers Nick Bosa and Dee Ford have each dominated in 2021 when it comes to winning their individual matchups.

Armstead has a stunt-adjusted win percentage of 52.63 from his 49 pass rush matchups this year. Ford is next on 45 per cent while Bosa has an adjusted win percentage of 41.54 from 60 matchups. The league average for defensive linemen is 22 per cent.

They will each look to prosper against a Colts offense that has allowed the ninth-most pressures in the NFL (105) while the numbers suggest the Niners should excel at limiting the explosive plays on which Wentz has found joy in recent weeks.

Big plays not a guarantee

On passing attempts of 21 or more air yards, Wentz has the highest passer rating in the NFL (144.7).

He has completed 11 of 18 such attempts for 377 yards and three touchdowns and showed off his deep-ball prowess during last week's rout of the Texans.

Wentz hooked up with Parris Campbell for a 51-yard touchdown and connected with T.Y. Hilton for a 52-yard reception; however, such plays are partially a reflection of the struggles of a Texans defense allowing 7.6 yards per pass play.

The 49ers, despite a spate of injuries to their cornerbacks, have allowed 43 pass plays of 10 yards or more, the fewest in the NFL. San Francisco's defense has conceded 16 pass plays of 20 yards or more, the seventh-fewest in the league.

Wentz, therefore, may be forced into a more conservative approach in a game expected to take place in inclement weather. Helpfully, he may be able to lean more on the running game, with San Francisco 16th in yards per rush allowed (4.26) and running back Jonathan Taylor fifth in the NFL in yards per carry (5.43) for players at his position as he enjoys a superb start to his second season.

Indianapolis' signal-caller can also afford to at least have confidence in his ability to avoid turnovers. His pickable pass percentage of 1.68 is the fourth best among quarterbacks with a minimum of 10 attempts and the 49ers have a league-low two takeaways to their name.

A closer look at the evidence from his reunion with Colts coach Frank Reich indicates Wentz might find success difficult on Sunday should the Colts need to win the game on his arm. If he contradicts the statistics and thrives against a tough defense on the road, then the optimism around Indianapolis will be more justified.

The Tampa Bay Buccaneers will be without Antonio Brown, Rob Gronkowski and Lavonte David when they face the Chicago Bears this Sunday.

Defending champions Tampa Bay look bound for another deep playoff run, the Bucs having started the year 5-1.

However, they will have to cope without a clutch of stars against the 3-3 Bears, with tight end Gronkowski (ribs) set to miss a fourth successive game.

Brown, who leads the Bucs with four receiving touchdowns, has an ankle injury, as does linebacker David, a second-team All-Pro last year.

Cornerback Richard Sherman (hamstring) is out, but the Buccaneers will receive a boost with secondary Antoine Winfield Jr. available having passed through the NFL's concussion protocol.

The Bucs have started 5-1 for the fifth time in franchise history, having made the playoffs in each of the previous four seasons (2005, 2002, 1997 and 1979).

Tampa Bay will look to go 6-1 for the first time, but head coach Bruce Arians is not underestimating the Bears and rookie quarterback Justin Fields.

"Real good week of practice, and obviously this is a team that I think is on the rise," Arians said. "It's going to take our best to make sure we beat them."

Tua Tagovailoa has received public backing from Miami Dolphins head coach Brian Flores as rumours over a trade for Houston Texans quarterback Deshaun Watson intensify.

A report this week in the Houston Chronicle suggested the Dolphins were on the brink of completing a trade for Watson with the Texans.

Watson is rated among the elite QBs in the NFL after a fantastic 2020 season but has not been active for any games this season.

The 26-year-old requested a trade from the Texans in January and is facing 22 civil lawsuits that remain unresolved as the NFL conducts its own investigation into sexual assault and misconduct allegations against him.

Tagovailoa, meanwhile, has had a difficult second season, missing three games with fractured ribs while the Dolphins, who had playoff ambitions, collapsed to a dreadful 1-5 start.

The former Alabama standout returned to action in London last week but could not prevent the Dolphins going down to defeat against the previously winless Jacksonville Jaguars. 

Their hopes of a successful season therefore look bleak ahead of Sunday's must-win home game with the 2-3 Atlanta Falcons.

A change at the QB position has been mooted, but when he was asked about the Watson reports on Friday, Flores replied: "I don't really get into rumours - Tua is our quarterback.

"We're happy with the quarterback, our quarterback situation. I'll leave it at that, which I've said multiple times."

Tagovailoa threw for 329 yards, two touchdowns and one interception against the Jaguars after completing 33 of his 47 pass attempts.

"I thought he played very well last week," added Flores. "His preparation, the way he practices and the way he performs has been good.  

"I think his psyche is in a good place. He's a confident kid, he's a tough kid. He's played in two games this year so he should have a lot of confidence in the way he's played. 

"We have a lot of confidence in him. He's developing, I think this kid is smart, he's talented, he's accurate, I think he definitely has the opportunity to be a very good NFL player. 

"There's always bumps in the road for anyone in any career, any profession. You have to work through those and you become better for it."

Tagovailoa started nine games in his rookie season, winning six of them as he threw 11 touchdowns to five picks with some steady but unspectacular performances.

In 2020 he was battling for snaps with Ryan Fitzpatrick, but a clear path to the starting job emerged when the veteran moved on to Washington and Miami opted not to pick a QB in the draft.

Kyle Shanahan needs to get the San Francisco 49ers winning again if their playoff potential is to be fulfilled, and this Sunday looks like a major opportunity.

To snap a three-game losing streak, the Niners (2-3) must get the better of an Indianapolis Colts side who, much like San Francisco themselves, have made an inconsistent start to the season.

By contrast, the Tampa Bay Buccaneers are riding a three-game run of wins and have started 5-1 for just the fifth time in the history of the franchise, heading into a tussle with the Chicago Bears (3-3). Tom Brady has been a driving force so far as the Super Bowl winners carry on where they left off last season.

Patrick Mahomes has been hit and miss for the slow-starting Kansas City Chiefs, who will hope the NFL's highest-paid player can cut out throwing interceptions as they face the Tennessee Titans.


Indianapolis Colts @ San Francisco 49ers

If coach Shanahan's 49ers are to turn around their season, then facing a Colts side who have begun 2-4 seems like a pretty good place to start. Yet the Colts have dominated this series of late, winning on their last four meetings, albeit most recently in 2017 when they snatched a 26-23 overtime success. It would not be stepping out of line to predict this could be tight, given the 49ers have played nine consecutive games that have been decided by eight or fewer points, going back to last season.

That is the longest active streak of such close games in the NFL and the longest streak in team history, and the Niners do not have the best recent return when games go close, posting a 3-6 record in this sequence.

San Francisco fell 17-10 to the Cardinals in their most recent game, two weeks ago, while the Colts hot-footed their way to a 31-3 trouncing of Houston last Sunday. That came despite Indianapolis earning just 15 first downs for the entire game. It was the first time the Colts had won by 28 or more points while only having 15 or fewer first downs since 1972 against New England.

In his 21st career game, Colts running back Jonathan Taylor rushed for 145 yards and two touchdowns, meaning he surpassed 1,500 rushing yards, 500 receiving yards and chalked up his 15th rushing touchdown in the NFL. Only four running backs in NFL history have hit all three of those milestones in fewer games than Taylor, with two of those doing so with the Colts – Edgerrin James and Marshall Faulk.

San Francisco will hope to be recharged after a bye week. Deebo Samuel scored the fourth rushing touchdown of his career against the Cardinals, with Jerry Rice (10) the only wide receiver with more rushing touchdowns in 49ers history.

Chicago Bears @ Tampa Bay Buccaneers

After a dispiriting loss to the Green Bay Packers last time out, the Chicago Bears encounter a Tampa Bay team in sparkling recent form. Tampa Bay have started the season 5-1, doing so for the fifth time in franchise history, and on each of the previous occasions (2005, 2002, 1997 and 1979) they backed it up by reaching the playoffs. History could be made on Sunday, given the Buccaneers have never started a season with six wins through their first seven games.

Yet this is a game in which the Bears have traditionally, and recently, had the upper hand. Chicago have stacked up 40 wins in 60 all-time meetings against Tampa Bay, which is the most wins by any team against the Bucs. The Bears have also won the last two in the series, scoring victories in 2018 and 2020.

Tampa Bay can seemingly do no wrong when Brady is pulling the strings so masterfully. Brady leads the NFL with 2,064 passing yards, the second-highest total he has ever had through six games of a season – beaten only by his 2,163 passing yards at this stage in 2011. Prior to this year, no Tampa Bay quarterback had ever thrown for more than 1,800 yards through six games.

What have the Bears got to offer? Chicago are averaging 246.2 net yards per game, which is more than 20 yards per game less than any other team. The 1,477 yards is the fewest Chicago has had through six games since the 1993 season. Rookie quarterback Justin Fields needs to make something happen, but others must step up too. In his first career start, Khalil Herbert ran for 97 yards and a touchdown against Green Bay last time out.

Kansas City Chiefs @ Tennessee Titans

"He's trying to make things happen," said Chiefs head coach Andy Reid, explaining away the two interceptions thrown by Patrick Mahomes in Week 6 against Washington. For Mahomes, that was a second straight game with at least two interceptions. He is tied with Jacksonville's Trevor Lawrence in second position on the list of the most interceptions thrown this season, with his tally of eight so far only topped by Zach Wilson of the Jets.

This is only the second run that Mahomes has endured of throwing two or more interceptions in consecutive games, the previous dating back to Week 5 and 6 of the 2018 season, and Reid will hope his radar is better set for the clash with the Titans. Mahomes is still doing an awful lot right in 2021, but the fact remains he threw just six interceptions last season.

The Chiefs' unsteady 3-3 opening is their worst of the Mahomes era, and it was 2015 when they got off to a slower start. On that occasion they followed a 1-5 opening with 10 consecutive wins, a single-season record for Kansas City that was matched last season.

Tennessee's bright start has featured some notable performances. The Titans ran for 146 yards and scored four rushing touchdowns in the 34-31 win over Buffalo on Monday night, taking them to 985 rushing yards and 12 rushing touchdowns for the season. It is the first time in franchise history that the Bills have 10 or more rushing touchdowns and at least 975 rushing yards through six games.

Running back Derrick Henry has 10 rushing touchdowns so far, beating his career best of seven through six weeks in 2020. It puts him tied for the fourth most rushing touchdowns of all time through six weeks (Jim Brown 14, Shaun Alexander 12, Emmitt Smith 11).

Elsewhere...

The Detroit Lions face a tall order on the road against the Los Angeles Rams (5-1). Detroit are 0-6 for the first time since their 0-16 season in 2008 and have not scored more than 17 points in any of their last five games. Former Rams quarterback Jared Goff, now with Detroit, has thrown zero touchdown passes and an interception in each of his last two games.

The 5-1 Baltimore Ravens have recent history on their side ahead of a clash with the Cincinnati Bengals, having won five successive games in their head-to-head series, including the last three by a brutal average of 31.7 points.

Heading into a home game against the Houston Texans (1-5), the Arizona Cardinals are on a 6-0 roll. This has only happened twice before in franchise history, but never before in Arizona. The St Louis Cardinals in 1974 and Chicago Cardinals in 1922 are the teams who both started their seasons 6-0 as well.

Philadelphia QB Jalen Hurts could match an NFL record as the Eagles (2-4) tackle the Las Vegas Raiders. Hurts has rushed for two touchdowns in each of his last two games. Billy Kilmer, for San Francisco in 1961, is the only quarterback to achieve the feat in three straight games.

The Green Bay Packers last lost at home to Washington in 1988, winning five in a row since with home-field advantage, and they put a 5-1 season record to the test when the teams meet again. Washington (2-4) are yielding an NFL-worst 31.0 points per game in 2021, matching the team's worst mark through six games of a season in the Super Bowl era (1998).

Backup quarterback Case Keenum won the praise of Cleveland Browns head coach Kevin Stefanski after he led the team to a narrow and crucial victory over the Denver Broncos.

Cleveland emerged from Thursday Night Football with a 17-14 home win despite playing without injured starting QB Baker Mayfield.

Star running back duo Nick Chubb and Kareem Hunt were also ruled out, putting the Browns under huge pressure as they looked to rebound from consecutive losses to the Los Angeles Chargers and Arizona Cardinals.

Defeat could have left the Browns – who are targeting a postseason run in 2021 – floundering, but instead they improved to 4-3, as Keenum played a clean game with 199 yards, one touchdown and no turnovers and ran for a key redzone fourth-down conversion in the second half.

"Case fought like he always does," Stefanski said after Keenum claimed his first NFL win since 2019.

"I thought he orchestrated the operation. He took care of the football and that was a huge play in the end zone there on fourth down. 

"Just to make a play, fighting for extra yardage. He did a great job fighting."

D'Ernest Johnson stepped in for Chubb and Hunt to record 146 rushing yards and his first career touchdown, while the Browns' defense was impressive with Myles Garrett getting 1.5 sacks and John Johnson intercepting Teddy Bridgewater.

"Unfortunately, some people are going to get hurt," said Keenum. "At the same time, you love other young guys getting chances.

"I felt calm and poised. It was a great first drive there. Kevin put together a great first 15 and the offensive line did a great job.

"Defense played really, really well. To hold those guys to what they did in some pretty clutch moments was big.

"It feels pretty good, it was a lot of fun. We have a great group of guys and they fought their tails off."

Mayfield has a shoulder fracture and a torn labrum but still hopes to be back for the Halloween clash against AFC North rivals the Pittsburgh Steelers in Week 8.

For the Broncos (3-4), pass-rusher Von Miller will undergo an MRI scan on Friday due to an ankle injury he suffered after colliding with a team-mate in the second quarter.

But head coach Vic Fangio believes Miller has just suffered a sprain while the player himself said he thinks he has "dodged a bullet".

"My pride is hurt more than anything," said the former Super Bowl MVP.

The Cleveland Browns have snapped their two-game skid without Baker Mayfield with a 17-14 victory over the Denver Broncos in Thursday Night Football.

Browns running back D'Ernest Johnson stole the show in his first career start, scoring the first touchdown after only five plays and finishing the game with 22 carries for 146 yards.

Case Keenum, making his first Browns start in place of the injured Mayfield, completed 21 from 33 attempts for 199 yards including one touchdown pass.

The result improves Cleveland to 4-3, while it means the Broncos have lost four in a row, sliding to a 3-4 record.

The Browns led 10-0 at half-time after Chase McLaughlin's 52-yard attempt, before the Broncos rallied with Melvin Gordon diving in at the corner from Teddy Bridgewater's touchdown pass to narrow the deficit.

Keenum found Johnny Stanton with a short touchdown pass to restore Cleveland's 10-point lead in the third quarter.

The Broncos scored late from a 17-play drive as Bridgewater, who completed 23 from 33 attempts for 187 yards but had one interception, found Javonte Williams for his second touchdown pass of the game.

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