Erik ten Hag urged his players not to get complacent against a Burnley side who are still fighting for their place in the Premier League.
After a run of four games without a win in the top-flight, Manchester United came from behind with late goals from Bruno Fernandes and Rasmus Hojlund to beat bottom-of-the-table Sheffield United on Wednesday.
The Red Devils sit in sixth place on 53 points, three more than Newcastle United below them, but have not yet secured a place in Europe next season.
When asked what kind of challenge Burnley would pose, Ten Hag was full of praise for the way Vincent Kompany has set up his team.
“They play high-intensity football. They have changed their approach slightly in the season. They have had good results and are hard to beat, and all the compliments to Vincent and his staff.
“We can’t afford to think [it’s only X] about any opponent. With the team we have available, we have to be creative. We have to take every opponent with 100% focus. We can’t allow and do a little bit less.”
Burnley’s survival hopes were given a huge boost last weekend with an impressive 4-1 win against Sheffield United, leaving them just three points behind Nottingham Forest in 17th.
With just four games left of the season, Kompany highlighted the characteristics have kept the Clarets within touching distance of the teams around them.
He said: “The biggest thing is consistency, hard work and making sure to not get distracted by the outside noise has been the main factor. We haven't found the recipe for Champions League football yet, but we are improving every game.
"I know we still have a chance and that's all that matters to me, whether it's two teams, three teams or four teams still in it, it doesn't matter too much to me.”
Celtic 3-1 RB Leipzig: Kuhn double inspires Hoops to Champions League fightback
Celtic's Nicolas Kuhn scored twice as the Bhoys fought back to clinch an impressive 3-1 victory over RB Leipzig in the Champions League on Tuesday.
Coming off a goalless draw at Atalanta on matchday three, Celtic recorded their second home win in the Champions League this season, moving up to 13th in the standings on seven points.
They had to do things the hard way, falling behind to Christoph Baumgartner's close-range header after a corner came off Cameron Carter-Vickers in the 23rd minute.
However, Kuhn levelled in the 35th minute with a superb curling effort from the edge of the box, then tapped into an open net for his brace shortly before half-time.
Benjamin Sesko and Baumgartner went close to equalising after the break but Celtic's birthday boy, 38-year-old goalkeeper Kasper Schmeichel, pulled off a couple of fine saves before Reo Hatate sealed victory with a close-range finish in the 72nd minute.
Leipzig's wait for a first point in the Champions League this campaign continues, with their chances of reaching the knockout stages fading after four defeats in as many games.
Data Debrief: Celtic flying high
Celtic may have been humiliated in a 7-1 defeat to Borussia Dortmund on matchday two, but that was a mere blip in what has so far been an impressive European campaign.
Their total of seven points is already their most in a Champions League campaign since 2012-13, when they collected 10, while they last netted more goals (currently nine) in a Champions League/European Cup campaign in 1977-78 (13).
Borussia Dortmund 1-0 Sturm Graz: Malen late show extends Champions League home record
Donyell Malen netted an 85th minute winner to hand Borussia Dortmund a narrow 1-0 victory over winless Sturm Graz in the Champions League on Tuesday.
A dominant showing from Nuri Sahin's side made it three wins from four games so far in the competition, moving them up to fourth in the new 36-team league.
Dortmund started brightly at the Westfalenstadion but were unable to find a breakthrough, with Marcel Sabitzer, Maximilian Beier and Serhou Guirassy going close.
They recorded 13 shots in the first half, their most in the opening 45 minutes of a Champions League match without scoring since Opta recorded this data (since 2003-04).
But Sturm Graz offered a threat on the break after the interval, with Jusuf Gazibegovic curling an effort narrowly wide before Mika Biereth missed a header from close range.
However, Dortmund left it late to seal the win as Malen pounced on Emanuel Aiwu's loose pass before being sent through by Guirassy, with the Dutchman rattling the ball beyond
Kjell Scherpen to seal another Champions League home win.
Data Debrief: Home comforts
While Sahin has come under fire for Dortmund's displays away from home, there is no arguing with his record at the Westfalenstadion.
He became the first Dortmund coach since the Bundesliga was founded to win each of his first seven home matches in charge (all competitions), while BVB are now unbeaten in 13 consecutive Champions League home games (W9 D4) - an extended club record.
Malen’s winner was timed at 84:56, Dortmund’s latest winning goal in a Champions League match since Kevin Groskreutz netted against Marseille in December 2013.
Lille 1-1 Juventus: French side's resistance broken after second-half penalty
Lille held firm to hold Juventus to a 1-1 draw at home on Tuesday in the Champions League, extending their unbeaten run to nine matches.
Jonathan David had fired the French club ahead in the first half, before Dusan Vlahovic scored a second-half penalty to level things up and leave both sides on seven points after four matches.
Things didn't start well for the home side, with Teun Koopmeiners thinking he had scored the opener for Juventus only for it to be disallowed for offside.
David put Lille ahead just three minutes later with their first chance of note in the match. The Canadian turned home to convert from a slick counter-attacking move.
Goalkeeper Lucas Chevalier had to be on form to keep the home side ahead before half-time, sensationally saving a Vlahovic half-volley 10 minutes before the break. Koopmeiners, meanwhile, had another effort chalked off in the 42nd minute.
Juventus upped the pressure in the second half, with Chevalier also upping things and pulling off two impressive saves in quick succession.
But ultimately, the Lille resistance was broken by a Vlahovic penalty on the hour after Francisco Conceicao had been fouled by Benjamin Andre.
The result leaves Juventus 10th and Lille 12th in the Champions League table.
Data debrief: Lille looking good for qualification
After drawing 1-1, Lille are unbeaten in nine matches in all competitions and three matches in the Champions League.
The French side had beaten Atletico Madrid and Real Madrid in back-to-back European games.
They now have a seven-point buffer between themselves and the bottom eight in the league table.
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