Serena Williams will begin her Wimbledon challenge against French player Harmony Tan, who will be making her main-draw debut.

For 40-year-old American Williams, a seven-time Wimbledon singles champion, there will be relief at avoiding a seed in the first round.

That was a possibility given that Williams is in the draw on a wildcard, having not played singles since suffering an ankle injury in her Wimbledon opener 12 months ago.

Instead, the 23-time grand slam winner will face the world number 113, who lost in the first round of the recent French Open, perhaps as soft a landing as Williams could have had.

Wimbledon begins on Monday at the All England Club, with women's defending champion Ash Barty not involved after announcing a shock retirement in March.

Williams has returned to action this week at the Eastbourne International, winning through two rounds in doubles alongside Ons Jabeur, before the duo pulled out due to a knee worry for Jabeur.

Awaiting the winner of Williams versus Tan will be American Christina McHale or Spanish 32nd seed Sara Sorribes Tormo, while last year's runner-up Karolina Pliskova is a potential third-round obstacle.

Women's top seed Iga Swiatek starts against Croatian qualifier Jana Fett, while Britain's US Open champion Emma Raducanu was drawn to face the experienced Belgian Alison Van Uytvanck, a player who knocked out the then-defending champion Garbine Muguruza at Wimbledon four years ago.

Tunisian third seed Jabeur was paired with Swedish qualifier Mirjam Bjorklund, Pliskova faces fellow Czech Tereza Martincova, and American Coco Gauff, fresh from a first grand slam final in Paris, drew Romanian Elena-Gabriela Ruse.

Estonia's Anett Kontaveit, who may struggle to live up to her billing as the second seed having never previously gone past round three, plays American Bernarda Pera first up.

Among former champions, Angelique Kerber tackles Kristina Mladenovic in her opener, while Simona Halep was handed a tough assignment against Karolina Muchova.

Of all the players in the draw this year, Muchova is the woman with the highest winning percentage in Wimbledon main draw matches.

The Czech has an 80 per cent success record, winning eight matches and losing twice after reaching the quarter-finals in her both previous appearances, losing to Elina Svitolina in 2019 and Kerber last season.