Nick Kyrgios hopes he never has to face Thanasi Kokkinakis again after eliminating his close friend and doubles partner in the opening round of the US Open.

The Wimbledon runner-up began his latest quest for a maiden singles grand slam crown with a routine 6-4 6-4 7-6 (7-4) victory at Arthur Ashe Stadium on Monday.

It marked the first time the pair, who won the doubles event on home soil at the Australian Open in January, have met in a tour-level match.

Kyrgios will also partner Kokkinakis in the US Open doubles, and the 27-year-old did not enjoy facing his compatriot in singles competition.

"When we both saw the draw, it was a nightmare, honestly," Kyrgios said. "We never want to play each other. 

"I've just got so much respect for him. I can't wait to get out there and play doubles with him on the right side of the net.

"We just know each other's games like the back of our hand. We've played together since we were about nine years old. 

"He knows my game well. I know his game extremely well. I just played the bigger points well early on. We're going to play each other, hopefully, never again."

Kyrgios will now take on Benjamin Bonzi, who beat fellow Frenchman Ugo Humbert in five sets to advance at Flushing Meadows.