Alvin Kamara will sit out the New Orleans Saints' game against the Tennessee Titans on Sunday with a knee injury. 

Star running back Kamara did not practice on Wednesday, Thursday or Friday and will be absent for the crunch Week 10 matchup against the number one team in the AFC. 

The four-time Pro Bowler has rushed for 530 yards and three touchdowns in his eight appearances for New Orleans this season. 

His absence is another significant blow for head coach Sean Payton, with starting quarterback Jameis Winston and wide receiver Michael Thomas already sidelined for the rest of the campaign.

The 5-3 Saints are in with a decent shot of making the postseason but will have to bounce back from a 27-25 defeat to the Atlanta Falcons when they take on the 7-2 Titans. 

Trevor Siemian will again start at quarterback, having completed 25 of his 41 passes for 249 yards, two touchdowns and zero interceptions against the Falcons.