Patrick Mahomes put on a masterclass with three touchdown passes as the Kansas City Chiefs improved to 3-1 with a 41-31 win over Tom Brady's Tampa Bay Buccaneers on Sunday.

Mahomes moved beyond 20,000 career passing yards, completing 23 of 37 attempts for 249 yards with three TDs, including an improvised flick for the second of Clyde Edwards-Helaire's TD.

The Chiefs blew away the Bucs early, scoring touchdowns from their opening two drives of the game including a Travis Kelce touchdown after 46 seconds following a Tampa Bay turnover.

Kansas City scored four touchdowns before half-time to lead 28-17 at the main break, representing the most combined points scored in the first half of a game this season.

Running back Edwards-Helaire had 19 carries for 92 yards with one touchdown, along with his one receiving TD, while Kelce made 92 yards from nine receptions with one TD. Kelce also moved past Rob Gronkowski into fifth overall for most career receiving yards for a tight end.

L'Jarius Sneed led the Chiefs' defensive display with eight tackles, including a sack on Brady leading to Noah Grey's one-yard rushing TD. Mahomes found Jody Fortson with 5:42 remaining in the third quarter for their fifth TD to make it 38-17.

Rachaad White and Leonard Fournette scored further TDs for the Bucs to limit the margin after wide receiver Mike Evans, who had eight receptions for 103 yards, scored their two first-half touchdowns.

Brady managed three touchdown passes, throwing for 385 yards on 39-of-52 passing, but the Bucs were always playing catchup after the Chiefs' early domination. The game marked only the fifth time in Brady's career he has scored 31 points and lost.