The Kansas City Chiefs will officially begin the defence of their Super Bowl title against the Houston Texans on September 10 in the NFL's annual kickoff game – pending developments in the coronavirus pandemic.

The Chiefs rallied from a 24-0 deficit for a 51-31 victory over the Texans in the divisional round of the playoffs in January.

Tom Brady's anticipated regular-season debut with the Tampa Bay Buccaneers will come on the road against Drew Brees and the New Orleans Saints on September 13 in the first matchup of 40-plus quarterbacks in league history.

Brady's Buccaneers will appear in five primetime games, including three consecutive weeks starting October 25 with a visit to the Las Vegas Raiders at the new Allegiant Stadium as the schedule was released on Thursday. Next is a Monday night road game against the New York Giants and new coach Joe Judge followed by another matchup with Brees and the Saints on November 8, this time in Tampa Bay.

The Week 3 Monday night game features the past two league MVPs, as Lamar Jackson and the Baltimore Ravens visit Patrick Mahomes and the Chiefs.

The traditional opening weekend Monday night doubleheader has the Pittsburgh Steelers visiting the Giants and the Tennessee Titans facing the Broncos in Denver.

The Cincinnati Bengals and top overall draft pick Joe Burrow open their season at home against the Los Angeles Chargers, who used the sixth overall selection on Oregon quarterback Justin Herbert.