The San Francisco 49ers are looking to end the regular season in style as they welcome back All-Pro receiver Deebo Samuel and former starting running back Elijah Mitchell from injuries.

Arguably the hottest team in the NFL currently, the 49ers are currently riding a nine-game winning streak, and have done so in spite of some serious injuries.

Their past five wins have come with seventh-round rookie Brock Purdy playing quarterback after starter Jimmy Garoppolo suffered a season-ending injury, while Mitchell has also missed the past five games and Samuel was carted off in Week 14.

Sitting at 12-4 after beginning the campaign 3-4, the 49ers have already punched their ticket to the playoffs, but remain a chance to earn the NFC's top seed along with the Philadelphia Eagles (13-3), Minnesota Vikings (12-4) and the Dallas Cowboys (12-4).

They will enter their season finale against the visiting Arizona Cardinals as heavy favourites, with the road team on a six-game losing streak and without starting quarterback Kyler Murray since tearing his ACL.